Acute promyelocytic leukemia: An experience on 95 Greek patients treated in the all-trans-retinoic acid era

Mediterranean Journal of Hematology and Infectious Diseases

Volumn 3, Issue 1, 2011, Pages 1-15

  Pagoni, Maria ^a   Garofalaki, Maria ^a   Panitsas, Fotios ^a   Manola, Kalliopi ^b   Psarra, Katerina ^a   Economopoulos, Panagiotis ^a   Vourtsi, Aggeliki ^a   Antoniades, Marios ^c   Gkirkas, Kostas ^d   Tzouvara, Evangelia ^e   Katis, Fotis ^f   Prokopiou, Chrystalla ^g   Tziotziou, Irene ^a   Balta, Artemis ^a   Lemissiou, Eleni ^c   Tsirigotis, Panagiotis ^d   Repoussis, Panagiotis ^f   Harhalakis, Nicolas ^a  

^a EVANGELISMOS HOSPITAL   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c NICOSIA GENERAL HOSPITAL   (Cyprus)

^d NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^e UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^f METAXA CANCER HOSPITAL   (Greece)

^g LIMASSOL GENERAL HOSPITAL   (Cyprus)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84946893992     PISSN: None     EISSN: 20353006     Source Type: Journal    
DOI: 10.4084/MJHID.2011.053     Document Type: Article

References (102)

1. Hillestad LK. Acute promyelocytic leukemia. Acta Med Scand 1957;159:189-194 http://dx.doi.org/10.1111/j.0954-6820.1957.tb00124.x
2. Bernard J, Mathe G, Boulay J, Ceoard B, Chome J. Acute promyelocytic leukemia: a study made on 20 cases. Schweiz Med Wochenschr 1959;89:604-608 PMid:13799642
3. Bennett JM, Catowsky D, Daniel MT, Flandrin G, Galton D, Gralnick M, Sultan C. Proposals for the classification of the acute leukemias: French-American-British (FAB) cooperative group. Br J Haematol 1976;33(4):451-458 http://dx.doi.org/10.1111/j.1365-2141.1976.tb03563.x PMid:188440
4. Bennet JM, Catowsky D, Daniel MT, Flandrin G, Galton D, Gralnick M, Sultan C. A variant form of hypergranular promyelocytic leukemia (M3). Br J Haematol 1980;44(1):169-170 http://dx.doi.org/10.1111/j.1365-2141.1980.tb01195.x PMid:6929699
5. Lo Coco F, Diverio D, Falini B, Biondi A, Nervi C, and Pelicci PG. Genetic Diagnosis and Molecular Monitoring in the Management of Acute Promyelocytic Leukemia. Blood 1999;94:12-22 PMid:10381493
6. Rowlay JD, Golomb HM, Dougherty C. 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukemia. Lancet 1977;1:549-550 http://dx.doi.org/10.1016/S0140-6736(77)91415-5
7. Larson RA, Kondo K, Vardiman JW, Butler ARE, Golomb HM, Rowley JD: Evidence for a (15;17) translocation in every patient with acute promyelocytic leukemia. Am J Med 1984;76:827 http://dx.doi.org/10.1016/0002-9343(84)90994-X
8. Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VV, Dmitrovsky E, Evans RM: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell 1991;66:663-74 http://dx.doi.org/10.1016/0092-8674(91)90112-C
9. Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I, Pelicci PG: The acute promyelocytic leukemia-specific PML-RARa fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 1993;74:423-31. http://dx.doi.org/10.1016/0092-8674(93)80044-F
10. Redner RL. Variations on a theme: the alternate translocations in APL. Leukemia 2002;16(10):1927-32 http://dx.doi.org/10.1038/sj.leu.2402720 PMid:12357344
11. Schoch C, Haase D, Haferlach T, Freund M, Link H, Lengfelder E, Löffler H, Büchner T, Fonatsch C: Incidence and implication of additional chromosome aberrations in acute promyelocytic leukaemia with translocation t(15;17)(q22;q21): a report on 50 patients. Br J Haematol 1996;94:493-500 http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1829.x PMid:8790148
12. De Botton S, Chevret S, Sanz M, Dombret H, Thomas X, Guerci A, Fey M, Rayon C, Huguet F, Sotto J, Gardin C, Makhoul PC, Travade P, Solary E, Fegueux N, Bordessoule D, San Miguel J, Link H, Desablens B, Stamatoulas A, Deconinck E, Geiser K, Hess U, Maloisel F, Castaigne S, Preudhomme C, Chomienne C, Degos L, Fenaux P. Additional chromosomal abnormalities in patients with acute promyelocytic leukaemia (APL) do not confer poor prognosis: results of APL 93 trial. Br J Haematol 2000;111:801- 806 http://dx.doi.org/10.1046/j.1365-2141.2000.02442.x PMid:11122141
