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Volumn 25, Issue 24, 2015, Pages 5792-5796
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Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition
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EISAI CO LTD
(Japan)
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Author keywords
Cognition; Metabotropic glutamate receptor 5 (mGlu5); Positive allosteric modulator (PAM); Tetrahydrobenzotriazole
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Indexed keywords
BENZENE DERIVATIVE;
METABOTROPIC RECEPTOR 5;
TRIAZOLE DERIVATIVE;
BENZOTRIAZOLE;
NEUROLEPTIC AGENT;
ALLOSTERISM;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ARTICLE;
COGNITION;
CONTROLLED STUDY;
DRUG EFFICACY;
DRUG IDENTIFICATION;
DRUG POTENCY;
DRUG SCREENING;
DRUG SELECTIVITY;
IN VITRO STUDY;
IN VIVO STUDY;
NONHUMAN;
NOVEL OBJECT RECOGNITION TEST;
RAT;
ANIMAL;
ANTAGONISTS AND INHIBITORS;
ASTROCYTE;
CHEMISTRY;
CYTOLOGY;
DISEASE MODEL;
DRUG EFFECTS;
HALF LIFE TIME;
HUMAN;
METABOLISM;
MICROSOME;
PRECLINICAL STUDY;
STRUCTURE ACTIVITY RELATION;
ALLOSTERIC REGULATION;
ANIMALS;
ANTIPSYCHOTIC AGENTS;
ASTROCYTES;
COGNITION;
DISEASE MODELS, ANIMAL;
DRUG EVALUATION, PRECLINICAL;
HALF-LIFE;
HUMANS;
MICROSOMES;
RATS;
RECEPTOR, METABOTROPIC GLUTAMATE 5;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRIAZOLES;
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EID: 84947203145
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2015.10.050 Document Type: Article |
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Times cited : (7)
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References (15)
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