메뉴 건너뛰기




Volumn 59, Issue 12, 2010, Pages 1691-1700

Complementation of the metabolic defect in CTP: Phosphoethanolamine cytidylyltransferase (Pcyt2)-deficient primary hepatocytes

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; COMPLEMENTARY DNA; DIACYLGLYCEROL; ETHANOLAMINE; GLYCEROL; MYC PROTEIN; PHOSPHATIDYLETHANOLAMINE; TRIACYLGLYCEROL;

EID: 78549234648     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.03.022     Document Type: Article
Times cited : (20)

References (37)
  • 1
    • 34347401300 scopus 로고    scopus 로고
    • Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: The role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)
    • Bakovic M., Fullerton M.D., and Michel V. Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) Biochem Cell Biol 85 2007 283 300
    • (2007) Biochem Cell Biol , vol.85 , pp. 283-300
    • Bakovic, M.1    Fullerton, M.D.2    Michel, V.3
  • 2
    • 0002360622 scopus 로고
    • Enzymatic formation and decarboxylation of phosphatidylserine
    • Borkenhagen L.F., Kennedy E.P., and Fielding L. Enzymatic formation and decarboxylation of phosphatidylserine J Biol Chem 236 1961 PC28 PC30
    • (1961) J Biol Chem , vol.236
    • Borkenhagen, L.F.1    Kennedy, E.P.2    Fielding, L.3
  • 3
    • 0022636810 scopus 로고
    • Isolation and characterization of a Chinese hamster ovary cell line requiring ethanolamine or phosphatidylserine for growth and exhibiting defective phosphatidylserine synthase activity
    • Voelker D.R., and Frazier J.L. Isolation and characterization of a Chinese hamster ovary cell line requiring ethanolamine or phosphatidylserine for growth and exhibiting defective phosphatidylserine synthase activity J Biol Chem 261 1986 1002 1008
    • (1986) J Biol Chem , vol.261 , pp. 1002-1008
    • Voelker, D.R.1    Frazier, J.L.2
  • 4
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipids
    • Kennedy E.P., and Weiss S.B. The function of cytidine coenzymes in the biosynthesis of phospholipids J Biol Chem 222 1956 193 214
    • (1956) J Biol Chem , vol.222 , pp. 193-214
    • Kennedy, E.P.1    Weiss, S.B.2
  • 5
    • 0016753096 scopus 로고
    • Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver
    • Sundler R. Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver J Biol Chem 250 1975 8585 8590
    • (1975) J Biol Chem , vol.250 , pp. 8585-8590
    • Sundler, R.1
  • 7
    • 0028279524 scopus 로고
    • Ultrastructural localization of CTP:phosphoethanolamine cytidylyltransferase in rat liver
    • van Hellemond J.J., Slot J.W., and Geelen M.J. Ultrastructural localization of CTP:phosphoethanolamine cytidylyltransferase in rat liver J Biol Chem 269 1994 15415 15418
    • (1994) J Biol Chem , vol.269 , pp. 15415-15418
    • Van Hellemond, J.J.1    Slot, J.W.2    Geelen, M.J.3
  • 8
    • 0028293429 scopus 로고
    • Substrate specificity of CTP: Phosphoethanolamine cytidylyltransferase purified from rat liver
    • Vermeulen P.S., Geelen M.J., and van Golde L.M. Substrate specificity of CTP: phosphoethanolamine cytidylyltransferase purified from rat liver Biochim Biophys Acta 1211 1994 343 349
    • (1994) Biochim Biophys Acta , vol.1211 , pp. 343-349
    • Vermeulen, P.S.1    Geelen, M.J.2    Van Golde, L.M.3
  • 9
    • 0027468258 scopus 로고
    • Immunological characterization, lipid dependence, and subcellular localization of CTP:phosphoethanolamine cytidylyltransferase purified from rat liver. Comparison with CTP:phosphocholine cytidylyltransferase
    • Vermeulen P.S., Tijburg L.B., and Geelen M.J. Immunological characterization, lipid dependence, and subcellular localization of CTP:phosphoethanolamine cytidylyltransferase purified from rat liver. Comparison with CTP:phosphocholine cytidylyltransferase J Biol Chem. 268 1993 7458 7464
    • (1993) J Biol Chem. , vol.268 , pp. 7458-7464
    • Vermeulen, P.S.1    Tijburg, L.B.2    Geelen, M.J.3
  • 10
    • 0029840156 scopus 로고    scopus 로고
    • Isolation and characterization of ECT1 gene encoding CTP: Phosphoethanolamine cytidylyltransferase of Saccharomyces cerevisiae
    • Min-Seok R., Kawamata Y., and Nakamura H. Isolation and characterization of ECT1 gene encoding CTP: phosphoethanolamine cytidylyltransferase of Saccharomyces cerevisiae J Biochem (Tokyo) 120 1996 1040 1047
    • (1996) J Biochem (Tokyo) , vol.120 , pp. 1040-1047
    • Min-Seok, R.1    Kawamata, Y.2    Nakamura, H.3
  • 11
    • 0030975483 scopus 로고    scopus 로고
    • Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
    • Nakashima A., Hosaka K., and Nikawa J. Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant J Biol Chem 272 1997 9567 9572