13. Hernández JM, Martín G, Gutiérrez NC, Cervera J, Ferro MT, Calasanz MJ, Martínez-Climent JA, Luño E, Tormo M, Rayón C, Díaz-Mediavilla J, González M, González-San Miguel JD, Pérez- Equiza K, Rivas C, Esteve J, Alvarez Mdel C, Odriozola J, Ribera JM, Sanz MA; PETHA Cooperative Group, Spain: Additional cytogenetic changes do not influence the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with an ATRA plus anthracyclin based protocol. A report of the Spanish group PETHEMA. Haematologica 2001;86:807-13. PMid:11522536
14. Cervera J, Montesinos P, Hernández-Rivas JM, Calasanz MJ, Aventín A, Ferro MT, Luño E, Sánchez J, Vellenga E, Rayón C, Milone G, de la Serna J, Rivas C, González JD, Tormo M, Amutio E, González M, Brunet S, Lowenberg B, Sanz MA. Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Haematologica 2010;95(3):424-31. Epub 2009 Nov 10 http://dx.doi.org/10.3324/haematol.2009.013243 PMid:19903674 PMCid:2833072
15. Ono T, Takeshita A, Iwanaga M, Asou N, Naoe T, Ohno R; Japan Adult Leukemia Study Group. Impact of additional chromosomal abnormalities in patients with acute promyelocytic leukemia: 10- year results of the Japan Adult Leukemia Study Group APL97 study. Haematologica 2011;96(1):174-176. Epub 2010 Sep 30 http://dx.doi.org/10.3324/haematol.2010.030205 PMid:20884714 PMCid:3012784
16. Grimwade D, Howe K, Langabeer S, Davies L, Oliver F, Walker H, Swirsky D, Wheatley K, Goldstone A, Burnett A, Solomon E. Establishing the presence of the t(15;17) in suspected acute promyelocytic leukaemia: cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the M.R.C.ATRA trial. M.R.C. Adult Leukaemia Working Party. Br J Haematol 1996;94:557-573 PMid:8790159
17. David Grimwade. The significance of minimal residual disease in patients with t(15;17). Best Pract Res Clin Haematol 2002; 15(1):137-158 http://dx.doi.org/10.1053/beha.2002.0189
18. Reiter A, Saussele S, Grimwade D, Wiemels JL, Segal MR, Lafage-Pochitaloff M, Walz C, Weisser A, Hochhaus A, Willer A, Reichert A, Buchner T, Lengfelder E, Hehlmann R, and Cross NCP. Genomic Anatomy of the Specific Reciprocal Translocation t(15;17) in Acute Promyelocytic Leukemia. Genes, Chromosomes & Cancer 2003;36:175-188 http://dx.doi.org/10.1002/gcc.10154 PMid:12508246
19. Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, Walker H, Wheatley K, Bowen DT, Burnett AK, Goldstone AH, and Linch DC. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001; 98:1752-1759 http://dx.doi.org/10.1182/blood.V98.6.1752 PMid:11535508
20. Schnittger S, Schoch C, Dugas M, Kern W, Staib P, Wuchter C, Löffler H, Sauerland CM, Serve H, Büchner T, Haferlach T, and Hiddemann W. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 2002;100:59-66 http://dx.doi.org/10.1182/blood.V100.1.59 PMid:12070009
21. Kottaridis PD, Gale RE, Langabeer SE, Frew ME, Bowen DT, and Linch DC. Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood 2002; 100:2393-2398 http://dx.doi.org/10.1182/blood-2002-02-0420 PMid:12239147
22. Beitinjaneh A, Jang S, Roukoz H, Majhail NS. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute promyelocytic leukemia: a systematic review. Leuk Res 2010;34(7):831-836. Epub 2010 Jan 21 http://dx.doi.org/10.1016/j.leukres.2010.01.001 PMid:20096459
23. Mistry AR, Pedersen EW, Solomon E, Grimwade D. The molecular pathogenesis of acute promyelocytic leukemia: implications for the clinical management of the disease. Blood Rev 2003;17(2):71-97 http://dx.doi.org/10.1016/S0268-960X(02)00075-9
24. Lengfelder E, Saussele S, Weisser A, Buchner T, Hehlmann R: Treatment concepts of acute promyelocytic leukemia. Crit Rev Oncol Hematol 2005;56:261-274 http://dx.doi.org/10.1016/j.critrevonc.2004.08.009 PMid:16236522
25. Sirulnik LA, Stone RM: Acute promyelocytic leukemia: current strategies for the treatment of newly diagnosed disease. Clin Adv Hematol Oncol 2005;429:391-397
26. Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008;111(5):2505-2515 http://dx.doi.org/10.1182/blood-2007-07-102798 PMid:18299451
27. Sanz MA, Grimwade D, Tallman MS, Lowenberg R, Fenaux P, Estey EH, Naoe T, Lengfelder E, Büchner T, Döhner H, Burnett AK, and Lo-Coco F. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European Leukemia Net. Blood 2009;113:1875-1891 http://dx.doi.org/10.1182/blood-2008-04-150250 PMid:18812465
28. Tallman MS and Altman JK. How I treat acute promyelocytic leukemia. Blood 2009;114:5126-5135 http://dx.doi.org/10.1182/blood-2009-07-216457 PMid:19797519
29. Powell BL, Moser B, Stock W, Gallagher RE, Willman CL, Stone RM, Rowe JM, Coutre S, Feusner JH, Gregory J, Couban S, Appelbaum FR, Tallman MS, and Larson RA. Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. Blood 2010;116(19): 3751- 3757 http://dx.doi.org/10.1182/blood-2010-02-269621 PMid:20705755 PMCid:2981533
30. Adès L, Sanz MA, Chevret S, Montesinos P, Chevallier P, Raffoux E, Vellenga E, Guerci A, Pigneux A, Huguet F, Rayon C, Stoppa AM, de la Serna J, Cahn JY, Meyer-Monard S, Pabst T, Thomas X, de Botton S, Parody R, Bergua J, Lamy T, Vekhoff A, Negri S, Ifrah N, Dombret H, Ferrant A, Bron D, Degos L, and Fenaux P. Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results. Blood 2008;111:1078-1084 PMid:17975017
31. Sanz MA, Lo-Coco F. Modern approaches to treating acute promyelocytic leukemia. J Clin Oncol 2011;29(5):495-503 http://dx.doi.org/10.1200/JCO.2010.32.1067 PMid:21220600
32. Lehmann S, Ravn A, Carlsson L, Antunovic p, Deneberg S, Mollgard L, Rangert Derolf A, stockelberg D, Tibefelt U, Wahlin A, Wennstrom L, Hoglund M and Juliusson G. Continuing high early death rate in acute promyelocytic leukemia: a populationbased report from the Swedish Adult Acute Leukemia Registry. Leukemia 2011;25:1128-1134 http://dx.doi.org/10.1038/leu.2011.78 PMid:21502956
33. Park JH, Qiao B, Panageas KS, Schymura MJ, Jurcic JG, Rosenblat TL, Altman JK, Douer D, Rowe JM, and Tallman MS. Early death rate in acute promyelocytic leukemia remains high despite all-trans retinoic acid. Blood 2011;118(5):1248-1254 http://dx.doi.org/10.1182/blood-2011-04-346437 PMid:21653939
34. Sanz MA, Martin G, Rayon C, Esteve J, Gonzalez M, Diaz- Mediavilla J, Bolufer P, Barragan E, Terol MJ, Gonzalez JD, Colomer D, Chillon C, Rivas C, Gomez T, Ribera JM, Bornstein R, Roman J, Calasanz MJ, Arias J, Alvarez C, Ramos F, and Deben G for the PETHEMA Group. A Modified AIDA Protocol With Anthracycline-Based Consolidation Results in High Antileukemic Efficacy and Reduced Toxicity in Newly Diagnosed PML/RARa- Positive Acute Promyelocytic Leukemia. Blood 1999;94(9): 3015- 3021 PMid:10556184
35. Sanz MA, Martin G, Gonzalez M, Leon A, Rayon C, Rivas C, Colomer D, Amutio E, Capote FJ, Milone GA, de la Serna J, Roman J, Barragan E, Bergua J, Escoda L, Parody R, Negri S, Calasanz MJ, and Bolufer P. Risk adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA Group. Blood 2004;103(4):1237-1243 http://dx.doi.org/10.1182/blood-2003-07-2462 PMid:14576047
36. Latagliata R, Petti MC, Fenu S, Mancini M, Spiriti MAM, Breccia M, Brunetti GA, Avvisati G, Lo Coco F and Mandelli F. Therapyrelated myelodysplastic syndrome-acute myelogenous leukaemia in patients treated for acute promyelocytic leukaemia: an emerging problem. Blood 2002;99(3):822-824 http://dx.doi.org/10.1182/blood.V99.3.822 PMid:11806982
37. Zompi S, Viguie F. Therapy-related acute myeloid leukaemia and myelodysplasia after successful treatment of acute promyelocytic leukaemia. Leuk Lymphoma 2002;43:275-280 http://dx.doi.org/10.1080/10428190290006044
38. Stavroyianni N, Yataganas X, Abazis D, Pangalos C, Meletis J. Acute promyelocytic leukemia relapsing into FAB-M2 acute myeloid leukemia with trisomy 8. Cancer Genet Cytogenet 2000;117(1):82-83 http://dx.doi.org/10.1016/S0165-4608(99)00132-6
