Streptococcus pneumoniae NanC: Structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor

Journal of Biological Chemistry

Volumn 290, Issue 46, 2015, Pages 27736-27748

  Owen, C David ^a   Lukacik, Petra ^b,c   Potter, Jane A ^a   Sleator, Olivia ^d,e   Taylor, Garry L ^a   Walsh, Martin A ^b,d  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^c Research Complex at Harwell   (United Kingdom)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^e Rigaku Europe   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINS; CARBON; LIGANDS; SCAFFOLDS;

3-DIDEHYDRO-N-ACETYLNEURAMINIC ACID; CARBOHYDRATE BINDING MODULES; CONFORMATION CHANGE; MECHANISTIC DIVERSITY; N-ACETYLNEURAMINIC ACID; SIALIDASE INHIBITORS; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL INSIGHTS;

CRYSTAL STRUCTURE;

2 DEOXY 2,3 DIDEHYDRO N ACETYLNEURAMINIC ACID; 3 FLUORO BETA N ACETYLNEURAMINIC ACID; ASPARTIC ACID; N CETYLNEURAMINIC ACID; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; 5-ACETAMIDO-2,6-ANHYDRO-2,3-DEHYDRO-3,5-DIDEOXY-GLYCEROGALACTONONANOIC ACID; BACTERIAL PROTEIN; ENZYME INHIBITOR; SUGAR ACID;

ARTICLE; CATALYST; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PNEUMONIAE NANC; CHEMISTRY; ENZYMOLOGY; SYNTHESIS; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; NEURAMINIDASE; STREPTOCOCCUS PNEUMONIAE; SUGAR ACIDS;

EID: 84946944104     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.673632     Document Type: Article

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