Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites

Diabetologia

Volumn 58, Issue 12, 2015, Pages 2781-2790

  Nakatochi, Masahiro ^a   Ichihara, Sahoko ^b   Yamamoto, Ken ^c   Ohnaka, Keizo ^d   Kato, Yosuke ^e   Yokota, Shigeki ^f   Hirashiki, Akihiro ^g   Naruse, Keiko ^h   Asano, Hiroyuki ^f   Izawa, Hideo ⁱ   Matsubara, Tatsuaki ^h   Yokota, Mitsuhiro ^h  

^a NAGOYA UNIVERSITY HOSPITAL   (Japan)

^b MIE UNIVERSITY   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e Tokai Women's Junior College   (Japan)

^f Iwakura Hospital   (Japan)

^g NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h AICHI GAKUIN UNIVERSITY   (Japan)

ⁱ FUJITA HEALTH UNIVERSITY BANTANE HOSPITAL   (Japan)

Author keywords

Cohort study; DNA methylation; Epigenetics; Epigenome wide association study; Resistin; Single nucleotide polymorphism

Indexed keywords

HEMOGLOBIN A1C; RESISTIN; RETN PROTEIN, HUMAN;

AGED; ALLELE; ARTICLE; BODY MASS; CHROMOSOME 19; CPG ISLAND; DNA FLANKING REGION; DNA METHYLATION; EPIGENETICS; FEMALE; FLANKING REGION OF THE RESISTIN GENE; GENE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; MONOCYTE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN CONTINENTAL ANCESTRY GROUP; CROSS-SECTIONAL STUDY; GENETIC EPIGENESIS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; MIDDLE AGED;

AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CROSS-SECTIONAL STUDIES; DNA METHYLATION; EPIGENESIS, GENETIC; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RESISTIN;

EID: 84946493966     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3763-9     Document Type: Article

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