Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 1, 2011, Pages 144-154

  Maddahi, Aida ^a   Ansar, Saema ^a,b   Chen, Qingwen ^b   Edvinsson, Lars ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

Author keywords

extracellular signal regulated kinase 1 2 (ERK1 2); matrix metalloproteinase; pro inflammatory cytokines; subarachnoid hemorrhage (SAH); tissue inhibitor of metalloproteinase 1 (TIMP 1)

Indexed keywords

ACTIN; ENZYME INHIBITOR; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAF PROTEIN; SB 386023 B; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN ARTERY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; TREATMENT OUTCOME; WESTERN BLOTTING;

ACTINS; ANIMALS; AUTORADIOGRAPHY; BLOTTING, WESTERN; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; RAF KINASES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE;

EID: 78650891600     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.62     Document Type: Article

References (28)

1. Ansar S, Edvinsson L (2008) Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Stroke 39:185-90
2. Ansar S, Edvinsson L (2009) Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. Laboratory investigation. J Neurosurg 111:978-87
3. Ansar S, Vikman P, Nielsen M, Edvinsson L (2007) Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol 293:H3750-8
4. Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH (2000) Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab 20:1681-9
5. Baker AH, Sica V, Work LM, Williams-Ignarro S, de Nigris F, Lerman LO, Casamassimi A, Lanza A, Schiano C, Rienzo M, Ignarro LJ, Napoli C (2007) Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proc Natl Acad Sci USA 104:3597-602
6. Beg SA, Hansen-Schwartz JA, Vikman PJ, Xu CB, Edvinsson LI (2006) ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat. J Cereb Blood Flow Metab 26:846-56
7. Cahill J, Calvert JW, Zhang JH (2006) Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 26:1341-53
8. Cunningham LA, Wetzel M, Rosenberg GA (2005) Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 50:329-39
9. Delgado TJ, Brismar J, Svendgaard NA (1985) Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries. Stroke 16:595-602
10. Dumont AS, Dumont RJ, Chow MM, Lin CL, Calisaneller T, Ley KF, Kassell NF, Lee KS (2003) Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation. Neurosurgery 53:123-33; discussion 133-135
11. Gallia GL, Tamargo RJ (2006) Leukocyte-endothelial cell interactions in chronic vasospasm after subarachnoid hemorrhage. Neurol Res 28:750-8
12. Gjedde A, Hansen AJ, Siemkowicz E (1980) Rapid simultaneous determination of regional blood flow and blood-brain glucose transfer in brain of rat. Acta Physiol Scand 108:321-30
13. Hansen-Schwartz J, Hoel NL, Zhou M, Xu CB, Svendgaard NA, Edvinsson L (2003) Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries. Neurosurgery 52:1188-94; 1194-1195
14. Henriksson M, Stenman E, Vikman P, Edvinsson L (2007) MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia. Exp Brain Res 178:470-6
15. Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME (1997) Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 17:9157-64
16. Kaminska B (2005) MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta 1754:253-62
17. Mun-Bryce S, Rosenberg GA (1998) Matrix metalloproteinases in cerebrovascular disease. J Cereb Blood Flow Metab 18:1163-72
18. Napoli C (2002) MMP inhibition and the development of cerebrovascular atherosclerosis: the road ahead. Stroke 33:2864-5
19. Pannu H, Kim DH, Guo D, King TM, Van Ginhoven G, Chin T, Chang K, Qi Y, Shete S, Milewicz DM (2006) The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. J Neurosurg 105: 418-23
20. Prunell GF, Mathiesen T, Diemer NH, Svendgaard NA (2003) Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models. Neurosurgery 52:165-75; discussion 175-176
21. Prunell GF, Svendgaard NA, Alkass K, Mathiesen T (2005) Inflammation in the brain after experimental subarachnoid hemorrhage. Neurosurgery 56:1082-92; discussion 1082-1092
22. Rosell A, Ortega-Aznar A, Alvarez-Sabin J, Fernandez-Cadenas I, Ribo M, Molina CA, Lo EH, Montaner J (2006) Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke 37:1399-406
23. Rosenberg GA (2002) Matrix metalloproteinases in neuroinflammation. Glia 39:279-91
24. Sakurada O, Kennedy C, Jehle J, Brown JD, Carbin GL, Sokoloff L (1978) Measurement of local cerebral blood flow with iodo [14C] antipyrine. Am J Physiol 234:H59-66
25. Stenman E, Edvinsson L (2004) Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats. Stroke 35:970-4
26. Tibbs R, Zubkov A, Aoki K, Meguro T, Badr A, Parent A, Zhang J (2000) Effects of mitogen-activated protein kinase inhibitors on cerebral vasospasm in a doublehemorrhage model in dogs. J Neurosurg 93:1041-7
27. Vikman P, Ansar S, Edvinsson L (2007) Transcriptional regulation of inflammatory and extracellular matrixregulating genes in cerebral arteries following experimental subarachnoid hemorrhage in rats. Laboratory investigation. J Neurosurg 107:1015-22
28. Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA (2007) Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab 27:697-709