Truncated amyloid-β(11-40/42) from Alzheimer disease binds Cu2+ with a femtomolar affinity and influences fiber assembly

Journal of Biological Chemistry

Volumn 290, Issue 46, 2015, Pages 27791-27802

  Barritt, Joseph D ^a   Viles, John H ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CEREBROSPINAL FLUID; DISSOCIATION; FIBERS; GLYCOPROTEINS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; NEURODEGENERATIVE DISEASES; TRANSMISSION ELECTRON MICROSCOPY;

ALZHEIMER DISEASE; DISSOCIATION CONSTANT; FIBER ASSEMBLIES; N-TERMINAL SEQUENCES; NATURALLY OCCURRING; ORDERS OF MAGNITUDE; SPECTROSCOPIC TECHNIQUE; TRANSPORT PROTEINS;

COPPER COMPOUNDS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[11-40]; AMYLOID BETA PROTEIN[11-42]; COPPER ION; HUMAN SERUM ALBUMIN; UNCLASSIFIED DRUG; AMYLOID BETA-PROTEIN (11-40); AMYLOID BETA-PROTEIN (11-42); COPPER; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; AMYLOID PLAQUE; AMYLOIDOSIS; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); DISSOCIATION CONSTANT; ELECTRON SPIN RESONANCE; PH; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; TRANSMISSION ELECTRON MICROSCOPY; CHEMISTRY; HUMAN; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; COPPER; HUMANS; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID;

EID: 84946944108     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.684084     Document Type: Article

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