Intraoperative protective mechanical ventilation for prevention of postoperative pulmonary complications: A comprehensive review of the role of tidal volume, positive end-expiratory pressure, and lung recruitment maneuvers

Anesthesiology

Volumn 123, Issue 3, 2015, Pages 692-713

  Güldner, Andreas ^a   Kiss, Thomas ^a   Serpa Neto, Ary ^b   Hemmes, Sabrine N T ^c   Canet, Jaume ^d   Spieth, Peter M ^a   Rocco, Patricia R M ^e   Schultz, Marcus J ^c   Pelosi, Paolo ^f   Gama De Abreu, Marcelo ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^e FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^f UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL VENTILATION; ATELECTASIS; HUMAN; INTRAOPERATIVE PERIOD; LUNG COMPLICATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; TIDAL VOLUME; VENTILATOR; VENTILATOR INDUCED LUNG INJURY; ADVERSE EFFECTS; ANIMAL; LUNG; PEROPERATIVE CARE; PHYSIOLOGY; POSTOPERATIVE COMPLICATIONS; PROCEDURES; VENTILATOR-INDUCED LUNG INJURY;

ANIMALS; HUMANS; INTRAOPERATIVE CARE; LUNG; POSITIVE-PRESSURE RESPIRATION; POSTOPERATIVE COMPLICATIONS; RESPIRATION, ARTIFICIAL; TIDAL VOLUME; VENTILATOR-INDUCED LUNG INJURY;

EID: 84946921931     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000754     Document Type: Review

References (131)

1. Canet J, Gallart L, Gomar C, Paluzie G, Vallès J, Castillo J, Sabaté S, Mazo V, Briones Z, Sanchis J; ARISCAT Group: Prediction of postoperative pulmonary complications in a population-based surgical cohort. ANESTHESIOLOGY 2010;113:1338-50
2. Mazo V, Sabaté S, Canet J, Gallart L, Gama de Abreu M, Belda J, Langeron O, Hoeft A, Pelosi P: Prospective external validation of a predictive score for postoperative pulmonary complications. ANESTHESIOLOGY 2014; 121:219-31
3. Fernández-Pérez ER, Sprung J, Afessa B, Warner DO, Vachon CM, Schroeder DR, Brown DR, Hubmayr RD, Gajic O: Intraoperative ventilator settings and acute lung injury after elective surgery: A nested case control study. Thorax 2009; 64:121-7
4. Hemmes SN, Serpa Neto A, Schultz MJ: Intraoperative ventilatory strategies to prevent postoperative pulmonary complications: A meta-analysis. Curr Opin Anaesthesiol 2013; 26:126-33
5. Futier E, Constantin JM, Jaber S: Protective lung ventilation in operating room: A systematic review. Minerva Anestesiol 2014; 80:726-35
6. Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H III, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman DA, Esper AM, Sadikot R, Douglas I, Sevransky J, Malinchoc M; U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS): Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med 2011; 183:462-70
7. Canet J, Gallart L: Predicting postoperative pulmonary complications in the general population. Curr Opin Anaesthesiol 2013; 26:107-15
8. Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A, Hoeft A, Walder B, Chew MS, Pearse RM; European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM): Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: A statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol 2015; 32:88-105
9. Arozullah AM, Daley J, Henderson WG, Khuri SF: Multifactorial risk index for predicting postoperative respiratory failure in men after major noncardiac surgery. The National Veterans Administration Surgical Quality Improvement Program. Ann Surg 2000; 232:242-53
10. Arozullah AM, Khuri SF, Henderson WG, Daley J; Participants in the National Veterans Affairs Surgical Quality Improvement Program: Development and validation of a multifactorial risk index for predicting postoperative pneumonia after major noncardiac surgery. Ann Intern Med 2001; 135:847-57
