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Volumn 34, Issue 45, 2015, Pages 5635-5647

Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment

Author keywords

[No Author keywords available]

Indexed keywords

FIBULIN; FIBULIN 3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; UNCLASSIFIED DRUG; EFEMP1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SCLEROPROTEIN; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR; TUMOR PROTEIN;

EID: 84947036280     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.13     Document Type: Article
Times cited : (41)

References (50)
  • 1
    • 80053401068 scopus 로고    scopus 로고
    • Breast cancer stem cells, cytokine networks, and the tumor microenvironment
    • Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 2011; 121: 3804-3809
    • (2011) J Clin Invest , vol.121 , pp. 3804-3809
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 2
    • 78650934214 scopus 로고    scopus 로고
    • Cytokine disbalance in common human cancers
    • Culig Z. Cytokine disbalance in common human cancers. Biochim Biophys Acta 2011; 1813: 308-314
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 308-314
    • Culig, Z.1
  • 3
    • 78349246291 scopus 로고    scopus 로고
    • Mammary gland growth factors: Roles in normal development and in cancer
    • Hynes NE, Watson CJ. Mammary gland growth factors: roles in normal development and in cancer. Cold Spring Harb Perspect Biol 2010; 2: a003186
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , pp. a003186
    • Hynes, N.E.1    Watson, C.J.2
  • 5
    • 12144258900 scopus 로고    scopus 로고
    • Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression
    • Muraoka-Cook RS, Dumont N, Arteaga CL. Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression. Clin Cancer Res 2005; 11: 937s-943s
    • (2005) Clin Cancer Res , vol.11 , pp. 937s-943s
    • Muraoka-Cook, R.S.1    Dumont, N.2    Arteaga, C.L.3
  • 7
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342: 1350-1358
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 8
    • 0026496172 scopus 로고
    • TGF beta signals through a heteromeric protein kinase receptor complex
    • Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M, et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 1992; 71: 1003-1014
    • (1992) Cell , vol.71 , pp. 1003-1014
    • Wrana, J.L.1    Attisano, L.2    Carcamo, J.3    Zentella, A.4    Doody, J.5    Laiho, M.6
  • 9
    • 0026672711 scopus 로고
    • Binding of two growth factor families to separate domains of the proteoglycan betaglycan
    • Andres JL, DeFalcis D, Noda M, Massague J. Binding of two growth factor families to separate domains of the proteoglycan betaglycan. J Biol Chem 1992; 267: 5927-5930
    • (1992) J Biol Chem , vol.267 , pp. 5927-5930
    • Andres, J.L.1    DeFalcis, D.2    Noda, M.3    Massague, J.4
  • 10
    • 0030604542 scopus 로고    scopus 로고
    • TGFbeta signaling: Receptors, transducers, and Mad proteins
    • Massague J. TGFbeta signaling: receptors, transducers, and Mad proteins. Cell 1996; 85: 947-950
    • (1996) Cell , vol.85 , pp. 947-950
    • Massague, J.1
  • 11
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-471
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 12
    • 0033956131 scopus 로고    scopus 로고
    • Signaling inputs converge on nuclear effectors in TGF-beta signaling
    • ten Dijke P, Miyazono K, Heldin CH. Signaling inputs converge on nuclear effectors in TGF-beta signaling. Trends Biochem Sci 2000; 25: 64-70
    • (2000) Trends Biochem Sci , vol.25 , pp. 64-70
    • Ten Dijke, P.1    Miyazono, K.2    Heldin, C.H.3
  • 13
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-beta responses
    • Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-beta responses. Cell 1998; 95: 737-740
