Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents

Cell Death and Disease

Volumn 6, Issue , 2015, Pages

  Yadav, N ^a   Kumar, S ^a   Marlowe, T ^a   Chaudhary, A K ^a   Kumar, R ^a   Wang, J ^a   O'Malley, J ^a   Boland, P M ^a   Jayanthi, S ^b   Kumar, T K S ^b   Yadava, N ^c   Chandra, D ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ARKANSAS   (United States)

^c Pioneer Valley Life Sciences Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APICIDIN; CASPASE; CYTOCHROME C; DOXORUBICIN; ETOPOSIDE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; PACLITAXEL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SORAFENIB; STAUROSPORINE; THAPSIGARGIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; BIOGENESIS; CANCER CELL; COMPLEX I DEFICIENCY; COMPLEX II DEFICIENCY; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SYNTHESIS; UNFOLDED PROTEIN RESPONSE; WILD TYPE; DRUG EFFECTS; GENETICS; METABOLISM; NEOPLASMS; PATHOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; HUMANS; NEOPLASMS; OXIDATIVE PHOSPHORYLATION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84946600921     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.305     Document Type: Article

References (51)

1. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
2. Yadav N, Chandra D. Mitochondrial and postmitochondrial survival signaling in cancer. Mitochondrion 2014; 16: 18-25.
3. Gaude E, Frezza C. Defects inmitochondrial metabolism and cancer. Cancer Metab 2014; 2: 10.
4. Li QX, Yu DH, Liu G, Ke N, McKelvy J, Wong-Staal F. Selective anticancer strategies via intervention of the death pathways relevant to cell transformation. Cell Death Differ 2008; 15: 1197-1210.
5. Fulda S, Kroemer G. Mitochondria as therapeutic targets for the treatment of malignant disease. Antioxid Redox Signal 2011; 15: 2937-2949.
6. Sarosiek KA, Ni Chonghaile T, Letai A. Mitochondria: gatekeepers of response to chemotherapy. Trends Cell Biol 2013; 23: 612-619.
7. Kang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 2009; 15: 1126-1132.
8. Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 2013; 19: 202-208.
9. Davids MS, Letai A. ABT-199: A new hope for selective Bcl2 inhibition. Cancer Cell 2013; 23: 139-141.
10. Dey R, Moraes CT. Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bclx( L) in osteosarcoma cells. J Biol Chem 2000; 275: 7087-7094.
11. Chandra D, Liu JW, Tang DG. Early mitochondrial activation and cytochrome c up-regulation during apoptosis. J Biol Chem 2002; 277: 50842-50854.
12. Yadav N, Chandra D, Mitochondrial DNA. Mutations and breast tumorigenesis. Biochim Biophys Acta 2013; 1836: 336-344.
13. Chandra D, Singh KK. Genetic insights into OXPHOS defect and its role in cancer. Biochim Biophys Acta 2011; 1807: 620-625.
14. Wallace DC. Mitochondria and cancer. Nat Rev Cancer 2012; 12: 685-698.
15. Chandra D, Tang DG. Mitochondrially localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated procaspase-9 activation in the mitochondria. J Biol Chem 2003; 278: 17408-17420.
16. Juin P, Pelletier M, Oliver L, Tremblais K, Gregoire M, Meflah K et al. Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cellfree system. The Journal of biological chemistry 1998; 273: 17559-17564.
17. Yadav N, Pliss A, Kuzmin A, Rapali P, Sun L, Prasad P et al. Transformations of the macromolecular landscape at mitochondria during DNA-damage-induced apoptotic cell death. Cell Death Dis 2014; 5: e1453.
18. Lebedeva MA, Eaton JS, Shadel GS. Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta 2009; 1787: 328-334.
19. Compton S, Kim C, Griner NB, Potluri P, Scheffler IE, Sen S et al. Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J Biol Chem 2011; 286: 20297-20312.
20. Boohaker RJ, Zhang G, Carlson AL, Nemec KN, Khaled AR. BAX supports the mitochondrial network, promoting bioenergetics in nonapoptotic cells. Am J Physiol Cell Physiol 2011; 300: C1466-C1478.
21. Yang M, Luna L, Sorbo JG, Alseth I, Johansen RF, Backe PH et al. Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. Free Radic Biol Med 2014; 77: 41-48.
