-
1
-
-
2942537697
-
Effi cacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
-
Edwards JC, Szczepanski L, Szechinski J et al (2004) Effi cacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350:2572-2581
-
(2004)
N Engl J Med
, vol.350
, pp. 2572-2581
-
-
Edwards, J.C.1
Szczepanski, L.2
Szechinski, J.3
-
2
-
-
77954651554
-
Rituximab versus cyclophosphamide for ANCA-associated vasculitis
-
Stone JH, Merkel PA, Spiera R et al (2010) Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med 363:221-232
-
(2010)
N Engl J Med
, vol.363
, pp. 221-232
-
-
Stone, J.H.1
Merkel, P.A.2
Spiera, R.3
-
3
-
-
76649115305
-
A perspective on B-cell-targeting therapy for SLE
-
Looney RJ, Anolik J, Sanz I (2010) A perspective on B-cell-targeting therapy for SLE. Mod Rheumatol 20:1-10
-
(2010)
Mod Rheumatol
, vol.20
, pp. 1-10
-
-
Looney, R.J.1
Anolik, J.2
Sanz, I.3
-
4
-
-
4043179907
-
B cell depletion as a novel treatment for systemic lupus erythematosus: A phase I/II dose-escalation trial of rituximab
-
Looney RJ, Anolik JH, Campbell D et al (2004) B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab. Arthritis Rheum 50:2580-2589
-
(2004)
Arthritis Rheum
, vol.50
, pp. 2580-2589
-
-
Looney, R.J.1
Anolik, J.H.2
Campbell, D.3
-
5
-
-
84871861496
-
Two-year results of an open pilot study of a 2-treatment course with rituximab in patients with early systemic sclerosis with diffuse skin involvement
-
Smith V, Piette Y, van Praet JT et al (2013) Two-year results of an open pilot study of a 2-treatment course with rituximab in patients with early systemic sclerosis with diffuse skin involvement. J Rheumatol 40:52-57
-
(2013)
J Rheumatol
, vol.40
, pp. 52-57
-
-
Smith, V.1
Piette, Y.2
Van Praet, J.T.3
-
6
-
-
77950538947
-
Effectiveness of rituximab treatment in primary Sjogren’s syndrome: A randomized, doubleblind, placebo-controlled trial
-
Meijer JM, Meiners PM, Vissink A et al (2010) Effectiveness of rituximab treatment in primary Sjogren’s syndrome: a randomized, doubleblind, placebo-controlled trial. Arthritis Rheum 62:960-968
-
(2010)
Arthritis Rheum
, vol.62
, pp. 960-968
-
-
Meijer, J.M.1
Meiners, P.M.2
Vissink, A.3
-
7
-
-
39049142995
-
B-cell depletion with rituximab in relapsingremitting multiple sclerosis
-
Hauser SL, Waubant E, Arnold DL et al (2008) B-cell depletion with rituximab in relapsingremitting multiple sclerosis. N Engl J Med 358:676-688
-
(2008)
N Engl J Med
, vol.358
, pp. 676-688
-
-
Hauser, S.L.1
Waubant, E.2
Arnold, D.L.3
-
8
-
-
84875873134
-
B-cell targeted therapeutics in clinical development
-
Bluml S, McKeever K, Ettinger R, Smolen J, Herbst R (2013) B-cell targeted therapeutics in clinical development. Arthritis Res Ther 15(Suppl 1):S4
-
(2013)
Arthritis Res Ther
, vol.15
, pp. 4
-
-
Bluml, S.1
McKeever, K.2
Ettinger, R.3
Smolen, J.4
Herbst, R.5
-
9
-
-
77949297173
-
Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: Clinical features and pathogenesis
-
Tan CS, Koralnik IJ (2010) Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol 9:425-437
-
(2010)
Lancet Neurol
, vol.9
, pp. 425-437
-
-
Tan, C.S.1
Koralnik, I.J.2
-
10
-
-
67649368710
-
Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders
-
Castillo J, Milani C, Mendez-Allwood D (2009) Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders. Expert Opin Investig Drugs 18:491-500
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 491-500
-
-
Castillo, J.1
Milani, C.2
Mendez-Allwood, D.3
-
11
-
-
84860390375
-
Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: A randomised, double-blind, placebocontrolled clinical trial
-
Taylor PC, Quattrocchi E, Mallett S, Kurrasch R, Petersen J, Chang DJ (2011) Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebocontrolled clinical trial. Ann Rheum Dis 70:2119-2125
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 2119-2125
-
-
Taylor, P.C.1
Quattrocchi, E.2
Mallett, S.3
Kurrasch, R.4
Petersen, J.5
Chang, D.J.6
-
12
-
-
77955386129
-
Ofatumumab, a human anti-CD20 monoclonal antibody, for treatment of rheumatoid arthritis with an inadequate response to one or more disease-modifying antirheumatic drugs: Results of a randomized, double-blind, placebo-controlled, phase I/II study
-
Ostergaard M, Baslund B, Rigby W et al (2010) Ofatumumab, a human anti-CD20 monoclonal antibody, for treatment of rheumatoid arthritis with an inadequate response to one or more disease-modifying antirheumatic drugs: results of a randomized, double-blind, placebo-controlled, phase I/II study. Arthritis Rheum 62:2227-2238
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2227-2238
-
-
Ostergaard, M.1
Baslund, B.2
Rigby, W.3
-
13
-
-
84895734917
-