11. Canet J, Gallart L: Postoperative respiratory failure: Pathogenesis, prediction, and prevention. Curr Opin Crit Care 2014; 20:56-62
12. Sabaté S, Mazo V, Canet J: Predicting postoperative pulmonary complications: Implications for outcomes and costs. Curr Opin Anaesthesiol 2014; 27:201-9
13. Smetana GW, Lawrence VA, Cornell JE; American College of Physicians: Preoperative pulmonary risk stratification for non-cardiothoracic surgery: Systematic review for the American College of Physicians. Ann Intern Med 2006; 144:581-95
14. Johnson RG, Arozullah AM, Neumayer L, Henderson WG, Hosokawa P, Khuri SF: Multivariable predictors of postoperative respiratory failure after general and vascular surgery: Results from the patient safety in surgery study. J Am Coll Surg 2007; 204:1188-98
15. Brueckmann B, Villa-Uribe JL, Bateman BT, Grosse-Sundrup M, Hess DR, Schlett CL, Eikermann M: Development and validation of a score for prediction of postoperative respiratory complications. ANESTHESIOLOGY 2013; 118:1276-85
16. Kor DJ, Lingineni RK, Gajic O, Park PK, Blum JM, Hou PC, Hoth JJ, Anderson HL III, Bajwa EK, Bartz RR, Adesanya A, Festic E, Gong MN, Carter RE, Talmor DS: Predicting risk of postoperative lung injury in high-risk surgical patients: A multicenter cohort study. ANESTHESIOLOGY 2014; 120:1168-81
17. Trillo-Alvarez C, Cartin-Ceba R, Kor DJ, Kojicic M, Kashyap R, Thakur S, Thakur L, Herasevich V, Malinchoc M, Gajic O: Acute lung injury prediction score: Derivation and validation in a population-based sample. Eur Respir J 2011; 37:604-9
18. Kor DJ, Warner DO, Alsara A, Fernández-Pérez ER, Malinchoc M, Kashyap R, Li G, Gajic O: Derivation and diagnostic accuracy of the surgical lung injury prediction model. ANESTHESIOLOGY 2011; 115:117-28
19. Higuita-Castro N, Mihai C, Hansford DJ, Ghadiali SN: Influence of airway wall compliance on epithelial cell injury and adhesion during interfacial flows. J Appl Physiol (1985) 2014; 117:1231-42
20. Mead J, Takishima T, Leith D: Stress distribution in lungs: A model of pulmonary elasticity. J Appl Physiol 1970;28:596-608
21. Needham DM, Colantuoni E, Mendez-Tellez PA, Dinglas VD, Sevransky JE, Dennison Himmelfarb CR, Desai SV, Shanholtz C, Brower RG, Pronovost PJ: Lung protective mechanical ventilation and two year survival in patients with acute lung injury: Prospective cohort study. BMJ 2012; 344:e2124
22. Hager DN, Krishnan JA, Hayden DL, Brower RG; ARDS Clinical Trials Network: Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am J Respir Crit Care Med 2005; 172:1241-5
23. Tremblay LN, Slutsky AS: Ventilator-induced lung injury: From the bench to the bedside. Intensive Care Med 2006; 32:24-33
24. Chiumello D, Carlesso E, Cadringher P, Caironi P, Valenza F, Polli F, Tallarini F, Cozzi P, Cressoni M, Colombo A, Marini JJ, Gattinoni L: Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med 2008; 178:346-55
25. Protti A, Cressoni M, Santini A, Langer T, Mietto C, Febres D, Chierichetti M, Coppola S, Conte G, Gatti S, Leopardi O, Masson S, Lombardi L, Lazzerini M, Rampoldi E, Cadringher P, Gattinoni L: Lung stress and strain during mechanical ventilation: Any safe threshold? Am J Respir Crit Care Med 2011; 183:1354-62
26. Spieth PM, Silva PL, Garcia CS, Ornellas DS, Samary CS, Moraes L, Bentes M, Morales MM, Kasper M, Güldner A, Huhle R, Koch T, Pelosi P, de Abreu MG, Rocco PR: Modulation of stress versus time product during mechanical ventilation influences inflammation as well as alveolar epithelial and endothelial response in rats. ANESTHESIOLOGY 2015; 122:106-16
