The solute carrier 44A1 is a mitochondrial protein and mediates choline transport

FASEB Journal

Volumn 23, Issue 8, 2009, Pages 2749-2758

  Michel, Vera ^a   Bakovic, Marica ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

CTL1; Mitochondria; Phosphatidylcholine; SLC44A1

Indexed keywords

CHOLINE; HEMICHOLINIUM 3; MITOCHONDRIAL PROTEIN; CTL1 PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; MESSENGER RNA; ORGANIC CATION TRANSPORTER; PRIMER DNA; RECOMBINANT PROTEIN; SLC44A1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CELL ISOLATION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CENTRIFUGATION; CHOLINE UPTAKE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; LIVER CELL; MICROSOME; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VITAMIN DEFICIENCY; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; IN VITRO STUDY; METABOLISM; MITOCHONDRION; NUCLEOTIDE SEQUENCE; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD; BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; CHOLINE; CHOLINE DEFICIENCY; DNA PRIMERS; FEMALE; HEMICHOLINIUM 3; HUMANS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; ORGANIC CATION TRANSPORT PROTEINS; RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 67649552158     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-121491     Document Type: Article

References (40)

1. Zeisel, S. H. (2000) Choline: an essential nutrient for humans. Nutrition 16, 669-671
2. Zeisel, S. H. (1997) Choline: essential for brain development and function. Adv. Pediatr. 44, 263-295
3. Fisher, M. C., Zeisel, S. H., Mar, M. H., and Sadler, T. W. (2001) Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology 64, 114-122
4. Blusztajn, J. K., and Wurtman, R. J. (1983) Choline and cholinergic neurons. Science 221, 614-620
5. Deves, R., and Krupka, R. M. (1979) The binding and translocation steps in transport as related to substrate structure. A study of the choline carrier of erythrocytes. Biochim. Biophys. Acta 557, 469-485 (Pubitemid 10198016)
6. Grassl, S. M. (1994) Choline transport in human placental brush-border membrane vesicles. Biochim. Biophys. Acta 1194, 203-213 (Pubitemid 24270392)
7. Simon, J. R., Atweh, S., and Kuhar, M. J. (1976) Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine. J. Neurochem. 26, 909-922
8. Yuan, Z., Wagner, L., Poloumienko, A., and Bakovic, M. (2004) Identification and expression of a mouse muscle-specific CTL1 gene. Gene 341, 305-312 (Pubitemid 39335905)
9. O'Regan, S., Traiffort, E., Ruat, M., Cha, N., Compaore, D., and Meunier, F. M. (2000) An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter- like proteins. Proc. Natl. Acad. Sci. U. S. A. 97, 1835-1840 (Pubitemid 30118529)
10. Wille, S., Szekeres, A., Majdic, O., Prager, E., Staffler, G., Stockl, J., Kunthalert, D., Prieschl, E. E., Baumruker, T., Burtscher, H., Zlabinger, G. J., Knapp, W., and Stockinger, H. (2001) Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells. J. Immunol. 167, 5795-5804 (Pubitemid 33062771)
11. Michel, V., Yuan, Z., Ramsubir, S., and Bakovic, M. (2006) Choline transport for phospholipid synthesis. Exp. Biol. Med. (Maywood) 231, 490-504
12. Mellott, T. J., Kowall, N. W., Lopez-Coviella, I., and Blusztajn, J. K. (2007) Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. Brain Res. 1151, 1-11 (Pubitemid 46709862)
13. Zeisel, S. H. (2005) Choline, homocysteine, and pregnancy. Am. J. Clin. Nutr. 82, 719-720
14. Zeisel, S. H., Da Costa, K. A., Franklin, P. D., Alexander, E. A., Lamont, J. T., Sheard, N. F., and Beiser, A. (1991) Choline, an essential nutrient for humans. FASEB J. 5, 2093-2098
15. Traiffort, E., Ruat, M., O'Regan, S., and Meunier, F. M. (2005) Molecular characterization of the family of choline transporter-like proteins and their splice variants. J. Neurochem. 92, 1116-1125 (Pubitemid 40344302)
16. +-independent choline transporter in rat astrocytes. J. Neurochem. 94, 1427-1437
17. +-independent choline transport in primary cultures of neurons from mouse cerebral cortex. Neurosci. Lett. 393, 216-221
18. Fullerton, M. D., Wagner, L., Yuan, Z., and Bakovic, M. (2006) Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages. Am. J. Physiol. Cell. Physiol. 290, C1230-C1238