39. Matsouka P, Sambani C, Giannakoulas N, Symeonidis A, Zoumbos N. Polyploidy in acute promyelocytic leukemia without the 15:17 translocation. Haematologica 2001;86(12):1312-1313 PMid:11726325
40. Athanasiadou A, Saloum R, Zorbas I, Tsompanakou A, Batsis I, Fassas A, Anagnostopoulos A. Therapy-related myelodysplastic syndrome with monosomy 5 and 7 following successful therapy for acute promyelocytic leukemia with anthracyclines. Leuk Lymphoma 2002;43(12):2409-2411 http://dx.doi.org/10.1080/1042819021000040143
41. Manola KN, Karakosta M, Sambani C, Terzoudi G, Pagoni M, Gatsa E, Papaioannou M. Isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia resulting in an additional copy of the RARA-PML fusion gene: report of 4 cases and review of the literature. Acta Haematol 2010;123(3):162-170 http://dx.doi.org/10.1159/000294959 PMid:20224268
42. Sanz MA, Lo Coco F, Martin G, Avvisati G, Rayon C, Barbui T, Diaz-Mediavilla J, Fioritoni G, Gonzalez JD, Liso V, Esteve J, Ferrara F, Bolufer P, Bernasconi C, Gonzalez M, Rodeghiero F, Colomer D, Petti MC, Jose M. Ribera, and Franco Mandelli for the Spanish PETHEMA and the Italian GIMEMA Cooperative GroupsDefinition of relapse risk and role of non-anthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups. Blood 2000;96(4):1247-1253 PMid:10942364
43. Avvisati G, Lo-Coco F, Paoloni FP, Petti MC, Diverio D, Vignetti M, Latagliata R, Specchia G, Baccarani M, Di Bona E, Fioritoni G, Marmont F, Rambaldi A, Di Raimondo F, Kropp MG, Pizzolo G, Pogliani EM, Rossi G, Cantore N, Nobile F, Gabbas A, Ferrara F, Fazi P, Amadori S, Mandelli F, and for the GIMEMA, AIEOP, and EORTC Cooperative Groups. AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance. Blood 2011;117:4716-4725 http://dx.doi.org/10.1182/blood-2010-08-302950 PMid:21385856
44. Sanz MA, Montesinos P, Vellenga E, Rayon C, de la Serna J, Parody R, Bergua JM, Leon A, Negri S, Gonzalez M, Rivas C, Esteve J, Milone G, Gonzalez JD, Amutio E, Brunet S, García- Larana J, Colomer D, Calasanz MJ, Chillon C, Barragan E, Bolufer P, and Lowenberg Bob. Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoicacid and anthracycline monochemotherapy: long-term outcome of the LPA99 multicenter study by the PETHEMA Group. Blood 2008;112(8):3130-3134 http://dx.doi.org/10.1182/blood-2008-05-159632 PMid:18664623
45. Sanz MA, Montesinos P, Rayón C, Holowiecka A, de la Serna J, Milone G, de Lisa E, Brunet S, Rubio V, Ribera JM, Rivas C, Krsnik I, Bergua J, González J, Díaz-Mediavilla J, Rojas R, Manso F, Ossenkoppele G, González JD, and Lowenberg B. Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome. Blood 2010;115(25):5137-5146 http://dx.doi.org/10.1182/blood-2010-01-266007 PMid:20393132
46. Fenaux P, Le Deley MC, Castaigne S, Archimbaud E, Chomienne C, Link H, Guerci A, Duarte M, Daniel MT, Bowen D, Huebner G, Bauters F, Fegueux N, Fey M, Sanz M, Lowenberg B, Maloisel F, Auzanneau G, Sadoun A, Gardin C, Bastion Y, Ganser A, Jacky E, Dombret H, Chastang C, Degos L, and the European APL 91 Group. Effect of all transretinoic acid in newly diagnosed acute promyelocytic leukemia: results of a multicenter randomized trial. European APL 91 Group. Blood 1993;82(11):3241-3249 PMid:8241496
47. Fenaux P, Chastang C, Chevret S, Sanz M, Dombret H, Archimbaud E, Fey M, Rayon C, Huguet F, Sotto JJ, Gardin C, Makhoul PC, Travade P, Solary E, Fegueux N, Bordessoule D, San Miguel J, Link H, Desablens B, Stamatoullas A, E. Maloisel DF, Castaigne S, Preudhomme C, and Degos L for the European APL Group. A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia. Blood 1999;94(4):1192-1200 PMid:10438706
48. Ades L, Chevret S, Raffoux E, et al. Is cytarabine useful in the treatment of acute promyelocytic leukemia? results of a randomized trial from the European Acute Promyelocytic Leukemia Group. J Clin Oncol 2006;24:5703-5710 http://dx.doi.org/10.1200/JCO.2006.08.1596 PMid:17116939
49. Avvisati G, Petti M, Lo Coco F, Testi A, Fazi P. AIDA: the Italian way of treating acute promyelocytic leukemia (APL), final act [abstract]. Blood 2003;102:142a. Abstract#487
