Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Frontiers in Microbiology

Volumn 6, Issue SEP, 2015, Pages

  Aziz, Ramy K ^a,b   Khaw, Valerie L ^b   Monk, Jonathan M ^b   Brunk, Elizabeth ^b   Lewis, Robert ^c   Loh, Suh I ^d   Mishra, Arti ^d   Nagle, Amrita A ^d   Satyanarayana, Chitkala ^d   Dhakshinamoorthy, Saravanakumar ^d   Luche, Michele ^c   Kitchen, Douglas B ^c   Andrews, Kathleen A ^b   Palsson, Bernhard O ^b   Charusanti, Pep ^b,e  

^a CAIRO UNIVERSITY   (Egypt)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c ALBANY MOLECULAR RESEARCH INC   (United States)

^d Pte Ltd   (Singapore)

^e Chalmers University of Technology   (Denmark)

Author keywords

Antibiotic development; Bacterial metabolism; Drug discovery; Metabolic reconstruction; Model based drug target discovery; Pathway gap filling; Synthetic lethality; Systems biology

Indexed keywords

AMIKACIN; AMPICILLIN; AZITHROMYCIN; CEFTRIAXONE; CHLORAMPHENICOL; GLYCOLALDEHYDE DEHYDROGENASE; KANAMYCIN; LEVOFLOXACIN; PRION PROTEIN; TETRACYCLINE;

ALDA GENE; ARTICLE; ESCHERICHIA COLI; EXPRESSION VECTOR; GENE; GROWTH RATE; HIGH THROUGHPUT SCREENING; IC50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRPC GENE; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; TRANSPOSON;

EID: 84946741914     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00958     Document Type: Article

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