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynck, R.1    Zhang, Y.2    Feng, X.H.3
  • 14
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGFbeta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGFbeta family signalling. Nature 2003; 425: 577-584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 15
    • 84865152701 scopus 로고    scopus 로고
    • The roles of TGF-beta signaling in carcinogenesis and breast cancer metastasis
    • Imamura T, Hikita A, Inoue Y. The roles of TGF-beta signaling in carcinogenesis and breast cancer metastasis. Breast Cancer 2012; 19: 118-124
    • (2012) Breast Cancer , vol.19 , pp. 118-124
    • Imamura, T.1    Hikita, A.2    Inoue, Y.3
  • 16
    • 84859443939 scopus 로고    scopus 로고
    • Transforming growth factorbeta signaling in tumor initiation, progression and therapy in breast cancer: An update
    • Zu X, Zhang Q, Cao R, Liu J, Zhong J, Wen G, et al. Transforming growth factorbeta signaling in tumor initiation, progression and therapy in breast cancer: an update. Cell Tissue Res 2012; 347: 73-84
    • (2012) Cell Tissue Res , vol.347 , pp. 73-84
    • Zu, X.1    Zhang, Q.2    Cao, R.3    Liu, J.4    Zhong, J.5    Wen, G.6
  • 17
    • 79959526395 scopus 로고    scopus 로고
    • TGF-beta signaling in breast cancer cell invasion and bone metastasis
    • Drabsch Y, ten Dijke P. TGF-beta signaling in breast cancer cell invasion and bone metastasis. J Mammary Gland Biol Neoplasia 2011; 16: 97-108
    • (2011) J Mammary Gland Biol Neoplasia , vol.16 , pp. 97-108
    • Drabsch, Y.1    Ten Dijke, P.2
  • 18
    • 70350231912 scopus 로고    scopus 로고
    • Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis
    • Bierie B, Moses HL. Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis. Cell Cycle 2009; 8: 3319-3327
    • (2009) Cell Cycle , vol.8 , pp. 3319-3327
    • Bierie, B.1    Moses, H.L.2
  • 19
    • 80755127904 scopus 로고    scopus 로고
    • The microenvironment in breast cancer progression: Biology and implications for treatment
    • Place AE, Jin Huh S, Polyak K. The microenvironment in breast cancer progression: biology and implications for treatment. Breast Cancer Res 2011; 13: 227
    • (2011) Breast Cancer Res , vol.13 , pp. 227
    • Place, A.E.1    Jin Huh, S.2    Polyak, K.3
  • 22
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene 2008; 27: 5904-5912
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 23
    • 33847770211 scopus 로고    scopus 로고
    • TGF-beta signaling in breast cancer
    • Buck MB, Knabbe C. TGF-beta signaling in breast cancer. Ann NY Acad Sci 2006; 1089: 119-126
    • (2006) Ann NY Acad Sci , vol.1089 , pp. 119-126
    • Buck, M.B.1    Knabbe, C.2
  • 24
    • 0033381357 scopus 로고    scopus 로고
    • The role for transforming growth factor-beta (TGF-beta) in human cancer
    • Gold LI. The role for transforming growth factor-beta (TGF-beta) in human cancer. Crit Rev Oncog 1999; 10: 303-360
    • (1999) Crit Rev Oncog , vol.10 , pp. 303-360
    • Gold, L.I.1
  • 25
    • 34347231588 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in breast cancer
    • Chang CF, Westbrook R, Ma J, Cao D. Transforming growth factor-beta signaling in breast cancer. Front Biosci 2007; 12: 4393-4401
    • (2007) Front Biosci , vol.12 , pp. 4393-4401
    • Chang, C.F.1    Westbrook, R.2    Ma, J.3    Cao, D.4
  • 26
    • 84883518362 scopus 로고    scopus 로고
    • Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment
    • Hanks BA, Holtzhausen A, Evans KS, Jamieson R, Gimpel P, Campbell OM, et al. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest 2013; 123: 3925-3940
    • (2013) J Clin Invest , vol.123 , pp. 3925-3940
    • Hanks, B.A.1    Holtzhausen, A.2    Evans, K.S.3    Jamieson, R.4    Gimpel, P.5    Campbell, O.M.6
  • 28
    • 84894211631 scopus 로고    scopus 로고
    • Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells
    • Lee JK, Park SR, Jung BK, Jeon YK, Lee YS, Kim MK, et al. Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS ONE 2013; 8: e84256
    • (2013) Plos One , vol.8 , pp. e84256
    • Lee, J.K.1    Park, S.R.2    Jung, B.K.3    Jeon, Y.K.4    Lee, Y.S.5    Kim, M.K.6
  • 29
    • 84876664814 scopus 로고    scopus 로고
    • Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells
    • O'Brien K, Rani S, Corcoran C, Wallace R, Hughes L, Friel AM, et al. Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells. Eur J Cancer 2013; 49: 1845-1859
    • (2013) Eur J Cancer , vol.49 , pp. 1845-1859
    • O'Brien, K.1    Rani, S.2    Corcoran, C.3    Wallace, R.4    Hughes, L.5    Friel, A.M.6
  • 30
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
    • Cho JA, Park H, Lim EH, Lee KW. Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells. Int J Oncol 2012; 40: 130-138
    • (2012) Int J Oncol , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 31
    • 84865218588 scopus 로고    scopus 로고
    • The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
    • Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, et al. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell 2012; 150: 764-779
    • (2012) Cell , vol.150 , pp. 764-779
    • Gao, H.1    Chakraborty, G.2    Lee-Lim, A.P.3    Mo, Q.4    Decker, M.5    Vonica, A.6
  • 34
    • 34249661138 scopus 로고    scopus 로고
    • A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization
    • Kobayashi N, Kostka G, Garbe JH, Keene DR, Bachinger HP, Hanisch FG, et al. A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. J Biol Chem 2007; 282: 11805-11816
    • (2007) J Biol Chem , vol.282 , pp. 11805-11816
    • Kobayashi, N.1    Kostka, G.2    Garbe, J.H.3    Keene, D.R.4    Bachinger, H.P.5    Hanisch, F.G.6
  • 35
    • 84881017202 scopus 로고    scopus 로고
    • Decrease of fibulin-3 in hepatocellular carcinoma indicates poor prognosis
    • Luo R, Zhang M, Liu L, Lu S, Zhang CZ, Yun J. Decrease of fibulin-3 in hepatocellular carcinoma indicates poor prognosis. PLoS ONE 2013; 8: e70511
    • (2013) Plos One , vol.8 , pp. e70511
    • Luo, R.1    Zhang, M.2    Liu, L.3    Lu, S.4    Zhang, C.Z.5    Yun, J.6
  • 36
    • 61449089633 scopus 로고    scopus 로고
    • Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker
    • Sadr-Nabavi A, Ramser J, Volkmann J, Naehrig J, Wiesmann F, Betz B, et al. Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. Int J Cancer 2009; 124: 1727-1735
    • (2009) Int J Cancer , vol.124 , pp. 1727-1735
    • Sadr-Nabavi, A.1    Ramser, J.2    Volkmann, J.3    Naehrig, J.4    Wiesmann, F.5    Betz, B.6
  • 37
    • 80052889950 scopus 로고    scopus 로고
    • Downregulation of fibulin-3 gene by promoter methylation in colorectal cancer predicts adverse prognosis
    • Tong JD, Jiao NL, Wang YX, Zhang YW, Han F. Downregulation of fibulin-3 gene by promoter methylation in colorectal cancer predicts adverse prognosis. Neoplasma 2011; 58: 441-448
    • (2011) Neoplasma , vol.58 , pp. 441-448
    • Tong, J.D.1    Jiao, N.L.2    Wang, Y.X.3    Zhang, Y.W.4    Han, F.5
  • 38
    • 79960320144 scopus 로고    scopus 로고
    • EFEMP1 as a novel DNA methylation marker for prostate cancer: Array-based DNA methylation and expression profiling
    • Kim YJ, Yoon HY, Kim SK, Kim YW, Kim EJ, Kim IY, et al. EFEMP1 as a novel DNA methylation marker for prostate cancer: array-based DNA methylation and expression profiling. Clin Cancer Res 2011; 17: 4523-4530
    • (2011) Clin Cancer Res , vol.17 , pp. 4523-4530
    • Kim, Y.J.1    Yoon, H.Y.2    Kim, S.K.3    Kim, Y.W.4    Kim, E.J.5    Kim, I.Y.6
  • 39
    • 72949110623 scopus 로고    scopus 로고
    • EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells
    • Camaj P, Seeliger H, Ischenko I, Krebs S, Blum H, De Toni EN, et al. EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. Biol Chem 2009; 390: 1293-1302