50. Asou N, Kishimoto Y, Kiyoi H, Okada M, Kawai Y, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Kobayashi T, Ohtake S, Nishimura M, Takahashi M, Yagasaki F, Takeshita A, Kimura Y, Iwanaga M, Naoe T, and Ohno R, for the Japan Adult Leukemia Study Group A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RAR_ transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study. Blood 2007;110(1):59-66 http://dx.doi.org/10.1182/blood-2006-08-043992 PMid:17374742
51. Adès L, Guerci A, Raffoux E, Sanz M, Chevallier P, Lapusan S, Recher C, Thomas X, Rayon C, Castaigne S, Tournilhac O, de Botton S, Ifrah N, Cahn JY, Solary E, Gardin C, Fegeux N, Bordessoule D, Ferrant A, Meyer-Monard S, Vey N, Dombret H, Degos L, Chevret S, Fenaux P, and for the European APL Group. Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience. Blood 2010;115:1690-1696 http://dx.doi.org/10.1182/blood-2009-07-233387 PMid:20018913
52. Evans GD, Grimwade DJ. Extramedullary disease in acute promyelocytic leukemia. Leuk Lymphoma 1999;33:219-229 PMid:10221502
53. E. Patatanian and D. F. Thompson. Retinoic acid syndrome: a review. J Clin Pharm Therap 2008;33:331-338 http://dx.doi.org/10.1111/j.1365-2710.2008.00935.x PMid:18613850
54. Tallman MS, Andersen JW, Schiffer CA, Appelbaum FR, Feusner JH, Woods WG, Ogden A, Weinsten H, Shepherd L, Willman C, Bloomfield CD, Rowe JM and Wiernik PH. All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol. Blood 2002;100:4298-4302 http://dx.doi.org/10.1182/blood-2002-02-0632 PMid:12393590
55. Wiley JS, Firkin FC. Reduction of pulmonary toxicity by prednisolone prophylaxis during all-trans retinoic acid treatment of acute promyelocytic leukemia. Leukemia 1995;9:774-778 PMid:7769839
56. G Avvisati, F Lo Coco, D Diverio, M Falda, F Ferrara, M Lazzarino, D Russo, MC Petti, and F MandelliAIDA (All trans retinoic acid plus idarubicin) in newly diagnosed acute promyelocytifc leukemia: a GIMEMA pilot study. Blood 1996;88(4):1390-1398 PMid:8695858
57. Mandelli F, Diverio D, Avvisati G, Luciano A, Barbui T, Bernasconi C, Broccia G, Cerri R, Falda M, Fioritoni G, Leoni F, Liso V, Petti MC, Rodeghiero F, Saglio G, Vegna ML, Visani G, Jehn U, Willemze R, Muus P, Pelicci PG, Biondi A, and Lo Coco F for the Gruppo Italiano Malattie Ematologiche Maligne dell' Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups. Molecular remission in PML/RARa-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Blood. 1997;90(3):1014-1021 PMid:9242531
58. Orfao A, Chillon MC, Bortoluci AM, Lopez-Berges MC, Garcia-Sanz R, Gonzalez M, Tabernero MD, García-Marcos MA, Rasillo AI, Hernández-Rivas J, San Miguel Jesús F. The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PMLRARalpha gene rearrangements. Haematologica 1999;84:405-412. PMid:10329918
59. Kakkas I, Psarra K, Kapsimali V, Garofalaki M, Pagoni M, Apostolidis I, Karmiris T, Nikiforakis E, Papasteriades C. Diagnostic value of acute promyelocytic leukaemia flow cytometry immunophenotyping. Haema 2005;8(4):641-643
60. Di Noto R, Mirabelli P and Del Vecchio L. Flow cytometry analysis of acute promyelocytic leukemia: the power of surface hematology. Leukemia 2007;21: 4-8. http://dx.doi.org/10.1038/sj.leu.2404412 PMid:17167527
61. MC Bene, T Nebe, P Bettelheim, B Buldini, H Bumbea, W Kern, F Lacombe, P Lemez, I Marinov, E Matutes, M Maynadie, U Oelschlagel, A Orfao, R Schabath, M Solenthaler, G Tschurtschenthaler, AM Vladareanu, G Zini, GC Faure and A Porwit. Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10. Leukemia 2011;25:567-574 http://dx.doi.org/10.1038/leu.2010.312 PMid:21252983
62. van Dongen JJM, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Gonzalez Diaz M, Malec M, Langerak AW, San Miguel JF and Biondi A. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease Leukemia 1999;13:1901-1928 http://dx.doi.org/10.1038/sj.leu.2401592 PMid:10602411
