Polymorphisms of the Resistin Gene and Their Association with Obesity and Resistin Levels in Malaysian Malays

Biochemical Genetics

Volumn 53, Issue 4-6, 2015, Pages 120-131

  Apalasamy, Yamunah Devi ^a   Rampal, Sanjay ^a   Salim, Agus ^b   Moy, Foong Ming ^a   Su, Tin Tin ^a   Majid, Hazreen Abdul ^a   Bulgiba, Awang ^a   Mohamed, Zahurin ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b LA TROBE UNIVERSITY   (Australia)

Author keywords

BMI; Body mass index; Obesity haplotypes; RETN

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RESISTIN; TRIACYLGLYCEROL; RETN PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONCENTRATION (PARAMETERS); DIASTOLIC BLOOD PRESSURE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HIP CIRCUMFERENCE; HUMAN; MAJOR CLINICAL STUDY; MALAY (PEOPLE); METABOLIC PARAMETERS; OBESITY; RETN GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; GENETIC ASSOCIATION STUDY; GENETICS; LIPID METABOLISM; MALAYSIA; METABOLISM; MIDDLE AGED;

GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; LIPID METABOLISM; MALAYSIA; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RESISTIN;

EID: 84929687746     PISSN: 00062928     EISSN: 15734927     Source Type: Journal    
DOI: 10.1007/s10528-015-9678-9     Document Type: Article

References (43)

1. Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M (2010) Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia 53(2):234–246
2. Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, Saruta T (2003) Correlation between serum resistin level and adiposity in obese individuals. Obes Res 11(8):997–1001
3. Azuma K, Oguchi S, Matsubara Y, Mamizuka T, Murata M, Kikuchi H, Watanabe K, Katsukawa F, Yamazaki H, Shimada A, Saruta T (2004) Novel resistin promoter polymorphisms: association with serum resistin level in Japanese obese individuals. Horm Metab Res 36(8):564–570
4. Barnes KM, Miner JL (2009) Role of resistin in insulin sensitivity in rodents and humans. Curr Protein Pept Sci 10(1):96–107
5. Bienertova-Vasku J, Novak J, Zlamal F, Forejt M, Havlenova S, Jackowska A, Tomandl J, Tomandlova M, Splichal Z, Vasku A (2014) The prediction role of indexes of circulating adipokines for common anthropometric and nutritional characteristics of obesity in the obese Central European population. Eat Behav 15(2):244–251
6. Boffetta P, McLerran D, Chen Y, Inoue M, Sinha R, He J, Gupta PC, Tsugane S, Irie F, Tamakoshi A, Gao YT, Shu XO, Wang R, Tsuji I, Kuriyama S, Matsuo K, Satoh H, Chen CJ, Yuan JM, Yoo KY, Ahsan H, Pan WH, Gu D, Pednekar MS, Sasazuki S, Sairenchi T, Yang G, Xiang YB, Nagai M, Tanaka H, Nishino Y, You SL, Koh WP, Park SK, Shen CY, Thornquist M, Kang D, Rolland B, Feng Z, Zheng W, Potter JD (2011) Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium. PLoS ONE 6(6):e19930
7. Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591
8. Cho YM, Youn BS, Chung SS, Kim KW, Lee HK, Yu KY, Park HJ, Shin HD, Park KS (2004) Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans. Diabetologia 47(3):559–565
9. Conneely KN, Silander K, Scott LJ, Mohlke KL, Lazaridis KN, Valle TT, Tuomilehto J, Bergman RN, Watanabe RM, Buchanan TA, Collins FS, Boehnke M (2004) Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. Diabetologia 47(10):1782–1788
10. Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, Zhu Q, Considine RV (2003) Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab 88(11):5452–5455
11. El-Shal AS, Pasha HF, Rashad NM (2013) Association of resistin gene polymorphisms with insulin resistance in Egyptian obese patients. Gene 515(1):233–238
12. Haugen F, Jorgensen A, Drevon CA, Trayhurn P (2001) Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes. FEBS Lett 507(1):105–108
13. Hivert MF, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC (2009) Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. Diabetes 58(3):750–756
14. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, Nelson C, Lowman HB, Wright BD, Skelton NJ, Frantz GD, Tumas DB, Peale FV Jr, Shelton DL, Hebert CC (2000) FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 19(15):4046–4055
15. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, Groop L (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24(4):683–689
16. Kim KH, Lee K, Moon YS, Sul HS (2001) A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276(14):11252–11256
17. Kimbell JL, Koropatnick TA, Grove JS, Huang YH, Chiang FT, Quertermous T, Chen R, Donlon TA, Rodriguez BL, Curb JD (2008) Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure. Diabetes Res Clin Pract 81(2):231–237
18. Kumar S, Gupta V, Srivastava N, Mishra S, Natu-Shankar M, Roy U, Chandra A, Negi MP (2014) Resistin 420C/G gene polymorphism on circulating resistin, metabolic risk factors and insulin resistance in adult women. Immunol Lett 162(2 Pt B):287–291
19. Kusminski CM, McTernan PG, Kumar S (2005) Role of resistin in obesity, insulin resistance and Type II diabetes. Clin Sci (Lond) 109(3):243–256
20. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, Orlova C, Mantzoros CS (2003) Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab 88(10):4848–4856
21. Liu GL, Fu XH, Jiang LH, Ma XC, Yang JY (2006) Serum resistin concentration and insulin resistance in obese children. Zhonghua Er Ke Za Zhi 44(2):114–117
22. McTernan PG, Kusminski CM, Kumar S (2006) Resistin. Curr Opin Lipidol 17(2):170–175
23. Menashe I, Rosenberg PS, Chen BE (2008) PGA: power calculator for case-control genetic association analyses. BMC Genet 9:36
24. Menzaghi C, Coco A, Salvemini L, Thompson R, De Cosmo S, Doria A, Trischitta V (2006) Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians. J Clin Endocrinol Metab 91(7):2792–2795
25. Miyamoto Y, Morisaki H, Kokubo Y, Yamanaka I, Tomoike H, Okayama A, Yoshimasa Y, Morisaki T (2009) Resistin gene variations are associated with the metabolic syndrome in Japanese men. Obes Res Clin Pract 3(2):65–74
26. Norata GD, Ongari M, Garlaschelli K, Raselli S, Grigore L, Catapano AL (2007) Plasma resistin levels correlate with determinants of the metabolic syndrome. Eur J Endocrinol 156(2):279–284
27. Ochi M, Osawa H, Onuma H, Murakami A, Nishimiya T, Shimada F, Kato K, Shimizu I, Shishino K, Murase M, Fujii Y, Ohashi J, Makino H (2003) The absence of evidence for major effects of the frequent SNP +299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes. Diabetes Res Clin Pract 61(3):191–198
28. Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H (2010) A at single nucleotide polymorphism-358 is required for G at −420 to confer the highest plasma resistin in the general Japanese population. PLoS ONE 5(3):e9718
29. O’Rahilly S, Farooqi IS (2006) Genetics of obesity. Philos Trans R Soc Lond B 361(1471):1095–1105
30. Osawa H, Yamada K, Onuma H, Murakami A, Ochi M, Kawata H, Nishimiya T, Niiya T, Shimizu I, Nishida W, Hashiramoto M, Kanatsuka A, Fujii Y, Ohashi J, Makino H (2004) The G/G genotype of a resistin single-nucleotide polymorphism at −420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet 75(4):678–686
31. Pfutzner A, Langenfeld M, Kunt T, Lobig M, Forst T (2003) Evaluation of human resistin assays with serum from patients with type 2 diabetes and different degrees of insulin resistance. Clin Lab 49(11–12):571–576
32. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111(7):932–939
33. Schaffler A, Buchler C, Muller-Ladner U, Herfarth H, Ehling A, Paul G, Scholmerich J, Zietz B (2004) Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus. Horm Metab Res 36(10):702–707
34. Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C (2006) Prevalence of fatty liver in children and adolescents. Pediatrics 118(4):1388–1393
35. Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, Lee IK, Park SD, Kim JB (2003) Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha. Mol Endocrinol 17(8):1522–1533
36. Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15(2):97–98
37. Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, Enders GH, Silberg DG, Wen X, Wu GD, Lazar MA (2001a) A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 98(2):502–506
38. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (2001b) The hormone resistin links obesity to diabetes. Nature 409(6818):307–312
39. Ukkola O, Kunnari A, Kesaniemi YA (2008) Genetic variants at the resistin locus are associated with the plasma resistin concentration and cardiovascular risk factors. Regul Pept 149(1–3):56–59
40. Vendrell J, Broch M, Vilarrasa N, Molina A, Gomez JM, Gutierrez C, Simon I, Soler J, Richart C (2004) Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes Res 12(6):962–971
41. Vozarova de Courten B, Degawa-Yamauchi M, Considine RV, Tataranni PA (2004) High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians. Diabetes 53(5):1279–1284
42. Ye H, Zhang HJ, Xu A, Hoo RL (2013) Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone. PLoS ONE 8(6):e65543
43. Zhang J, Qin Y, Zheng X, Qiu J, Gong L, Mao H, Jia W, Guo J (2002) The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure. Zhonghua Yi Xue Za Zhi 82(23):1609–1612