Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21

Free Radical Biology and Medicine

Volumn 77, Issue , 2014, Pages 41-48

  Yang, Mingyi ^a,b   Luna, Luisa ^a   Sørbø, Jan Gunnar ^a,b   Alseth, Ingrun ^a   Johansen, Rune F ^a   Backe, Paul H ^a,b   Danbolt, Niels C ^a   Eide, Lars ^b   Bjørås, Magnar ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

DNA damage; Free radicals; GPX2; HO 1; Mitochondria; Oxidative stress; OXR1; p21; ROS

Indexed keywords

ANTIOXIDANT; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; PROTEIN OXR1; PROTEIN P21; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; OXR1 PROTEIN, HUMAN; PROTEIN;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GPX2 GENE; HO 1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; P21 GENE; SIGNAL TRANSDUCTION; UPREGULATION; GENE DOSAGE; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; PHYSIOLOGY;

ANTIOXIDANTS; APOPTOSIS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA, MITOCHONDRIAL; GENE DOSAGE; GENE EXPRESSION; HEK293 CELLS; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; OXIDATIVE STRESS; PROTEINS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84908404006     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.09.003     Document Type: Article

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