Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy

Malaria Journal

Volumn 14, Issue 1, 2015, Pages

  Deng, Xiaoyan ^a   Duffy, Simon P ^a   Myrand Lapierre, Marie Eve ^a   Matthews, Kerryn ^a   Santoso, Aline Teresa ^a   Du, Yi Ling ^a   Ryan, Katherine S ^a   Ma, Hongshen ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

Biomarkers; Cell deformability; Drug screening; Malaria; Plasmodium falciparum

Indexed keywords

ADENOSINE TRIPHOSPHATASE ATP4 INHIBITOR; ADENOSINE TRIPHOSPHATASE INHIBITOR; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ DERIVATIVE; ARTESUNATE; ATOVAQUONE; BIOLOGICAL MARKER; BISINDOLE ALKALOID; CHLOROQUINE; CLADONIAMIDE A; DIHYDROARTEMISININ; DIMETHYL SULFOXIDE; INDOLE DERIVATIVE; MEFLOQUINE; NITD 246; PROGUANIL; PYRIMETHAMINE; SJ 733; SPIROINDOLONE; TETRACYCLINE; UNCLASSIFIED DRUG; XENOCLADONIAMIDE D;

ANTIMALARIAL ACTIVITY; ARTICLE; BIOPHYSICS; CONTROLLED STUDY; DIMERIZATION; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; EC50; ERYTHROCYTE; ERYTHROCYTE DEFORMABILITY; HUMAN; HUMAN EXPERIMENT; IC50; INFECTED RED BLOOD CELL; MICROFLUIDICS; NONHUMAN; NORMAL HUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; RAPID TEST; SENSITIVITY ANALYSIS; TROPHOZOITE; CELL SHAPE; CYTOLOGY; DRUG MONITORING; LAB ON A CHIP; PRECLINICAL STUDY; PROCEDURES;

ANTIMALARIALS; BIOMARKERS; BIOPHYSICAL PHENOMENA; CELL SHAPE; DRUG EVALUATION, PRECLINICAL; DRUG MONITORING; ERYTHROCYTES; HUMANS; LAB-ON-A-CHIP DEVICES;

EID: 84946491174     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/s12936-015-0957-z     Document Type: Article

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