27. Davidovich N, DiPaolo BC, Lawrence GG, Chhour P, Yehya N, Margulies SS: Cyclic stretch-induced oxidative stress increases pulmonary alveolar epithelial permeability. Am J Respir Cell Mol Biol 2013; 49:156-64
28. Hussein O, Walters B, Stroetz R, Valencia P, McCall D, Hubmayr RD: Biophysical determinants of alveolar epithelial plasma membrane wounding associated with mechanical ventilation. Am J Physiol Lung Cell Mol Physiol 2013; 305:L478-84
29. Suki B, Hubmayr R: Epithelial and endothelial damage induced by mechanical ventilation modes. Curr Opin Crit Care 2014; 20:17-24
30. Moriondo A, Pelosi P, Passi A, Viola M, Marcozzi C, Severgnini P, Ottani V, Quaranta M, Negrini D: Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats. J Appl Physiol (1985) 2007; 103:747-56
31. Moriondo A, Marcozzi C, Bianchin F, Passi A, Boschetti F, Lattanzio S, Severgnini P, Pelosi P, Negrini D: Impact of respiratory pattern on lung mechanics and interstitial proteoglycans in spontaneously breathing anaesthetized healthy rats. Acta Physiol (Oxf) 2011; 203:331-41
32. Pelosi P, Rocco PR: Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med 2008; 34:631-9
33. Negrini D, Passi A, Moriondo A: The role of proteoglycans in pulmonary edema development. Intensive Care Med 2008; 34:610-8
34. Moriondo A, Marcozzi C, Bianchin F, Reguzzoni M, Severgnini P, Protasoni M, Raspanti M, Passi A, Pelosi P, Negrini D: Impact of mechanical ventilation and fluid load on pulmonary glycosaminoglycans. Respir Physiol Neurobiol 2012; 181:308-20
35. Spieth PM, Bluth T, Gama De Abreu M, Bacelis A, Goetz AE, Kiefmann R: Mechanotransduction in the lungs. Minerva Anestesiol 2014; 80:933-41
36. Rocco PR, Dos Santos C, Pelosi P: Pathophysiology of ventilator-associated lung injury. Curr Opin Anaesthesiol 2012; 25:123-30
37. Uhlig S: Ventilation-induced lung injury and mechanotransduction: Stretching it too far? Am J Physiol Lung Cell Mol Physiol 2002; 282:L892-6
38. Parker JC, Hernandez LA, Longenecker GL, Peevy K, Johnson W: Lung edema caused by high peak inspiratory pressures in dogs. Role of increased microvascular filtration pressure and permeability. Am Rev Respir Dis 1990; 142:321-8
39. West JB, Tsukimoto K, Mathieu-Costello O, Prediletto R: Stress failure in pulmonary capillaries. J Appl Physiol (1985) 1991; 70:1731-42
40. Tinsley JH, De Lanerolle P, Wilson E, Ma W, Yuan SY: Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability. Am J Physiol Cell Physiol 2000; 279:C1285-9
41. Del Maschio A, Zanetti A, Corada M, Rival Y, Ruco L, Lampugnani MG, Dejana E: Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. J Cell Biol 1996; 135:497-510
42. Cavanaugh KJ Jr, Oswari J, Margulies SS: Role of stretch on tight junction structure in alveolar epithelial cells. Am J Respir Cell Mol Biol 2001; 25:584-91
43. Egan EA: Lung inflation, lung solute permeability, and alveolar edema. J Appl Physiol Respir Environ Exerc Physiol 1982; 53:121-5
44. Albert RK, Lakshminarayan S, Hildebrandt J, Kirk W, Butler J: Increased surface tension favors pulmonary edema formation in anesthetized dogs' lungs. J Clin Invest 1979; 63:1015-8
45. Pecchiari M, Monaco A, Koutsoukou A, D'Angelo E: Plasma membrane disruptions with different modes of injurious mechanical ventilation in normal rat lungs. Crit Care Med 2012; 40:869-75
46. D'Angelo E, Koutsoukou A, Della Valle P, Gentile G, Pecchiari M: Cytokine release, small airway injury, and parenchymal damage during mechanical ventilation in normal open-chest rats. J Appl Physiol (1985) 2008; 104:41-9
