Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 22, 2014, Pages 8233-8238

  Bharata, Tanmay A M ^a,b,c   Menendez, Luis R Castillo ^b,f   Hagena, Wim J H ^a   Luxd, Vanda ^b,g   Igonete, Sebastien ^d,e,h   Schorba, Martin ^a   Schura, Florian K M ^a,b   Kraüsslich, Hans Georg ^b   Briggsa, John A G ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d INSTITUT PASTEUR   (France)

^e CNRS   (France)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g UNIVERSITY OF DUISBURG ESSEN   (Germany)

^h Calixar SAS   (France)

Author keywords

Cryo electron tomography; Electron cryomicroscopy; Helical reconstruction; SP1

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS 1 GAG PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; CUCUMBER MOSAIC VIRUS; ELECTRON MICROSCOPY; ELECTRON TOMOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMAGE PROCESSING; IMMATURE VIRUS; IN VITRO STUDY; MASON PFIZER MONKEY VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PURIFICATION; VIRUS ASSEMBLY; VIRUS CAPSID; X RAY CRYSTALLOGRAPHY;

CRYO-ELECTRON TOMOGRAPHY; ELECTRON CRYOMICROSCOPY; HELICAL RECONSTRUCTION; SP1;

CAPSID PROTEINS; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; NANOTUBES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; VIRION;

EID: 84901846907     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1401455111     Document Type: Article

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