Composite sequence-structure stability models as screening tools for identifying vulnerable targets for HIV drug and vaccine development

Viruses

Volumn 7, Issue 11, 2015, Pages 5718-5735

  Manocheewa, Siriphan ^a   Mittler, John E ^a   Samudrala, Ram ^a   Mullins, James I ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Capsid protein (CA); Destabilizing mutations; HIV 1; Point mutation modeling; Protein structural stability prediction; Tolerated sequence space

Indexed keywords

ALANINE; ANTIRETROVIRUS AGENT; CAPSID PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VACCINE; VIRUS PROTEIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; COMPOSITE SEQUENCE STRUCTURE STABILITY MODEL; COMPUTER PROGRAM; DRUG RESEARCH; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; MUTAGENESIS; NONHUMAN; PROTEIN STABILITY; PROTEIN STRUCTURE; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS LOAD; BIOLOGY; CONSERVED SEQUENCE; DRUG DEVELOPMENT; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; ISOLATION AND PURIFICATION; MASS SCREENING; PROCEDURES;

AIDS VACCINES; ANTI-HIV AGENTS; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; DRUG DISCOVERY; HIV ANTIGENS; HIV-1; HUMANS; MASS SCREENING; PROTEIN STABILITY;

EID: 84946575612     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7112901     Document Type: Article

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