47. Lecuona E, Saldías F, Comellas A, Ridge K, Guerrero C, Sznajder JI: Ventilator-associated lung injury decreases lung ability to clear edema in rats. Am J Respir Crit Care Med 1999; 159:603-9
48. Planès C, Escoubet B, Blot-Chabaud M, Friedlander G, Farman N, Clerici C: Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am J Respir Cell Mol Biol 1997; 17:508-18
49. Bhattacharya J, Matthay MA: Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol 2013; 75:593-615
50. Rugonyi S, Biswas SC, Hall SB: The biophysical function of pulmonary surfactant. Respir Physiol Neurobiol 2008; 163:244-55
51. Vlahakis NE, Hubmayr RD: Cellular stress failure in ventilator-injured lungs. Am J Respir Crit Care Med 2005; 171:1328-42
52. Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS: Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 2003; 289:2104-12
53. Rothen HU, Sporre B, Engberg G, Wegenius G, Högman M, Hedenstierna G: Influence of gas composition on recurrence of atelectasis after a reexpansion maneuver during general anesthesia. ANESTHESIOLOGY 1995; 82:832-42
54. Joyce CJ, Williams AB: Kinetics of absorption atelectasis during anesthesia: A mathematical model. J Appl Physiol (1985) 1999; 86:1116-25
55. D'Angelo E: Factors affecting the distribution of transpulmonary pressure in animals and in man. Bull Eur Physiopathol Respir 1984; 20:415-22
56. Pelosi P, Ravagnan I, Giurati G, Panigada M, Bottino N, Tredici S, Eccher G, Gattinoni L: Positive end-expiratory pressure improves respiratory function in obese but not in normal subjects during anesthesia and paralysis. ANESTHESIOLOGY 1999; 91:1221-31
57. Albert RK, Hubmayr RD: The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med 2000; 161:1660-5
58. Pelosi P, Goldner M, McKibben A, Adams A, Eccher G, Caironi P, Losappio S, Gattinoni L, Marini JJ: Recruitment and derecruitment during acute respiratory failure: An experimental study. Am J Respir Crit Care Med 2001; 164:122-30
59. van Kaam AH, Lachmann RA, Herting E, De Jaegere A, van Iwaarden F, Noorduyn LA, Kok JH, Haitsma JJ, Lachmann B: Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia. Am J Respir Crit Care Med 2004; 169:1046-53
60. Lachmann RA, van Kaam AH, Haitsma JJ, Lachmann B: High positive end-expiratory pressure levels promote bacterial translocation in experimental pneumonia. Intensive Care Med 2007; 33:1800-4
61. Fanelli V, Mascia L, Puntorieri V, Assenzio B, Elia V, Fornaro G, Martin EL, Bosco M, Delsedime L, Fiore T, Grasso S, Ranieri VM: Pulmonary atelectasis during low stretch ventilation: "Open lung" versus "lung rest" strategy. Crit Care Med 2009; 37:1046-53
62. Vaneker M, Halbertsma FJ, van Egmond J, Netea MG, Dijkman HB, Snijdelaar DG, Joosten LA, van der Hoeven JG, Scheffer GJ: Mechanical ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: An in vivo model using clinical relevant ventilation settings. ANESTHESIOLOGY 2007; 107:419-26
63. Wolthuis EK, Vlaar AP, Choi G, Roelofs JJ, Juffermans NP, Schultz MJ: Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of preexisting lung injury in healthy mice. Crit Care 2009; 13:R1
64. Hegeman MA, Hemmes SN, Kuipers MT, Bos LD, Jongsma G, Roelofs JJ, van der Sluijs KF, Juffermans NP, Vroom MB, Schultz MJ: The extent of ventilator-induced lung injury in mice partly depends on duration of mechanical ventilation. Crit Care Res Pract 2013; 2013:435236
65. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Zheng H, Venegas JG, Vidal Melo MF: Effect of local tidal lung strain on inflammation in normal and lipopolysaccharide-exposed sheep. Crit Care Med 2014; 42:e491-500
