Control of excitatory and inhibitory synapse formation by neuroligins

Science

Volumn 307, Issue 5713, 2005, Pages 1324-1328

  Chih, Ben ^a   Engelman, Holly ^a   Scheiffele, Peter ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; RNA;

BIDIRECTIONAL SIGNALING; EXCITATORY SYNAPTIC INPUTS; INHIBITORY SYNAPTIC INPUTS;

NEUROLOGY;

CELL ADHESION MOLECULE; GLUTAMATE RECEPTOR; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLIGIN; RECEPTOR SUBUNIT; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

BIOLOGY;

ANIMAL CELL; ARTICLE; AUTISM; GENE MUTATION; HIPPOCAMPUS; NERVE CELL; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SYNAPSE;

ACTION POTENTIALS; ANIMALS; CELL LINE; CELLS, CULTURED; DENDRITES; DOWN-REGULATION; EVOKED POTENTIALS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MUTATION; NERVE TISSUE PROTEINS; NEURAL INHIBITION; NEURONS; PRESYNAPTIC TERMINALS; PROTEIN ISOFORMS; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; RNA INTERFERENCE; SYNAPSES; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION; TRANSFECTION; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1; VESICULAR INHIBITORY AMINO ACID TRANSPORT PROTEINS;

EID: 13544269142     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1107470     Document Type: Article

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29. We thank T. Jessell and A. Eickhorst for comments on the manuscript, L. van Parijs for vector DNA, A. MacDermott and G. Crabtree for generously sharing equipment, C. Torsney for help with statistical analysis, M. Peck for help with quantifications, and J. Dodd for continuous support. This work was financially supported by the Irma T. Hirschl Fund, the Searle Scholar Program, the John Merck Fund, and National Institute of Neurological Disorders and Stroke.