    • (1997) J Biol Chem , vol.272 , pp. 9567-9572
    • Nakashima, A.1    Hosaka, K.2    Nikawa, J.3
  • 12
    • 0033213987 scopus 로고    scopus 로고
    • Cloning and expression of CTP:phosphoethanolamine cytidylyltransferase cDNA from rat liver
    • Bladergroen B.A., Houweling M., and Geelen M.J. Cloning and expression of CTP:phosphoethanolamine cytidylyltransferase cDNA from rat liver Biochem J 343 Pt 1 1999 107 114
    • (1999) Biochem J , vol.343 , Issue.PART 1 , pp. 107-114
    • Bladergroen, B.A.1    Houweling, M.2    Geelen, M.J.3
  • 13
    • 0347419431 scopus 로고    scopus 로고
    • Genomic organization and differential splicing of the mouse and human Pcyt2 genes
    • Poloumienko A., Cote A., and Quee A.T. Genomic organization and differential splicing of the mouse and human Pcyt2 genes Gene 325 2004 145 155
    • (2004) Gene , vol.325 , pp. 145-155
    • Poloumienko, A.1    Cote, A.2    Quee, A.T.3
  • 14
    • 0001519162 scopus 로고    scopus 로고
    • Identification of functional conserved residues of CTP:glycerol-3- phosphate cytidylyltransferase. Role of histidines in the conserved HXGH in catalysis
    • Park Y.S., Gee P., and Sanker S. Identification of functional conserved residues of CTP:glycerol-3-phosphate cytidylyltransferase. Role of histidines in the conserved HXGH in catalysis J Biol Chem. 272 1997 15161 15166
    • (1997) J Biol Chem. , vol.272 , pp. 15161-15166
    • Park, Y.S.1    Gee, P.2    Sanker, S.3
  • 15
    • 34948859084 scopus 로고    scopus 로고
    • Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties
    • Tie A., and Bakovic M. Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties J Lipid Res 48 2007 2172 2181
    • (2007) J Lipid Res , vol.48 , pp. 2172-2181
    • Tie, A.1    Bakovic, M.2
  • 16
    • 23744473871 scopus 로고    scopus 로고
    • Characterization of transcription factors and cis-acting elements that regulate human CTP: Phosphoethanolamine cytidylyltransferase (Pcyt2)
    • Johnson C.M., Yuan Z., and Bakovic M. Characterization of transcription factors and cis-acting elements that regulate human CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) Biochim Biophys Acta 1735 2005 230 235
    • (2005) Biochim Biophys Acta , vol.1735 , pp. 230-235
    • Johnson, C.M.1    Yuan, Z.2    Bakovic, M.3
  • 17
    • 67649742844 scopus 로고    scopus 로고
    • Stimulation of the human CTP: Phosphoethanolamine cytidylyltransferase gene by early growth response protein 1
    • Zhu L., Johnson C., and Bakovic M. Stimulation of the human CTP: phosphoethanolamine cytidylyltransferase gene by early growth response protein 1 J Lipid Res 49 2008 2197 2211
    • (2008) J Lipid Res , vol.49 , pp. 2197-2211
    • Zhu, L.1    Johnson, C.2    Bakovic, M.3
  • 18
    • 69349097406 scopus 로고    scopus 로고
    • Regulation of the mouse CTP: Phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis
    • Zhu L., Michel V., and Bakovic M. Regulation of the mouse CTP: phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis Gene 447 2009 51 59
    • (2009) Gene , vol.447 , pp. 51-59
    • Zhu, L.1    Michel, V.2    Bakovic, M.3
  • 19
    • 0016761879 scopus 로고
    • Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates
    • Sundler R., and Akesson B. Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates J Biol Chem 250 1975 3359 3367
    • (1975) J Biol Chem , vol.250 , pp. 3359-3367
    • Sundler, R.1    Akesson, B.2
  • 20
    • 0035910413 scopus 로고    scopus 로고
    • Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway
    • Lykidis A., Wang J., and Karim M.A. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway J Biol Chem 276 2001 2174 2179
    • (2001) J Biol Chem , vol.276 , pp. 2174-2179
    • Lykidis, A.1    Wang, J.2    Karim, M.A.3
  • 21
    • 0024546179 scopus 로고
    • Inhibition of phosphatidylethanolamine synthesis by glucagon in isolated rat hepatocytes
    • Tijburg L.B., Houweling M., and Geelen M.J. Inhibition of phosphatidylethanolamine synthesis by glucagon in isolated rat hepatocytes Biochem J 257 1989 645 650
    • (1989) Biochem J , vol.257 , pp. 645-650
    • Tijburg, L.B.1    Houweling, M.2    Geelen, M.J.3
  • 22
    • 70350002081 scopus 로고    scopus 로고
    • The development of a metabolic disease phenotype in CTP: phosphoethanolamine cytidylyltransferase-deficient mice
    • Fullerton M.D., Hakimuddin F., and Bonen A. The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase- deficient mice J Biol Chem 284 2009 25704 25713
    • (2009) J Biol Chem , vol.284 , pp. 25704-25713