66. Lundquist H, Hedenstierna G, Strandberg A, Tokics L, Brismar B: CT-assessment of dependent lung densities in man during general anaesthesia. Acta Radiol 1995; 36:626-32
67. Cai H, Gong H, Zhang L, Wang Y, Tian Y: Effect of low tidal volume ventilation on atelectasis in patients during general anesthesia: A computed tomographic scan. J Clin Anesth 2007; 19:125-9
68. Rusca M, Proietti S, Schnyder P, Frascarolo P, Hedenstierna G, Spahn DR, Magnusson L: Prevention of atelectasis formation during induction of general anesthesia. Anesth Analg 2003; 97:1835-9
69. Neumann P, Rothen HU, Berglund JE, Valtysson J, Magnusson A, Hedenstierna G: Positive end-expiratory pressure prevents atelectasis during general anaesthesia even in the presence of a high inspired oxygen concentration. Acta Anaesthesiol Scand 1999; 43:295-301
70. Milic-Emili J, Torchio R, D'Angelo E: Closing volume: A reappraisal (1967-2007). Eur J Appl Physiol 2007; 99:567-83
71. Juno J, Marsh HM, Knopp TJ, Rehder K: Closing capacity in awake and anesthetized-paralyzed man. J Appl Physiol Respir Environ Exerc Physiol 1978; 44:238-44
72. Bergman NA, Tien YK: Contribution of the closure of pulmonary units to impaired oxygenation during anesthesia. ANESTHESIOLOGY 1983; 59:395-401
73. Stanley TH, Zikria BA, Sullivan SF: The surface tension of tracheobronchial secretions during general anesthesia. ANESTHESIOLOGY 1972; 37:445-9
74. Bendixen HH, Hedley-Whyte J, Laver MB: Impaired oxygenation in surgical patients during general anesthesia with controlled ventilation. A concept of atelectasis. N Engl J Med 1963; 269:991-6
75. Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Peñuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguía C, Violi DA, Thille AW, Brochard L, González M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Pelosi P, Soto L, Tomicic V, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bülow HH, Zeggwagh AA, Anzueto A: Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 2013; 188:220-30
76. Hess DR, Kondili D, Burns E, Bittner EA, Schmidt UH: A 5-year observational study of lung-protective ventilation in the operating room: A single-center experience. J Crit Care 2013; 28:533.e9-15
77. Levin MA, McCormick PJ, Lin HM, Hosseinian L, Fischer GW: Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality. Br J Anaesth 2014; 113:97-108
78. Hong CM, Xu DZ, Lu Q, Cheng Y, Pisarenko V, Doucet D, Brown M, Aisner S, Zhang C, Deitch EA, Delphin E: Low tidal volume and high positive end-expiratory pressure mechanical ventilation results in increased inflammation and ventilator-associated lung injury in normal lungs. Anesth Analg 2010; 110:1652-60
79. Wrigge H, Zinserling J, Stüber F, von Spiegel T, Hering R, Wetegrove S, Hoeft A, Putensen C: Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function. ANESTHESIOLOGY 2000; 93:1413-7
80. Wrigge H, Uhlig U, Zinserling J, Behrends-Callsen E, Ottersbach G, Fischer M, Uhlig S, Putensen C: The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery. Anesth Analg 2004; 98:775-81
81. Wrigge H, Uhlig U, Baumgarten G, Menzenbach J, Zinserling J, Ernst M, Drömann D, Welz A, Uhlig S, Putensen C: Mechanical ventilation strategies and inflammatory responses to cardiac surgery: A prospective randomized clinical trial. Intensive Care Med 2005; 31:1379-87
82. Gama de Abreu M, Heintz M, Heller AR, Sezchenyi RCM, Albrecht DM, Koch T: One-lung ventilation with high tidal volumes and zero positive end-expiratory pressure is injurious in the isolated rabbit lung model. Anesth Analg 2003; 96:220-8
