A Delicate Balance When Substituting a Small Hydrophobe onto Low Molecular Weight Polyethylenimine to Improve Its Nucleic Acid Delivery Efficiency

ACS Applied Materials and Interfaces

Volumn 7, Issue 44, 2015, Pages 24822-24832

  Meneksedag Erol, Deniz ^a,b   Kc, Remant Bahadur ^b   Tang, Tian ^a,b   Uludag, Hasan ^a,b,c  

^a Faculty of Medicine and Dentistry   (Canada)

^b Faculty of Engineering   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

gene delivery; hydrophobic modification; molecular dynamics; polyethylenimine; siRNA

Indexed keywords

CYTOTOXICITY; GENE TRANSFER; GENES; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NUCLEIC ACIDS; PROPIONIC ACID;

GENE DELIVERY; HYDROPHOBIC MODIFICATION; MOLECULAR DYNAMICS SIMULATIONS; NONVIRAL GENE VECTORS; NUCLEIC ACID DELIVERIES; POLYETHYLENIMINES; SIRNA; SURFACE HYDROPHOBICITY;

HYDROPHOBICITY;

CARBON; GREEN FLUORESCENT PROTEIN; NUCLEIC ACID; POLYETHYLENEIMINE; PROPIONIC ACID; PROPIONIC ACID DERIVATIVE; SMALL INTERFERING RNA;

CHEMICAL PHENOMENA; CHEMISTRY; COMPUTER SIMULATION; GENE SILENCING; GENE TRANSFER; GENE VECTOR; HUMAN; HYDROGEN BOND; K-562 CELL LINE; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PROCEDURES; PROTEIN ENGINEERING; SURFACE PROPERTY;

CARBON; COMPUTER SIMULATION; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; K562 CELLS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR WEIGHT; NUCLEIC ACIDS; POLYETHYLENEIMINE; PROPIONATES; PROTEIN ENGINEERING; RNA, SMALL INTERFERING; SURFACE PROPERTIES;

EID: 84947093619     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b07929     Document Type: Article

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