63. van der Velden VHJ, Hochhaus A, Cazzaniga G, Szczepanski T, Gabert J and van Dongen JJM. Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects, Leukemia 2003;17:1013-1034 http://dx.doi.org/10.1038/sj.leu.2402922 PMid:12764363
64. Gabert J, Beillard E, van der Velden VHJ, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cave H, Pane F, Aerts JLE, De Micheli D, Thirion X, Pradel V, Gonzalez M, Viehmann S, Malec M, Saglio G and van Dongen JJM. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - A Europe Against Cancer Program. Leukemia 2003;17:2318-2357 http://dx.doi.org/10.1038/sj.leu.2403135 PMid:14562125
65. Lo Coco F, Breccia M, Diverio D. The importance of molecular monitoring in acute promyelocytic leukemia. Best Pract Res Clin Haematol 2003;16(3):503-520 http://dx.doi.org/10.1016/S1521-6926(03)00041-0
66. Santamaría C, Chillón MC, Fernández C, Martín-Jiménez P, Balanzategui A, Sanz RG, San Miguel JF, Marcos-Gonzalez González. Using quantification of the PML-RARa transcript to stratify the risk of relapse in patients with acute promyelocytic leukemia. Haematologica 2007; 92:315-322 http://dx.doi.org/10.3324/haematol.10734 PMid:17339180
67. Garofalaki M, Pagoni M, Tziotziou I, Nikolou E, Nikiforakis E. The use of RQ-PCR according to "Europe against cancer (EAC)" program for the diagnosis of APL patients. 5th international symposium on acute promyelocytic leukemia, Rome 24-26 September 2009
68. Garofalaki M, Pagoni M, Tziotziou I, Nikolou E, Balta A, Vagia M, Tzannou I, Baltadakis I, Nikiforakis E. Real-time quantitative (RQ)-PCR by the europe against cancer (EAC) protocol in acute promyelocytic leukemia (APL), International symposium on minimal residual cancer, September 16-19, 2009, Athens Greece, Oral presentation, abstract #027 p.91)
69. Pagoni M, Garofalaki M, Tziotziou I, Nikolou E, Panitsas F, Bika I, Vourtsi A, Delimpassi S, Gigantes S, Harhalakis ?. Prognostic implication of FLT3 mutations in patients with acute promyelocytic leukemia, abstact# Acute leukemias XIII Biology and Treatment Strategies Munich, Germany February 27 - March 2, 2011
70. Cheson BD, Cassileth PA, Head DR, Schiffer CA, Bennet JM, Bloomfield CD, Brynning R, Gale RP, Grever MR, Keating MJ, Sawitsky A, Strass S, Weinstein H, Woods WG: Report of the National Cancer Institute-Sponsored Workshop on definition of diagnosis and response in acute myeloid leukemia. J Clin Oncol 1990;8:813-819 PMid:2185339
71. Lo-Coco F, Avvisati G, Vignetti M, Breccia M, Gallo E, Rambaldi A, Paoloni F, Fioritoni G, Ferrara F, Specchia G, Cimino G, Diverio D, Borlenghi E, Martinelli G, Di Raimondo F, Di Bona E, Fazi P, Peta A, Bosi A, Carella AM, Fabbiano F, Pogliani EM, Petti MC, Amadori S, Mandelli F, and for the Italian GIMEMA Cooperative Group Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group. Blood 2010;116:3171- 3179 http://dx.doi.org/10.1182/blood-2010-03-276196 PMid:20644121
72. Frankel SR, Eardley A, Lauwers G, Weiss M, and Warrell RP, Jr. The "retinoic Acid Syndrome" in Acute Promyelocytic Leukemia. An Intern Med 1992;117:292-296
73. De Botton S, Dombret H, Sanz M, San Miguel J, Caillot D, Zittoun R, Gardembas M, Stamatoulas A, Conde E, Guerci A, Gardin C, Geiser K, Cony Makhoul D, Reman O, de la Serna J, Lefrere F, Chomienne C, Chastang C, Degos L, Fenaux P, and the European APL Group. Incidence, Clinical Features, and Outcome of All Trans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute Promyelocytic Leukemia. Blood 1998;92: 2712-2718 PMid:9763554
74. Beaumont M, Sanz M, Carli PM, Maloisel F, Thomas X, Detourmignies L, Guerci A, Gratecos N, Rayon C, San Miguel J, Odriozola J, Cahn JY, Huguet F, Vekhof A, Stamatoulas A, Dombret H, Capote F, Esteve J, Stoppa AM, Fenaux P. Therapyrelated acute promyelocytic leukemia. J Clin Oncol 2003;21(11):2123-2137 http://dx.doi.org/10.1200/JCO.2003.09.072 PMid:12775738
75. Douglas A. Woo, MD; Robert H. Collins, MD; Howard S. Rossman, DO; Olaf Stüve, MD; Elliot M. Frohman, MD Mitoxantrone-Associated Leukemia in Multiple Sclerosis: Case Studies. Int J MS Care 2008;10:41-46