83. Kozian A, Schilling T, Schütze H, Senturk M, Hachenberg T, Hedenstierna G: Ventilatory protective strategies during thoracic surgery: Effects of alveolar recruitment maneuver and low-tidal volume ventilation on lung density distribution. ANESTHESIOLOGY 2011; 114:1025-35
84. Schilling T, Kozian A, Huth C, Bühling F, Kretzschmar M, Welte T, Hachenberg T: The pulmonary immune effects of mechanical ventilation in patients undergoing thoracic surgery. Anesth Analg 2005; 101:957-65
85. Michelet P, D'Journo XB, Roch A, Doddoli C, Marin V, Papazian L, Decamps I, Bregeon F, Thomas P, Auffray JP: Protective ventilation influences systemic inflammation after esophagectomy: A randomized controlled study. ANESTHESIOLOGY 2006; 105:911-9
86. Licker M, Diaper J, Villiger Y, Spiliopoulos A, Licker V, Robert J, Tschopp JM: Impact of intraoperative lung-protective interventions in patients undergoing lung cancer surgery. Crit Care 2009; 13:R41
87. Shen Y, Zhong M, Wu W, Wang H, Feng M, Tan L, Wang Q: The impact of tidal volume on pulmonary complications following minimally invasive esophagectomy: A randomized and controlled study. J Thorac Cardiovasc Surg 2013; 146:1267-73; discussion 1273-4
88. Hemmes SN, Gama de Abreu M, Pelosi P, Schultz MJ: High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): A multicentre randomised controlled trial. Lancet 2014; 384:495-503
89. Scott DH, Drummond GB: III. Tidal volume measurement: OK for science, but too difficult for a workstation standard? Br J Anaesth 2013; 110:891-5
90. Brismar B, Hedenstierna G, Lundquist H, Strandberg A, Svensson L, Tokics L: Pulmonary densities during anesthesia with muscular relaxation - A proposal of atelectasis. ANESTHESIOLOGY 1985; 62:422-8
91. Reinius H, Jonsson L, Gustafsson S, Sundbom M, Duvernoy O, Pelosi P, Hedenstierna G, Fredén F: Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: A computerized tomography study. ANESTHESIOLOGY 2009; 111:979-87
92. Maisch S, Reissmann H, Fuellekrug B, Weismann D, Rutkowski T, Tusman G, Bohm SH: Compliance and dead space fraction indicate an optimal level of positive end-expiratory pressure after recruitment in anesthetized patients. Anesth Analg 2008; 106:175-81
93. Satoh D, Kurosawa S, Kirino W, Wagatsuma T, Ejima Y, Yoshida A, Toyama H, Nagaya K: Impact of changes of positive end-expiratory pressure on functional residual capacity at low tidal volume ventilation during general anesthesia. J Anesth 2012; 26:664-9
94. Futier E, Constantin JM, Petit A, Jung B, Kwiatkowski F, Duclos M, Jaber S, Bazin JE: Positive end-expiratory pressure improves end-expiratory lung volume but not oxygenation after induction of anaesthesia. Eur J Anaesthesiol 2010; 27:508-13
95. Reis Miranda D, Gommers D, Struijs A, Dekker R, Mekel J, Feelders R, Lachmann B, Bogers AJ: Ventilation according to the open lung concept attenuates pulmonary inflammatory response in cardiac surgery. Eur J Cardiothorac Surg 2005; 28:889-95
96. Cinnella G, Grasso S, Spadaro S, Rauseo M, Mirabella L, Salatto P, De Capraris A, Nappi L, Greco P, Dambrosio M: Effects of recruitment maneuver and positive end-expiratory pressure on respiratory mechanics and transpulmonary pressure during laparoscopic surgery. ANESTHESIOLOGY 2013; 118:114-22
97. Karsten J, Luepschen H, Grossherr M, Bruch HP, Leonhardt S, Gehring H, Meier T: Effect of PEEP on regional ventilation during laparoscopic surgery monitored by electrical impedance tomography. Acta Anaesthesiol Scand 2011; 55:878-86
98. Zhao Z, Guttmann J, Möller K: Adaptive SLICE method: An enhanced method to determine nonlinear dynamic respiratory system mechanics. Physiol Meas 2012; 33:51-64
99. Gattinoni L, Carlesso E, Caironi P: Stress and strain within the lung. Curr Opin Crit Care 2012; 18:42-7
