Plasticity beyond cancer cells and the immunosuppressive switch

Cancer Research

Volumn 75, Issue 21, 2015, Pages 4441-4445

  Granot, Zvi ^a   Fridlender, Zvi G ^b  

^a HEBREW UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

CANCER CELL; CANCER GROWTH; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; IMMUNOCOMPETENT CELL; LYMPHOCYTE PROLIFERATION; MACROPHAGE; NEUTROPHIL; NONHUMAN; PERICYTE; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STROMA CELL; TUMOR ASSOCIATED NEUTROPHIL; TUMOR IMMUNOLOGY; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; UPREGULATION; CELL PLASTICITY; CELL TRANSFORMATION; DISEASE COURSE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; NEOPLASM; PATHOLOGY; PHENOTYPE; PHYSIOLOGY;

CELL PLASTICITY; CELL TRANSFORMATION, NEOPLASTIC; DENDRITIC CELLS; DISEASE PROGRESSION; HUMANS; IMMUNE TOLERANCE; MACROPHAGES; NEOPLASMS; NEUTROPHILS; PHENOTYPE; T-LYMPHOCYTES, CYTOTOXIC; TUMOR MICROENVIRONMENT;

EID: 84946592868     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-1502     Document Type: Review

References (38)

1. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
2. Sagiv Jitka Y, Michaeli J, Assi S, Mishalian I, Kisos H, Levy L, et al. Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer. Cell Rep 2015;10:562-73.
3. Sionov RV, Fridlender ZG, Granot Z. The multifaceted roles neutrophils play in the tumor microenvironment. Cancer Microenviron 2014 Jun 4. [Epub ahead of print].
4. Coffelt SB, Kersten K, Doornebal CW, Weiden J, Vrijland K, Hau CS, et al. IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Nature 2015;522:345-8.
5. De Kleijn S, Langereis JD, Leentjens J, Kox M, Netea MG, Koenderman L, et al. IFN-gamma-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1. PloS One 2013;8: e72249.
6. Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 2009;16:183-94.
7. Granot Z, Henke E, Comen EA, King TA, Norton L, Benezra R. Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 2011;20:300-14.
8. Lopez-Lago MA, Posner S, Thodima VJ, Molina AM, Motzer RJ, Chaganti RS. Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression. Oncogene 2013;32:1752-60.
9. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006;313:1960-4.
10. Rudensky AY. Regulatory T cells and Foxp3. Immunol Rev 2011;241: 260-8.
11. Jarnicki AG, Lysaght J, Todryk S, Mills KH. Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4 and CD8 regulatory T cells. J Immunol 2006;177:896-904.
12. Lotze MT. Getting to the source: dendritic cells as therapeutic reagents for the treatment of patients with cancer. Ann Surg 1997;226:1-5.
13. Thompson ED, Enriquez HL, Fu YX, Engelhard VH. Tumormasses support naive T cell infiltration, activation, and differentiation into effectors. J Exp Med 2010;207:1791-804.
14. Ma Y, Shurin GV, Peiyuan Z, Shurin MR. Dendritic cells in the cancer microenvironment. J Cancer 2013;4:36-44.
15. Biswas SK, Sica A, Lewis CE. Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J Immunol 2008;180:2011-7.
16. Mantovani A, Germano G, Marchesi F, Locatelli M, Biswas SK. Cancerpromoting tumor-associated macrophages: new vistas and open questions. Eur J Immunol 2011;41:2522-5.
17. Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013;229:176-85.
18. Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 2012;12:253-68.
19. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003;3:23-35.
20. Hagemann T, Wilson J, Burke F, Kulbe H, Li NF, Pluddemann A, et al. Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol 2006;176:5023-32.
21. DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, et al. CD4() T cells regulate pulmonary metastasis ofmammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009;16: 91-102.
22. Ruffell B, Affara NI, Coussens LM. Differential macrophage programming in the tumor microenvironment. Trends Immunol 2012;33:119-26.
23. Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51.
24. Klimp AH, De Vries EG, Scherphof GL, Daemen T. A potential role of macrophage activation in the treatment of cancer. Crit Rev Oncol/Hematol 2002;44:143-61.
25. Fridlender ZG, Albelda SM. Modifying tumor-associated macrophages: An important adjunct to immunotherapy.Oncoimmunology 2013;2:e26620.
26. Fridlender ZG, Jassar A, Mishalian I, Wang LC, Kapoor V, Cheng G, et al. Using macrophage activation to augment immunotherapy of established tumours. Br J Cancer 2013;108:1288-97.
27. Augsten M. Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment. Front Oncol 2014;4:62.
28. Slany A, Haudek-Prinz V, Meshcheryakova A, Bileck A, Lamm W, Zielinski C, et al. Extracellular matrix remodeling by bone marrow fibroblast-like cells correlates with disease progression in multiple myeloma. J Proteome Res 2014;13:844-54.
29. Flavell SJ, Hou TZ, Lax S, Filer AD, Salmon M, Buckley CD. Fibroblasts as novel therapeutic targets in chronic inflammation. Br J Pharmacol 2008;153:S241-6.
30. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006;6: 392-401.
31. Chang HY, Chi JT, Dudoit S, Bondre C, van De Rijn M, Botstein D, et al. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci U S A 2002;99:12877-82.
32. De Wever O, Demetter P, Mareel M, Bracke M. Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 2008;123:2229-38.
33. Polanska UM, Orimo A. Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol 2013;228:1651-7.
34. Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, et al. Pancreatic cancer-associated stellate cells promote differentiation ofmyeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res 2013;73: 3007-18.
35. Flaberg E, Markasz L, Petranyi G, Stuber G, Dicso F, Alchihabi N, et al. Highthroughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts. Int J Cancer 2011;128:2793-802.
36. van Meeteren LA, ten Dijke P. Regulation of endothelial cell plasticity by TGF-beta. Cell Tissue Res 2012;347:177-86.
37. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3:401-10.
38. Kelly-Goss MR, Sweat RS, Stapor PC, Peirce SM, Murfee WL. Targeting pericytes for angiogenic therapies. Microcirculation 2014;21:345-57.