Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 42, 2015, Pages 12956-12961

  Almutairi, Mashal M ^a,e   Park, Sung Ryeol ^b   Rose, Simon ^c   Hansen, Douglas A ^b   Vázquez Laslop, Nora ^a   Douthwaite, Stephen ^c   Sherman, David H ^b,d   Mankin, Alexander S ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antibiotics; Ketolides; Macrolides; Resistance; Ribosome

Indexed keywords

CETHROMYCIN; CHLORAMPHENICOL; KETOLIDE; NUCLEOTIDE; POLYKETIDE SYNTHASE; PROTEIN PIKR1; PROTEIN PIKR2; RNA 23S; RNA METHYLTRANSFERASE; SOLITHROMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; METHYLTRANSFERASE; RRNA (ADENOSINE-O-2'-)METHYLTRANSFERASE;

ANTIBIOTIC RESISTANCE; CONFERENCE PAPER; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STREPTOMYCES VENEZUELAE; GENETICS;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; KETOLIDES; METHYLTRANSFERASES; RNA, RIBOSOMAL, 23S;

EID: 84947264399     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1512090112     Document Type: Article

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