100. Weingarten TN, Whalen FX, Warner DO, Gajic O, Schears GJ, Snyder MR, Schroeder DR, Sprung J: Comparison of two ventilatory strategies in elderly patients undergoing major abdominal surgery. Br J Anaesth 2010; 104:16-22
101. Wetterslev J, Hansen EG, Roikjaer O, Kanstrup IL, Heslet L: Optimizing peroperative compliance with PEEP during upper abdominal surgery: Effects on perioperative oxygenation and complications in patients without preoperative cardiopulmonary dysfunction. Eur J Anaesthesiol 2001; 18:358-65
102. Rothen HU, Neumann P, Berglund JE, Valtysson J, Magnusson A, Hedenstierna G: Dynamics of re-expansion of atelectasis during general anaesthesia. Br J Anaesth 1999; 82:551-6
103. Tusman G, Groisman I, Fiolo FE, Scandurra A, Arca JM, Krumrick G, Bohm SH, Sipmann FS: Noninvasive monitoring of lung recruitment maneuvers in morbidly obese patients: The role of pulse oximetry and volumetric capnography. Anesth Analg 2014; 118:137-44
104. Rothen HU, Sporre B, Engberg G, Wegenius G, Hedenstierna G: Re-expansion of atelectasis during general anaesthesia: A computed tomography study. Br J Anaesth 1993; 71:788-95
105. Lin WQ, Lu XY, Cao LH, Wen LL, Bai XH, Zhong ZJ: [Effects of the lung protective ventilatory strategy on proinflammatory cytokine release during one-lung ventilation]. Ai Zheng 2008; 27:870-3
106. Unzueta C, Tusman G, Suarez-Sipmann F, Böhm S, Moral V: Alveolar recruitment improves ventilation during thoracic surgery: A randomized controlled trial. Br J Anaesth 2012; 108:517-24
107. Koner O, Celebi S, Balci H, Cetin G, Karaoglu K, Cakar N: Effects of protective and conventional mechanical ventilation on pulmonary function and systemic cytokine release after cardiopulmonary bypass. Intensive Care Med 2004; 30:620-6
108. Zupancich E, Paparella D, Turani F, Munch C, Rossi A, Massaccesi S, Ranieri VM: Mechanical ventilation affects inflammatory mediators in patients undergoing cardiopulmonary bypass for cardiac surgery: A randomized clinical trial. J Thorac Cardiovasc Surg 2005; 130:378-83
109. Wolthuis EK, Choi G, Dessing MC, Bresser P, Lutter R, Dzoljic M, van der Poll T, Vroom MB, Hollmann M, Schultz MJ: Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. ANESTHESIOLOGY 2008; 108:46-54
110. Memtsoudis SG, Bombardieri AM, Ma Y, Girardi FP: The effect of low versus high tidal volume ventilation on inflammatory markers in healthy individuals undergoing posterior spine fusion in the prone position: A randomized controlled trial. J Clin Anesth 2012; 24:263-9
111. Treschan TA, Kaisers W, Schaefer MS, Bastin B, Schmalz U, Wania V, Eisenberger CF, Saleh A, Weiss M, Schmitz A, Kienbaum P, Sessler DI, Pannen B, Beiderlinden M: Ventilation with low tidal volumes during upper abdominal surgery does not improve postoperative lung function. Br J Anaesth 2012; 109:263-71
112. Futier E, Constantin JM, Paugam-Burtz C, Pascal J, Eurin M, Neuschwander A, Marret E, Beaussier M, Gutton C, Lefrant JY, Allaouchiche B, Verzilli D, Leone M, De Jong A, Bazin JE, Pereira B, Jaber S; IMPROVE Study Group: A trial of intraoperative low-tidal-volume ventilation in abdominal surgery. N Engl J Med 2013; 369:428-37
113. Severgnini P, Selmo G, Lanza C, Chiesa A, Frigerio A, Bacuzzi A, Dionigi G, Novario R, Gregoretti C, Gama de Abreu M, Schultz MJ, Jaber S, Futier E, Chiaranda M, Pelosi P: Protective mechanical ventilation during general anesthesia for open abdominal surgery improves postoperative pulmonary function. ANESTHESIOLOGY 2013; 118:1307-21
