Choline supplementation restores substrate balance and alleviates complications of Pcyt2 deficiency

Journal of Nutritional Biochemistry

Volumn 26, Issue 11, 2015, Pages 1221-1234

  Schenkel, Laila C ^a   Sivanesan, Sugashan ^a   Zhang, Junzeng ^b   Wuyts, Birgitte ^c   Taylor, Adrian ^a   Verbrugghe, Adronie ^d   Bakovic, Marica ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d UNIVERSITY OF GUELPH   (Canada)

Author keywords

Choline; Ethanolamine; Kennedy pathway; Pcyt2; Phospholipids

Indexed keywords

CHOLINE; FATTY ACID; HOMOCYSTEINE; PHOSPHATIDYLETHANOLAMINE; SPHINGOMYELIN; TRIACYLGLYCEROL; ACYLCARNITINE; CARNITINE; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; RNA POLYMERASE;

ADIPOCYTE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET THERAPY; ENZYME DEFICIENCY; FATTY LIVER; GENE CONTROL; HYPERTRIGLYCERIDEMIA; LIPID OXIDATION; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; OBESITY; PHOSPHOETHANOLAMINE CYTIDYLYLTRANSFERASE 2 DEFICIENCY; SUPPLEMENTATION; SYNTHESIS; TRIACYLGLYCEROL BLOOD LEVEL; TURNOVER TIME; ACYLATION; ADIPOSE TISSUE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DEFICIENCY; DIETARY SUPPLEMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; MUTANT MOUSE STRAIN; WEIGHT GAIN;

ACYLATION; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARNITINE; CHOLINE; DIETARY SUPPLEMENTS; FATTY ACIDS; GENE EXPRESSION REGULATION; LIVER; MICE, MUTANT STRAINS; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLSERINES; RNA NUCLEOTIDYLTRANSFERASES; TRIGLYCERIDES; WEIGHT GAIN;

EID: 84946479403     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.05.014     Document Type: Article

References (43)