76. Mays AN, Osheroff N, Xiao Y, Wiemels JL, Felix CA, Byl JA, Saravanamuttu K, Peniket A, Corser R, Chang C, Hoyle C, Parker AN, Hasan SK, Lo-Coco F, Solomon E, Grimwade D. Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood 2010;115(2):326-30 http://dx.doi.org/10.1182/blood-2009-07-235051 Mid:19884644 PMCid:2808156
77. Montesinos P, González JD, González J, Rayón C, de Lisa E, Amigo ML, Ossenkoppele GJ, Peñarrubia MJ, Pérez-Encinas M, Bergua J, Debén G, Sayas MJ, de la Serna J, Ribera JM, Bueno J, Milone G, Rivas C, Brunet S, Löwenberg B, Sanz M. Therapyrelated myeloid neoplasms in patients with acute promyelocytic leukemia treated with all-trans-retinoic Acid and anthracyclinebased chemotherapy. J Clin Oncol 2010;28(24):3872-3879 http://dx.doi.org/10.1200/JCO.2010.29.2268 PMid:20625122
78. Ammatuna E, Montesinos P, Hasan SK, Ramadan SM, Esteve J, Hubmann M, Pagoni M, Grimwade D, Sanz MA, and Lo-Coco F. Presenting features and treatment outcome of acute promyelocytic leukemia arising after multiple sclerosis. Haematologica 2011;96(4):621-625 http://dx.doi.org/10.3324/haematol.2010.036657 PMid:21193421 PMCid:3069242
79. Nikolay D. Dimov, L. Jeffrey Medeiros, Farhad Ravandi, and Carlos E. Bueso-Ramos, Acute Promyelocytic Leukemia at Time of Relapse Commonly Demonstrates Cytogenetic Evidence of Clonal Evolution and Variability in Blast Immunophenotypic Features. Am J Clin Pathol 2010;133:484-490 http://dx.doi.org/10.1309/AJCPJ7K0AWMBHMAI PMid:20154288
80. N Stavroyianni, T Kalmantis, X Yataganas. Simultaneous PML/RARa and AML 1/ETO gene rearrangements in a patient with acute myeloid leukemia. Leukemia 1999;13(8):1294-1295 http://dx.doi.org/10.1038/sj.leu.2401455 PMid:10450762
81. Abreu e Lima RS, Baruffi MR, de Lima AS, de Oliveira FM, de Figueiredo-Pontes LL, Tone LG, Rogatto SR, Falcao RP, Ferrari Chauffaille Mde L, Rego EM. The co-expression of PML/RAR alpha and AML1/ETO fusion genes is associated with ATRA resistance. Br J Haematol 2005;128(3):407-409 http://dx.doi.org/10.1111/j.1365-2141.2004.05343.x PMid:15667548
82. Au WY, Fung A, Chim CS, Lie AK, Liang R, Ma ES, Chan CH, Wong KF, Kwong YL. FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact. Br J Haematol 2004;125(4):463-469 http://dx.doi.org/10.1111/j.1365-2141.2004.04935.x PMid:15142116
83. de la Serna J, Montesinos P, Vellenga E, Rayon C, Parody R, Leon A, Esteve J, Bergua JM, Milone G, Deben G, Rivas C, Gonzalez M, Tormo M, Diaz-Mediavilla J, Gonzalez JD, Negri S, Amutio E, Brunet S, Lowenberg B, and Sanz MA. Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin. Blood 2008;111(7):3395-3402 http://dx.doi.org/10.1182/blood-2007-07-100669 PMid:18195095
84. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu LJ, and Wang ZY. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988;72:567-572 PMid:3165295
85. Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, and Degos L. All-Trans Retinoic Acid as a Differentiation Therapy for Acute Promyelocytic Leukemia. I. Clinical Results. Blood 1990;76(9):1704-1709 PMid:2224119
86. Raymond P. Warrell Jr, Peter Maslak, Anna Eardliy, Glenn Heller, Wilson H. Miller Jr, and Stanley R Frankel. Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience. Leukemia 1994;8(6):929-933 PMid:8207986
87. Peter H. Wiernik, Phillip L.C. Banks, Delvyn C. Case Jr, Zalmen A. Arlin, Phillip O. Periman, Mary B. Todd, Paul S. Ritch, Robert E. Enck, and Alan B. Weitberg Cytarabine Plus Idarubicin or Daunorubicin as Induction and Consolidation Therapy for Previously Untreated Adult Patients With Acute Myeloid Leukemia. Blood 1992;79(2):313-319 PMid:1730080
88. Melnick A and Licht JD. Deconstructing a Disease: RARa, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia. Blood 1999;93(10):3167-3215 PMid:10233871
89. Sirulnik A, Melnick A, Zelent A, licht JD. Molecular pathogenesis of acute promyelocytic leykaemia and APL variants. Best Pract Res Clin Haematol. 2003;16(3):387-408 http://dx.doi.org/10.1016/S1521-6926(03)00062-8