114. Maslow AD, Stafford TS, Davignon KR, Ng T: A randomized comparison of different ventilator strategies during thoracotomy for pulmonary resection. J Thorac Cardiovasc Surg 2013; 146:38-44
115. Sundar S, Novack V, Jervis K, Bender SP, Lerner A, Panzica P, Mahmood F, Malhotra A, Talmor D: Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients. ANESTHESIOLOGY 2011; 114:1102-10
116. Ge Y, Yuan L, Jiang X, Wang X, Xu R, Ma W: [Effect of lung protection mechanical ventilation on respiratory function in the elderly undergoing spinal fusion]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013; 38:81-5
117. Bouadma L, Dreyfuss D, Ricard JD, Martet G, Saumon G: Mechanical ventilation and hemorrhagic shock-resuscitation interact to increase inflammatory cytokine release in rats. Crit Care Med 2007; 35:2601-6
118. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P: Meta-analysis: Ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med 2009; 151:566-76
119. Serpa Neto A, Cardoso SO, Manetta JA, Pereira VG, Espósito DC, Pasqualucci Mde O, Damasceno MC, Schultz MJ: Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: A meta-analysis. JAMA 2012; 308:1651-9
120. Lellouche F, Dionne S, Simard S, Bussières J, Dagenais F: High tidal volumes in mechanically ventilated patients increase organ dysfunction after cardiac surgery. ANESTHESIOLOGY 2012; 116:1072-82
121. Jaber S, Coisel Y, Chanques G, Futier E, Constantin JM, Michelet P, Beaussier M, Lefrant JY, Allaouchiche B, Capdevila X, Marret E: A multicentre observational study of intra-operative ventilatory management during general anaesthesia: Tidal volumes and relation to body weight. Anaesthesia 2012; 67:999-1008
122. Chaiwat O, Vavilala MS, Philip S, Malakouti A, Neff MJ, Deem S, Treggiari MM, Wang J, Lang JD: Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury. J Crit Care 2011; 26:144-51
123. Goldenberg NM, Steinberg BE, Lee WL, Wijeysundera DN, Kavanagh BP: Lung-protective ventilation in the operating room: Time to implement? ANESTHESIOLOGY 2014; 121:184-8
124. Futier E, Marret E, Jaber S: Perioperative positive pressure ventilation: An integrated approach to improve pulmonary care. ANESTHESIOLOGY 2014; 121:400-8
125. Coppola S, Froio S, Chiumello D: Protective lung ventilation during general anesthesia: Is there any evidence? Crit Care 2014; 18:210
126. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS: Acute respiratory distress syndrome: The Berlin Definition. JAMA 2012; 307:2526-33
127. The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342:1301-8
128. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004; 351:327-36
129. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, Slutsky AS, Pullenayegum E, Zhou Q, Cook D, Brochard L, Richard JC, Lamontagne F, Bhatnagar N, Stewart TE, Guyatt G: Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: Systematic review and meta-analysis. JAMA 2010; 303:865-73
130. Borges JB, Okamoto VN, Matos GF, Caramez MP, Arantes PR, Barros F, Souza CE, Victorino JA, Kacmarek RM, Barbas CS, Carvalho CR, Amato MB: Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med 2006; 174:268-78
131. Serpa Neto A, Hemmes SN, Barbas CS, Beiderlinden M, Biehl M, Binnekade JM, Canet J, Fernandez-Bustamante A, Futier E, Gajic O, Hedenstierna G, Hollmann MW, Jaber S, Kozian A, Licker M, Lin WQ, Maslow AD, Memtsoudis SG, Reis Miranda D, Moine P, Ng T, Putensen C, Ranieri M, Scavonetto F, Schilling T, Schmid W, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ, Sprung J: Protective versus conventional ventilation for surgery: A systematic review and individual patient data meta-analysis. Anesthesiology 2015 [Epub ahead of print]