    • Fullerton, M.D.1    Hakimuddin, F.2    Bonen, A.3
  • 23
    • 34247608114 scopus 로고    scopus 로고
    • Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2)
    • Fullerton M.D., Hakimuddin F., and Bakovic M. Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2) Mol Cell Biol 27 2007 3327 3336
    • (2007) Mol Cell Biol , vol.27 , pp. 3327-3336
    • Fullerton, M.D.1    Hakimuddin, F.2    Bakovic, M.3
  • 24
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification Can J Biochem Physiol 37 1959 911 917
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 26
    • 3442892340 scopus 로고    scopus 로고
    • Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cells
    • Caviglia J.M., De Gomez Dumm I.N., and Coleman R.A. Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cells J Lipid Res 45 2004 1500 1509
    • (2004) J Lipid Res , vol.45 , pp. 1500-1509
    • Caviglia, J.M.1    De Gomez Dumm, I.N.2    Coleman, R.A.3
  • 27
    • 44449095056 scopus 로고    scopus 로고
    • Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    • Guo Y., Walther T.C., and Rao M. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization Nature 453 2008 657 661
    • (2008) Nature , vol.453 , pp. 657-661
    • Guo, Y.1    Walther, T.C.2    Rao, M.3
  • 28
    • 0031883290 scopus 로고    scopus 로고
    • Neutral lipid storage disease: A genetic disorder with abnormalities in the regulation of phospholipid metabolism
    • Igal R.A., and Coleman R.A. Neutral lipid storage disease: a genetic disorder with abnormalities in the regulation of phospholipid metabolism J Lipid Res 39 1998 31 43
    • (1998) J Lipid Res , vol.39 , pp. 31-43
    • Igal, R.A.1    Coleman, R.A.2
  • 29
    • 43249108174 scopus 로고    scopus 로고
    • Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis
    • Vance D.E. Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis Curr Opin Lipidol 19 2008 229 234
    • (2008) Curr Opin Lipidol , vol.19 , pp. 229-234
    • Vance, D.E.1
  • 30
    • 0034103658 scopus 로고    scopus 로고
    • Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
    • Smith S.J., Cases S., and Jensen D.R. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat Nat Genet 25 2000 87 90
    • (2000) Nat Genet , vol.25 , pp. 87-90
    • Smith, S.J.1    Cases, S.2    Jensen, D.R.3
  • 31
    • 0347993103 scopus 로고    scopus 로고
    • Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts
    • Bagnato C., and Igal R.A. Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts J Biol Chem 278 2003 52203 52211
    • (2003) J Biol Chem , vol.278 , pp. 52203-52211
    • Bagnato, C.1    Igal, R.A.2
  • 32
    • 0036889152 scopus 로고    scopus 로고
    • Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition
    • Hammond L.E., Gallagher P.A., and Wang S. Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition Mol Cell Biol 22 2002 8204 8214
    • (2002) Mol Cell Biol , vol.22 , pp. 8204-8214
    • Hammond, L.E.1    Gallagher, P.A.2    Wang, S.3
  • 33
    • 19744379323 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
    • Dobrzyn A., Dobrzyn P., and Miyazaki M. Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver J Biol Chem 280 2005 23356 23362
    • (2005) J Biol Chem , vol.280 , pp. 23356-23362
    • Dobrzyn, A.1    Dobrzyn, P.2    Miyazaki, M.3
  • 34
    • 34547946930 scopus 로고    scopus 로고
    • Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
    • Choi C.S., Savage D.B., and Kulkarni A. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance J Biol Chem 282 2007 22678 22688
    • (2007) J Biol Chem , vol.282 , pp. 22678-22688
    • Choi, C.S.1    Savage, D.B.2    Kulkarni, A.3
  • 35
    • 68949181550 scopus 로고    scopus 로고
    • Specific role for acyl CoA:diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
    • Villanueva C.J., Monetti M., and Shih M. Specific role for acyl CoA:diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids Hepatology 50 2009 434 442
    • (2009) Hepatology , vol.50 , pp. 434-442
    • Villanueva, C.J.1    Monetti, M.2    Shih, M.3
  • 36
    • 70350442568 scopus 로고    scopus 로고
    • Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis
    • Leonardi R., Frank M.W., and Jackson P.D. Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis J Biol Chem 284 2009 27077 27089
    • (2009) J Biol Chem , vol.284 , pp. 27077-27089
    • Leonardi, R.1    Frank, M.W.2    Jackson, P.D.3
  • 37
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C., Chen Y., and Cline G.W. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle J Biol Chem 277 2002 50230 50236
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.