22. Fujisawa K, Nishikawa T, Kukidome D, Imoto K, Yamashiro T, Motoshima H et al. TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis. Biochem Biophys Res Commun 2009; 379: 43-48.
23. Suliman HB, Carraway MS, Welty-Wolf KE, Whorton AR, Piantadosi CA. Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. J Biol Chem 2003; 278: 41510-41518.
24. Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M et al. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet 2001; 28: 223-231.
25. Kaguni LS. DNA polymerase gamma, the mitochondrial replicase. Annu Rev Biochem 2004; 73: 293-320.
26. Dewaele M, Maes H, Agostinis P. ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy 2010; 6: 838-854.
27. Wu CC, Bratton SB. Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal 2013; 19: 546-558.
28. Au HC, Seo BB, Matsuno-Yagi A, Yagi T, Scheffler IE. The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. Proc Natl Acad Sci USA 1999; 96: 4354-4359.
29. Ditta G, Soderberg K, Scheffler IE. Chinese hamster cell mutant with defective mitochondrial protein synthesis. Nature 1977; 268: 64-67.
30. Prabhu V, Srivastava P, Yadav N, Amadori M, Schneider A, Seshadri A et al. Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. Mitochondrion 2013; 13: 493-499.
31. Ditta G, Soderberg K, Landy F, Scheffler IE. The selection of Chinese hamster cells deficient in oxidative energy metabolism. Somatic Cell Genet 1976; 2: 331-344.
32. Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA et al. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 2009; 139: 149-160.
33. Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK et al. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity 2013; 39: 311-323.
34. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012; 36: 401-414.
35. Ricci JE, Waterhouse N, Green DR. Mitochondrial functions during cell death, a complex (I-V) dilemma. Cell Death Differ 2003; 10: 488-492.
36. Garrido N, Griparic L, Jokitalo E, Wartiovaara J, van der Bliek AM, Spelbrink JN. Composition and dynamics of human mitochondrial nucleoids. Mol Biol Cell 2003; 14: 1583-1596.
37. Kulawiec M, Ayyasamy V, Singh KK. p53 regulates mtDNA copy number and mitocheckpoint pathway. J Carcinog 2009; 8: 8.
38. Achanta G, Sasaki R, Feng L, Carew JS, Lu W, Pelicano H et al. Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. EMBO J 2005; 24: 3482-3492.
39. Lenaz G. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 2001; 52: 159-164.
40. Singh KK, Russell J, Sigala B, Zhang Y, Williams J, Keshav KF Mitochondrial DNA. determines the cellular response to cancer therapeutic agents. Oncogene 1999; 18: 6641-6646.
41. Fu X, Wan S, Lyu YL, Liu LF, Qi H. Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS One 2008; 3: e2009.
42. Liu X, Chhipa RR, Pooya S, Wortman M, Yachyshin S, Chow LM et al. Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci USA 2014; 111: E435-E444.
43. Yadava N, Potluri P, Scheffler IE. Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly. Int J Biochem Cell Biol 2008; 40: 447-460.
44. Potluri P, Yadava N, Scheffler IE. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur J Biochem 2004; 271: 3265-3273.
45. Chen J, Kadlubar FF, Chen JZ. DNA supercoiling suppresses real-time PCR: a new approach to the quantification of mitochondrial DNA-damage and repair. Nucleic Acids Res 2007; 35: 1377-1388.
46. Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res 1996; 6: 986-994.
47. Xia P, An HX, Dang CX, Radpour R, Kohler C, Fokas E et al. Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer. BMC Cancer 2009; 9: 454.
48. Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 2012; 7: 562-578.
49. Kraaij MD, Savage ND, van der Kooij SW, Koekkoek K, Wang J, van den Berg JM et al. Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America 2010; 107: 17686-17691.
50. Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011; 208: 519-533.
51. Esposti MD, Hatzinisiriou I, McLennan H, Ralph S. Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes. J Biol Chem 1999; 274: 29831-29837.