1. Zeisel S.H., Blusztajn J.K. Choline and human nutrition. Annu Rev Nutr 1994, 14:269-296.
2. da Costa K.A., Niculescu M.D., Craciunescu C.N., Fischer L.M., Zeisel S.H. Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. Am J Clin Nutr 2006, 84(1):88-94.
3. Zeisel S.H., Da Costa K.A., Franklin P.D., Alexander E.A., Lamont J.T., Sheard N.F., et al. Choline, an essential nutrient for humans. FASEB J 1991, 5(7):2093-2098.
4. Michel V., Singh R.K., Bakovic M. The impact of choline availability on muscle lipid metabolism. Food Funct 2011, 2(1):53-62.
5. Fischer L.M., daCosta K.A., Kwock L., Stewart P.W., Lu T.S., Stabler S.P., et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr 2007, 85(5):1275-1285.
6. Yuan Z., Tie A., Tarnopolsky M., Bakovic M. Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1. Physiol Genomics 2006, 26(1):76-90.
7. Yuan Z., Wagner L., Poloumienko A., Bakovic M. Identification and expression of a mouse muscle-specific CTL1 gene. Gene 2004, 341:305-312.
8. Fullerton M.D., Wagner L., Yuan Z., Bakovic M. Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages. Am J Physiol Cell Physiol 2006, 290(4):C1230-C1238.
9. Michel V., Yuan Z., Ramsubir S., Bakovic M. Choline transport for phospholipid synthesis. Exp Biol Med (Maywood) 2006, 231(5):490-504.
10. Michel V., Bakovic M. The ubiquitous choline transporter SLC44A1. Cent Nerv Syst Agents Med Chem 2012, 12(2):70-81.
11. KENNEDY E.P. Biosynthesis of phospholipides. Fed Proc 1957, 16(3):847-853.
12. KENNEDY E.P., WEISS S.B. The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem 1956, 222(1):193-214.
13. Hermansson M., Hokynar K., Somerharju P. Mechanisms of glycerophospholipid homeostasis in mammalian cells. Prog Lipid Res 2011, 50(3):240-257.
14. Vance J.E., Tasseva G. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim Biophys Acta 2013, 1831(3):543-554.
15. Vance D.E., Ridgway N.D. The methylation of phosphatidylethanolamine. Prog Lipid Res 1988, 27(1):61-79.
16. Vance J.E., Steenbergen R. Metabolism and functions of phosphatidylserine. Prog Lipid Res 2005, 44(4):207-234.
17. Fullerton M.D., Hakimuddin F., Bakovic M. Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2). Mol Cell Biol 2007, 27(9):3327-3336.
18. Fullerton M.D., Bakovic M. Complementation of the metabolic defect in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)-deficient primary hepatocytes. Metabolism 2010, 59(12):1691-1700.
19. Fullerton M.D., Hakimuddin F., Bonen A., Bakovic M. The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase-deficient mice. J Biol Chem 2009, 284(38):25704-25713.
20. Zeisel S.H. Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. Mutat Res 2012, 733(1-2):34-38.
21. Dahlhoff C., Worsch S., Sailer M., Hummel B.A., Fiamoncini J., Uebel K., et al. Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. Mol Metab 2014, 3(5):565-580.
22. BLIGH E.G., DYER W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37(8):911-917.
23. Schenkel L.C., Bakovic M. Palmitic acid and oleic acid differentially regulate choline transporter-like 1 levels and glycerolipid metabolism in skeletal muscle cells. Lipids 2014, 49(8):731-744.
24. Schenkel L.C., Singh R.K., Michel V., Zeisel S.H., da Costa K.A., Johnson A.R., et al. Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts. FASEB J 2014, 29(5):1663-1675.
25. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226(1):497-509.
26. Zytkovicz T.H., Fitzgerald E.F., Marsden D., Larson C.A., Shih V.E., Johnson D.M., et al. Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn Screening Program. Clin Chem 2001, 47(11):1945-1955.
27. Michel V., Bakovic M. The solute carrier 44A1 is a mitochondrial protein and mediates choline transport. FASEB J 2009, (23):2749-2758.
28. Moran-Salvador E., Lopez-Parra M., Garcia-Alonso V., Titos E., Martinez-Clemente M., Gonzalez-Periz A., et al. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J 2011, 25(8):2538-2550.
29. Singh R.K., Fullerton M.D., Vine D., Bakovic M. Mechanism of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase-deficient mice. J Lipid Res 2012, 53(9):1811-1822.
30. Pereira L. The role of a defect in the CDP-ethanolamine pathway in autophagy [dissertation] 2012, University of Guelph.
31. Wang L., Chen L., Tan Y., Wei J., Chang Y., Jin T., et al. Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter. Lipids Health Dis 2013, 12:34.
32. Al Rajabi A., Castro G.S., da Silva R.P., Nelson R.C., Thiesen A., Vannucchi H., et al. Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet. J Nutr 2014, 144(3):252-257.
33. Kersten S., Desvergne B., Wahli W. Roles of PPARs in health and disease. Nature 2000, 405(6785):421-424.
34. Puigserver P. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes (Lond) 2005, 29(Suppl. 1):S5-S9.
35. Koves T.R., Ussher J.R., Noland R.C., Slentz D., Mosedale M., Ilkayeva O., et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008, 7(1):45-56.
36. Vreken P., van Lint A.E., Bootsma A.H., Overmars H., Wanders R.J., van Gennip A.H. Rapid diagnosis of organic acidemias and fatty-acid oxidation defects by quantitative electrospray tandem-MS acyl-carnitine analysis in plasma. Adv Exp Med Biol 1999, 466:327-337.
37. Koves T.R., Li P., An J., Akimoto T., Slentz D., Ilkayeva O., et al. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 2005, 280(39):33588-33598.
38. Soeters M.R., Serlie M.J., Sauerwein H.P., Duran M., Ruiter J.P., Kulik W., et al. Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite. Metabolism 2012, 61(7):966-973.
39. Newgard C.B., An J., Bain J.R., Muehlbauer M.J., Stevens R.D., Lien L.F., et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009, 9(4):311-326.
40. Sampey B.P., Freemerman A.J., Zhang J., Kuan P.F., Galanko J.A., O'Connell T.M., et al. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One 2012, 7(6):e38812.
41. Dumas M.E., Barton R.H., Toye A., Cloarec O., Blancher C., Rothwell A., et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A 2006, 103(33):12511-12516.
42. 1H NMR spectroscopy. J Proteome Res 2013, 12(6):2958-2966.
43. Dawiskiba T., Deja S., Mulak A., Zabek A., Jawien E., Pawelka D., et al. Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases. World J Gastroenterol 2014, 20(1):163-174.