90. Breccia M, Diverio D, Noguera NI, Visani G, Santoro A, Locatelli F, Damiani D, Marmont F, Vignetti M, Petti MC, Lo Coco F. Clinico-biological features and outcome of acute promyelocytic leukemia patients with persistent polymerase chain reactiondetectable disease after AIDA front-line induction and consolidation therapy. Haematologica 2004;89:29-33 PMid:14754603
91. Lo Coco F, Diverio D, Avvisati G, Petti MC, Meloni G, Pogliani EM, Biondi A, Rossi G, Carlo-Stella C, Selleri C, Martino B, Specchia G, and Mandelli F. Therapy of Molecular Relapse in Acute Promyelocytic Leukemia. Blood 1999;94:2225-2229 PMid:10498592
92. Lengfelder E, Lo-Coco F, Montesinos P, Grimwade D, Ades L, Kishore B, Pagoni M, Holowiecka A, Fenaux P, Sanz M, on behalf of the European LeukemiaNet. Treatment of relapsed acute promyelocytic leukaemia (APL) with Arsenic Trioxide. First results of the European Registry of Patients with Relapsed APL. Abstract Blood (ASH Annual Meeting Abstracts) 2010;116: (Abstract#15) Oral Session
93. Meloni G, Diverio D, Vignetti M, Avvisati G, Capria S, Petti MC, Mandelli F, and Lo Coco F. Autologous Bone Marrow Transplantation for Acute Promyelocytic Leukemia in Second Remission: Prognostic Relevance of Pretransplant Minimal Residual Disease Assessment by Reverse-Transcription Polymerase Chain Reaction of the PML/RARa Fusion Gene. Blood 1997;90(3):1321-1325 PMid:9242568
94. Lobe I, Rigal-Huguet F, Vekhoff A, Desablens B, Bordessoule D, Mounier C, Ferrant A, Sanz M, Fey M, Chomienne C, Chevret S, Degos L and Fenaux P for the European APL group. Myelodysplastic syndrome after acute promyelocytic leukemia: the European APL group experience. Leukemia 2003;17(8):1600-1604 http://dx.doi.org/10.1038/sj.leu.2403034 PMid:12886249
95. Larson RS, Brown DC, Sklar LA. Retinoic acid induces aggregation of the acute promyelocytic leukemia cell line NB-4 by utilization of LFA-1 and ICAM-2. Blood 1997;90(7):2747 PMid:9326242
96. Ito S, Ishida Y, Oyake T, Satoh M, Aoki Y, Kowata S, Uchiyama T, Enomoto S, Sugawara T, Numaoka H, Suzuki K, Murai K. Clinical and biological significance of CD56 antigen expression in acute promyelocytic leukaemia. Leuk Lymphoma 2004;45(9):1783-1789 http://dx.doi.org/10.1080/10428190410001683624
97. Stavropoulou C, Georgakakos VN, Manola KN, Pagoni M, Garofalaki M, Pantelias GE, Sambani C: 5'RARA submicroscopic deletion from new variant translocation involving chromosomes 15, 17, and 18, in a case of acute promyelocytic leukemia. Cancer Genet Cytogenet 2008;182:50-5. http://dx.doi.org/10.1016/j.cancergencyto.2007.12.011 PMid:18328952
98. Stock W, Najib K, Moser BK, Powell BL, Holowka N, Gulati K, Bloomfield CD, Larson RA, Sher D. High incidence of FLT3 mutations in adults with acute promyelocytic leukaemia (APL): Correlation with diagnostic features and treatment outcome (CALGB9710) abstract#7002, J Clin Oncol 2008;26:suppl abstr 7002
99. Singh H, Werner L, Deangelo D, Ballen K, Amrein P, Wadleigh M, Neuberg D, Fox E, Stone R, Attar E. Clinical outcome of patients with acute promyelocytic leukemia and FLT3 mutations. Am J Hematol 2010;85(12):956-957 http://dx.doi.org/10.1002/ajh.21867 PMid:20981678
100. Joseph G. Jurcic, Stephen D. Nimer, David A. Scheinberg, Tony DeBlasio, Raymond P. Warrell, Jr, and Wilson H. Miller, Jr. Prognostic significance of minimal residual disease detection and PML/RAR-a isoform type: long-term follow-up in acute promyelocytic leukemia. Blood 2001;98:2651-2656 PMid:11675334
101. Grimwade D, Lo Coco F. Acute promyelocytic leukemia: a model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia. Leukemia 2002;16(10):1959-1973 http://dx.doi.org/10.1038/sj.leu.2402721 PMid:12357347
102. Reiter A, Lengfelder E, Grimwade D. Pathogenesis, diagnosis and monitoring of residual disease in acute promyelocytic leukemia. Acta Haematol 2004;112(1-2):55-67 http://dx.doi.org/10.1159/000077560 PMid:15179005