19. Spector, D. L., Goldman, R. D., and Leinwand, L. A. (1998) Cells: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Plainview, NY, USA
20. Hovius, R., Lambrechts, H., Nicolay, K., and de Kruijff, B. (1990) Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane. Biochim. Biophys. Acta 1021, 217-226 (Pubitemid 20037572)
21. Kaplan, C. P., Porter, R. K., and Brand, M. D. (1993) The choline transporter is the major site of control of choline oxidation in isolated rat liver mitochondria. FEBS Lett. 321, 24-26 (Pubitemid 23112083)
22. Zhu, L. J., and Altmann, S. W. (2005) mRNA and 18S-RNA coapplication-reverse transcription for quantitative gene expression analysis. Anal. Biochem. 345, 102-109 (Pubitemid 41558200)
23. Porter, R. K., Scott, J. M., and Brand, M. D. (1992) Choline transport into rat liver mitochondria. Characterization and kinetics of a specific transporter. J. Biol. Chem. 267, 14637-14646
24. Emanuelsson, O., Nielsen, H., Brunak, S., and von Heijne, G. (2000) Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. J. Mol. Biol. 300, 1005-1016 (Pubitemid 30708188)
25. Pfanner, N., and Geissler, A. (2001) Versatility of the mitochondrial protein import machinery. Nat. Rev. Mol. Cell. Biol. 2, 339-349 (Pubitemid 33674046)
26. Diekert, K., Kispal, G., Guiard, B., and Lill, R. (1999) An internal targeting signal directing proteins into the mitochondrial intermembrane space. Proc. Natl. Acad. Sci. U. S. A. 96, 11752-11757 (Pubitemid 29502804)
27. Arnold, I., Folsch, H., Neupert, W., and Stuart, R. A. (1998) Two distinct and independent mitochondrial targeting signals function in the sorting of an inner membrane protein, cytochrome c1. J. Biol. Chem. 273, 1469-1476 (Pubitemid 28133668)
28. Streumer-Svobodova, Z., and Drahota, Z. (1977) The development of oxidative enzymes in rat liver mitochondria. Physiol. Bohemoslov. 26, 525-534 (Pubitemid 8285231)
29. Porter, R. K., Scott, J. M., and Brand, M. D. (1993) Characterization of betaine efflux from rat liver mitochondria. Biochim. Biophys. Acta 1141, 269-274 (Pubitemid 23070184)
30. Kharbanda, K. K., Mailliard, M. E., Baldwin, C. R., Beckenhauer, H. C., Sorrell, M. F., and Tuma, D. J. (2007) Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J. Hepatol. 46, 314-321
31. Haubrich, D. R., and Gerber, N. H. (1981) Choline dehydrogenase. Assay, properties and inhibitors. Biochem. Pharmacol. 30, 2993-3000
32. McMurray, W. C. (1986) Origins of the phospholipids in animal mitochondria. Biochem. Cell Biol. 64, 1115-1124
33. Voelker, D. R. (2004) Lipid synthesis and transport in mitochondrial biogenesis. In Topics in Current Genetics, Vol.8: Mitochondrial Function and Biogenesis pp. 267-291, Springer Berlin/Heidelberg
34. Jin, J. K., Kim, N. H., Lee, Y. J., Kim, Y. S., Choi, E. K., Kozlowski, P. B., Park, M. H., Kim, H. S., and Min, D. S. (2006) Phospholipase D1 is up-regulated in the mitochondrial fraction from the brains of Alzheimer's disease patients. Neurosci. Lett. 407, 263-267
35. Madesh, M., and Balasubramanian, K. A. (1998) Cyclosporin A inhibits oxidant and calcium stimulated phospholipase D activity in the rat intestinal mitochondria. Biochim. Biophys. Acta 1389, 206-212 (Pubitemid 28097320)
36. Birbes, H., El Bawab, S., Hannun, Y. A., and Obeid, L. M. (2001) Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 15, 2669-2679 (Pubitemid 33131093)
37. Stone, S. J., and Vance, J. E. (2000) Phosphatidylserine synthase- 1 and -2 are localized to mitochondria-associated membranes. J. Biol. Chem. 275, 34534-34540
38. Hostetler, K. Y., Zenner, B. D., and Morris, H. P. (1979) Phospholipid content of mitochondrial and microsomal membranes from Morris hepatomas of varying growth rates. Cancer Res. 39, 2978-2983
39. Birbes, H., El Bawab, S., Obeid, L. M., and Hannun, Y. A. (2002) Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv. Enzyme Regul. 42, 113-129 (Pubitemid 35033533)
40. Wang, T., Li, J., Chen, F., Zhao, Y., He, X., Wan, D., and Gu, J. (2007) Choline transporters in human lung adenocarcinoma: expression and functional implications. Acta Biochim. Biophys. Sin. (Shanghai) 39, 668-674 (Pubitemid 47437943)