Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator- activating receptor gamma (PPARγ)

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Singh, Anil K ^a   Battu, Aruna ^b   Mohareer, Krishnaveni ^a   Hasnain, Seyed E ^a,c   Ehtesham, Nasreen Z ^a,b  

^a UNIVERSITY OF HYDERABAD   (India)

^b NATIONAL INSTITUTE OF NUTRITION   (India)

^c JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESISTIN; TRANSCRIPTION FACTOR SP1;

ANIMAL; ARTICLE; BINDING SITE; CELL NUCLEUS; CELL STRAIN 3T3; CELL STRAIN U937; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; METABOLISM; MOLECULAR CLONING; MOUSE; PROMOTER REGION;

3T3 CELLS; ANIMALS; BINDING SITES; CELL NUCLEUS; CLONING, MOLECULAR; CYSTEINE; GENE EXPRESSION REGULATION; HUMANS; MICE; PPAR GAMMA; PROMOTER REGIONS, GENETIC; RESISTIN; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; U937 CELLS;

EID: 79952117555     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009912     Document Type: Article

References (68)

1. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, et al. (2000) FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 19: 4046-4055.
2. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, et al. (2001) The hormone resistin links obesity to diabetes. Nature 409: 307-312.
3. Nagaev I, Smith U (2001) Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 285: 561-564.
4. Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, et al. (2001) Resistin/fizz3 expression in relation to obesity and peroxisome proliferatoractivated receptor-gamma action in humans. Diabetes 50: 2199-2202.
5. Ehtesham NZ (2001) Molecular link between diabetes and obesity: The resistin story. Curr Sci 80: 1369-1371.
6. Ehtesham NZ (2002) Does resistin resist insulin? Curr Sci 83: 1190-1191.
7. Janke J, Engeli S, Gorzelniak K, Luft FC, Sharma AM (2002) Resistin gene expression in human adipocytes is not related to insulin resistance. Obes Res 10: 1-5.
8. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, et al. (2003) Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab 88: 4848-4856.
9. Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, et al. (2004) Relationship between serum resistin concentrations and insulin resistance in non-obese, obese, and obese diabetic subjects. J Clin Endocrinol Metab 89: 1844-1848.
10. Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, et al. (2003) Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun 300: 472-476.
11. Lu SC, Shieh WY, Chen CY, Hsu SC, Chen HL (2002) Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Lett 530: 158-162.
12. Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, et al. (2003) Resistin messenger-RNA expression is increased by pro-inflammatory cytokines in vitro. Biochem Biophys Res Commun 309: 286-290.
13. Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, et al. (2004) An Inflammatory Cascade Leading to Hyperresistinemia in Humans. PLoS Med 1: e45.
14. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, et al. (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111: 932-939.
15. Silswal N, Singh AK, Aruna B, Mukhopadhyay S, Ghosh S, et al. (2005) Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem. Biophys Res Commun 334: 1092-1101.
16. Dahlman I, Kaaman M, Olsson T, Tan GD, Bickerton AS, et al. (2005) A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 90: 5834-5840.
17. Coppack SW (2001) Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 60: 349-356.
18. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, et al. (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394: 897-901.
19. Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil, GS (2005) The Fatty Acid-binding Protein, aP2, co-ordinates macrophage cholesterol trafficking and inflammatory activity: macrophage expression of aP2 impacts peroxisome proliferator-activated receptor λ and IκB kinase activities. J Biol Chem 280: 12888-12895.
20. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, et al. (2001) The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med 7: 41-47.
21. Hartman HB, Hu X, Tyler KX, Dalal CK, Lazar M A (2002) Mechanisms regulating adipocyte expression of resistin. J Biol Chem 277: 19754-19761.
22. Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, et al. (2003) Functional characterization of the human resistin promoter with adipocyte determinationand differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha. Mol Endocrinol 17: 1522-1533.
23. Tomaru T, Steger DJ, Lefterova MI, Schupp M, Lazar MA (2009) Adipocytespecific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancerbinding proteins. J Biol Chem 284: 6116-6125.
24. Song H, Shojima N, Sakoda H, Ogihara T, Fujishiro M, et al. (2002) Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules. Biochem Biophys Res Commun 299: 291-298.
25. Zhou L, Xia T, Li Y, Chen X, Peng Y, et al. (2006) Transcriptional regulation of the resistin gene. Domest Anim Endocrinol 30: 98-107.
26. Ghosh S, Singh AK, Aruna B, Mukhopadhyay S, Ehtesham NZ (2003) The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications. Gene 305: 27-34.
27. Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-148.
28. Bradford MM (1976) A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. Analytical Biochem 72: 248-254.
29. Smale ST, Baltimore D (1989) The "initiator" as a transcription control element. Cell 57: 103-113.
30. Mukherjee B, Burma S, Hasnain SE (1995) An unusual 30-kDa protein binding to the polyhedrin gene promoter of Autographa californica nuclear polyhedrosis virus. J Biol Chem 270: 4405-4411.
31. Ramachandran A, Jain A, Arora P, Bashyam MD, Chatterjee U, et al. (2001) J Biol Chem 276: 23440-23449.
32. Burma S, Mukherjee B, Jain A, Habib S, Hasnain SE (1994) A 38-kDa Host Factor Interacts with Functionally Important Motifs within the Autographa californica Multinucleocapsid Nuclear Polyhedrosis Virus Homologous Region (hr1) DNA Sequence. J Biol Chem 269: 2750-2757.
33. Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, et al. (2001) Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Proc Natl Acad Sci U S A 98 (18): 10380-5.
34. Pugh BF, Tjian R (1990) Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 61: 1187-1197.
35. Karlseder J, Rotheneder H, Wintersberger E (1996) Interaction of Sp1 with the growth-and cell cycle-regulated transcription factor E2F. Mol Cell Biol 16: 1659-1667.
36. Braun H, Suske G (1998) Combinatorial action of HNF3 and Sp family transcription factors in the activation of the rabbit uteroglobin/CC10 promoter. J Biol Chem 273: 9821-9828.
37. Krey G, Mahfoudi A, Wahli W (1995) Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Sp1 in the transcriptional regulation of the acyl-coenzyme-A oxidase promoter. Mol Endocrinol 9: 219-231.
38. Look DC, Pelletier MR, Tidwell RM, Roswit WT, Holtzman MJ (1995) Stat1 depends on transcriptional synergy with Sp1. J Biol Chem 270: 30264-30267.
39. Lee YW, Kuhn H, Hennig B, Neish AS, Toborek M (2001) IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J Mol Cell Cardiol 33: 83-94.
40. Tanaka T, Kurabayashi M, Aihara Y, Ohyama Y, Nagai R (2000) Inducible expression of manganese superoxide dismutase by Phorbol 12-Myristate 13-Acetate is mediated by Sp1 in endothelial Cells. Arterioscler Thromb Vasc Biol 20: 392-401.
41. Tontonoz P, Nagy L, Alvarez JG, Thomazy, VA, Evans, RM (1998) PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93: 241-252.
42. Marx N, Sukhova G, Murphy C, Libby P, Lutzky J (1998) Macrophages in human atheroma contain PPAR-gamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPAR-gamma) expression and reduction of MMP-9 activity through PPAR-gamma activation in mononuclear phagocytes in vitro. Am J Pathol 153: 17-23.
43. Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, et al. (2001) PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 7: 48-52.
44. Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A (2005) Resistin, an adipokine with potent pro-inflammatory properties. J Immunol 174: 5789-5795.
45. Li B, Adams CC, Workman JL (1994) Nucleosome binding by the constitutive transcription factor Sp1. J Biol Chem 269: 7756-7763.
46. Conn KJ, Rich CB, Jensen DE, Fontanilla MR, Bashir MM, et al. (1996) Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription. J Biol Chem 271: 28853-28860.
47. Kennett SB, Udvadia AJ, Horowitz J (1997) Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription. Nucleic Acids Res 25: 3110-3117.
48. Hata Y, Duh E, Zhang K, Robinson GS, Aiello LP (1998) Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence. J Biol Chem 273: 19294-19303.
49. Hoppe KL, Francone OL (1998) Binding and functional effects of transcription factors Sp1 and Sp3 on the proximal human lecithin:cholesterol acyltransferase promoter. J Lipid Res 39: 969-977.
50. Nielsen SJ, Praestegaard M, Jorgensen HF, Clark BF (1998) Different Sp1 family members differentially affect transcription from the human elongation factor 1 A-1 gene promoter. Biochem J 333: 511-517.
51. Rajakumar RA, Thamotharan S, Menon RK, Devaskar SU (1998) Sp1 and Sp3 regulate transcriptional activity of the facilitative glucose transporter isoform-3 gene in mammalian neuroblasts and trophoblasts. J Biol Chem 273: 27474-27483.
52. 2 dopamine receptor gene. DNA and Cell Biol 17: 471-479.
53. Merchant JL, Du M, Todisco A (1999) Sp1 phosphorylation by Erk 2 stimulates DNA binding. Biochem Biophys Res Comm 254: 454-461.
54. Vines CR, Weigent D A (2000) Identification of SP3 as a negative regulatory transcription factor in the monocyte expression of growth hormone. Endocrinology 141: 938-946.
55. Blake MC, Jambou RC, Swick AG, Kahn JW, Aziz khan JC (1990) Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter. Mol Cell Biol 10: 6632-6641.
56. Smale ST, Schmidt MC, Berk AJ, Baltimore D (1990) Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. Proc Natl Acad SciUSA 87: 4509-4513.
57. Javahery R, Khachi A, Lo K, Zenzie-Gregory B, Smale ST (1994) DNA sequence requirements for transcriptional initiator activity in mammalian cells. Mol Cell Biol 14: 116-127.
58. Kaufmann J, Smale ST (1994) Direct recognition of initiator elements by a component of the transcription factor IID complex. Genes Dev 8: 821-829.
59. Naar AM, Beaurang PA, Zhou S, Abraham S, Solomon W, et al. (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398: 828-832.
60. Pazin MJ, Sheridan PL, Cannon K, Cao Z, Keck JG, et al. (1996) NF-κB mediated chromatin reconguration and transcriptional activation of the HIV-1 enhancer in vitro. Genes Dev 10: 37-49.
61. Mitchell P J, Wang C, Tjian R (1987) Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell 50: 847-861.
62. Sassa Y, Yasuaki H, Lloyd P A, Yukio T, Kimitoshi K, et al. (2004) Bifunctional properties of peroxisome proliferator-activated receptor-1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3. Diabetes 53: 1222-1229.
63. Deng T, Shan S, Li PP, Shen ZF, Lu XP, et al. (2006) Peroxisome proliferatoractivated receptor-a transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1. Endocrinology 147: 875-884.
64. Sugawara A, Takeuchi K, Uruno A, Ikeda Y, Arima S, et al. (2001) Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-λ in vascular smooth muscle cells. Endocrinology 142: 3125-3134.
65. Sugawara A, Uruno A, Kudo M, Ikeda Y, Sato K, et al. (2002) Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-λ via an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem 277: 9676-9683.
66. Chung SS, Choi HH, Cho YM, Lee HK, Park KS (2006) Sp1 mediates repression of the resistin gene by PPAR gamma agonists in 3T3-L1 adipocytes. Biochem Biophys Res Commun 348: 253-258.
67. Jackson SP, MacDonald, JJ, Lees-Miller S, Tjian R (1990) GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63: 155-165.
68. Jackson SP, Tjian R (1988) O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. Cell 55: 125-133.