    • (2009) Biol Chem , vol.390 , pp. 1293-1302
    • Camaj, P.1    Seeliger, H.2    Ischenko, I.3    Krebs, S.4    Blum, H.5    De Toni, E.N.6
  • 40
    • 78349279900 scopus 로고    scopus 로고
    • Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity
    • Hwang CF, Chien CY, Huang SC, Yin YF, Huang CC, Fang FM, et al. Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity. J Pathol 2010; 222: 367-379
    • (2010) J Pathol , vol.222 , pp. 367-379
    • Hwang, C.F.1    Chien, C.Y.2    Huang, S.C.3    Yin, Y.F.4    Huang, C.C.5    Fang, F.M.6
  • 41
    • 84864839857 scopus 로고    scopus 로고
    • Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling
    • Hu B, Nandhu MS, Sim H, Agudelo-Garcia PA, Saldivar JC, Dolan CE, et al. Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer Res 2012; 72: 3873-3885
    • (2012) Cancer Res , vol.72 , pp. 3873-3885
    • Hu, B.1    Nandhu, M.S.2    Sim, H.3    Agudelo-Garcia, P.A.4    Saldivar, J.C.5    Dolan, C.E.6
  • 42
    • 84905705835 scopus 로고    scopus 로고
    • Fibulin-3 suppresses Wnt/betacatenin signaling and lung cancer invasion
    • Chen X, Meng J, Yue W, Yu J, Yang J, Yao Z, et al. Fibulin-3 suppresses Wnt/betacatenin signaling and lung cancer invasion. Carcinogenesis 2014; 35: 1707-1716
    • (2014) Carcinogenesis , vol.35 , pp. 1707-1716
    • Chen, X.1    Meng, J.2    Yue, W.3    Yu, J.4    Yang, J.5    Yao, Z.6
  • 43
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998; 67: 753-791
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 44
    • 0029944441 scopus 로고    scopus 로고
    • Signaling via hetero-oligomeric complexes of type i and type II serine/threonine kinase receptors
    • ten Dijke P, Miyazono K, Heldin CH. Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Curr Opin Cell Biol 1996; 8: 139-145
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 139-145
    • Ten Dijke, P.1    Miyazono, K.2    Heldin, C.H.3
  • 45
    • 0242285692 scopus 로고    scopus 로고
    • TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
    • Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR, et al. TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest 2003; 112: 1116-1124
    • (2003) J Clin Invest , vol.112 , pp. 1116-1124
    • Tang, B.1    Vu, M.2    Booker, T.3    Santner, S.J.4    Miller, F.R.5    Anver, M.R.6
  • 47
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential diss.E.M.Ination of subpopulations of a mouse mammary tumor
    • Aslakson CJ, Miller FR. Selective events in the metastatic process defined by analysis of the sequential diss.e.m.ination of subpopulations of a mouse mammary tumor. Cancer Res 1992; 52: 1399-1405
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 48
    • 84862920643 scopus 로고    scopus 로고
    • Fibulin-3 promoter methylation alters the invasive behavior of non-small cell lung cancer cell lines via MMP-7 and MMP-2 regulation
    • Kim EJ, Lee SY, Woo MK, Choi SI, Kim TR, Kim MJ, et al. Fibulin-3 promoter methylation alters the invasive behavior of non-small cell lung cancer cell lines via MMP-7 and MMP-2 regulation. Int J Oncol 2012; 40: 402-408
    • (2012) Int J Oncol , vol.40 , pp. 402-408
    • Kim, E.J.1    Lee, S.Y.2    Woo, M.K.3    Choi, S.I.4    Kim, T.R.5    Kim, M.J.6
  • 49
    • 84861171721 scopus 로고    scopus 로고
    • CDH13 and FLBN3 gene methylation are associated with poor prognosis in colorectal cancer
    • Wang Z, Yuan X, Jiao N, Zhu H, Zhang Y, Tong J. CDH13 and FLBN3 gene methylation are associated with poor prognosis in colorectal cancer. Pathol Oncol Res 2012; 18: 263-270
    • (2012) Pathol Oncol Res , vol.18 , pp. 263-270
    • Wang, Z.1    Yuan, X.2    Jiao, N.3    Zhu, H.4    Zhang, Y.5    Tong, J.6


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