Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Singer, Mirko ^a   Marshall, Jennifer ^a   Heiss, Kirsten ^a,b   Mair, Gunnar R ^a   Grimm, Dirk ^a   Mueller, Ann Kristin ^a,c   Frischknecht, Friedrich ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MalVa GmbH   (Germany)

^c German Centre for Infectious Diseases (DZIF)   (Germany)

Author keywords

Alternative DNA repair; Alternative end joining; Apicomplexa; DSB; Genetically attenuated parasites; Malaria; Microhomology mediated end joining; Plasmodium; Vaccine; Zinc finger nucleases

Indexed keywords

ZINC FINGER NUCLEASE; DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME ARM; CONTROLLED STUDY; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; IMMUNIZATION; LIFE CYCLE; MICROHOMOLOGY MEDIATED END JOINING; MICROSCOPY; MOSQUITO; MOUSE; NONHUMAN; PLASMID; PLASMODIUM; PLASMODIUM BERGHEI; POLYMERASE CHAIN REACTION; PROTECTION; PROTEIN EXPRESSION; RODENT; SAFETY; SPOROZOITE; CHROMOSOME; GENE DELETION; GENETIC VARIATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM;

CHROMOSOMES; DEOXYRIBONUCLEASES; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; GENE DELETION; GENETIC VARIATION; PLASMODIUM BERGHEI; ZINC FINGERS;

EID: 84946919356     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0811-1     Document Type: Article

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