Safety and effi cacy of ofatumumab in relapsingremitting multiple sclerosis: A phase 2 study
-
Sorensen PS, Lisby S, Grove R et al (2014) Safety and effi cacy of ofatumumab in relapsingremitting multiple sclerosis: a phase 2 study. Neurology 82:573-581
-
(2014)
Neurology
, vol.82
, pp. 573-581
-
-
Sorensen, P.S.1
Lisby, S.2
Grove, R.3
-
14
-
-
67650345281
-
Ocrelizumab: A step forward in the evolution of B-cell therapy
-
Kausar F, Mustafa K, Sweis G et al (2009) Ocrelizumab: a step forward in the evolution of B-cell therapy. Expert Opin Biol Ther 9:889-895
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 889-895
-
-
Kausar, F.1
Mustafa, K.2
Sweis, G.3
-
15
-
-
84856388514
-
Safety and effi cacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a fortyeight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial
-
Rigby W, Tony HP, Oelke K et al (2012) Safety and effi cacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a fortyeight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum 64:350-359
-
(2012)
Arthritis Rheum
, vol.64
, pp. 350-359
-
-
Rigby, W.1
Tony, H.P.2
Oelke, K.3
-
16
-
-
84863012323
-
Safety and effi cacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial
-
Tak PP, Mease PJ, Genovese MC et al (2012) Safety and effi cacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum 64:360-370
-
(2012)
Arthritis Rheum
, vol.64
, pp. 360-370
-
-
Tak, P.P.1
Mease, P.J.2
Genovese, M.C.3
-
17
-
-
84883257895
-
Effi cacy and safety of ocrelizumab in active proliferative lupus nephritis: Results from a randomized, double-blind, phase III study
-
Mysler EF, Spindler AJ, Guzman R et al (2013) Effi cacy and safety of ocrelizumab in active proliferative lupus nephritis: results from a randomized, double-blind, phase III study. Arthritis Rheum 65:2368-2379
-
(2013)
Arthritis Rheum
, vol.65
, pp. 2368-2379
-
-
Mysler, E.F.1
Spindler, A.J.2
Guzman, R.3
-
18
-
-
81555202418
-
Ocrelizumab in relapsing-remitting multiple sclerosis: A phase 2, randomised, placebo-controlled, multicentre trial
-
Kappos L, Li D, Calabresi PA et al (2011) Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet 378:1779-1787
-
(2011)
Lancet
, vol.378
, pp. 1779-1787
-
-
Kappos, L.1
Li, D.2
Calabresi, P.A.3
-
19
-
-
84881662563
-
Low-dose anti-CD20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: A phase I study
-
Liebman HA, Saleh MN, Bussel JB et al (2013) Low-dose anti-CD20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: a phase I study. Br J Haematol 162:693-701
-
(2013)
Br J Haematol
, vol.162
, pp. 693-701
-
-
Liebman, H.A.1
Saleh, M.N.2
Bussel, J.B.3
-
20
-
-
77951829072
-
Veltuzumab (Humanized anti-CD20 monoclonal antibody): Characterization, current clinical results, and future prospects
-
Goldenberg DM, Morschhauser F, Wegener WA (2010) Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects. Leuk Lymphoma 51:747-755
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 747-755
-
-
Goldenberg, D.M.1
Morschhauser, F.2
Wegener, W.A.3
-
21
-
-
70349973753
-
CD19: A promising B cell target for rheumatoid arthritis
-
Tedder TF (2009) CD19: a promising B cell target for rheumatoid arthritis. Nat Rev Rheumatol 5:572-577
-
(2009)
Nat Rev Rheumatol
, vol.5
, pp. 572-577
-
-
Tedder, T.F.1
-
22
-
-
27244432745
-
Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease
-
Yazawa N, Hamaguchi Y, Poe JC, Tedder TF (2005) Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proc Natl Acad Sci U S A 102: 15178-15183
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 15178-15183
-
-
Yazawa, N.1
Hamaguchi, Y.2
Poe, J.C.3
Tedder, T.F.4
-
23
-
-
77957244161
-
B-cell depletion in vitro and in vivo with anafucosylated anti-CD19 antibody
-
Herbst R, Wang Y, Gallagher S et al (2010) B-cell depletion in vitro and in vivo with anafucosylated anti-CD19 antibody. J Pharmacol Exp Ther 335:213-222
-
(2010)
J Pharmacol Exp Ther
, vol.335
, pp. 213-222
-
-
Herbst, R.1
Wang, Y.2
Gallagher, S.3
-
24
-
-
84874592146
-
Treating multiple sclerosis with monoclonal antibodies: A 2013 update
-
Deiss A, Brecht I, Haarmann A, Buttmann M (2013) Treating multiple sclerosis with monoclonal antibodies: a 2013 update. Expert Rev Neurother 13:313-335
-
(2013)
Expert Rev Neurother
, vol.13
, pp. 313-335
-
-
Deiss, A.1
Brecht, I.2
Haarmann, A.3
Buttmann, M.4
-
26
-
-
26644450721
-
CD22: A multifunctional receptor that regulates B lymphocyte survival and signal transduction
-
Tedder TF, Poe JC, Haas KM (2005) CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol 88:1-50
-
(2005)
Adv Immunol
, vol.88
, pp. 1-50
-
-
Tedder, T.F.1
Poe, J.C.2
Haas, K.M.3
-
27
-
-
33748778482
-
Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab
-
Carnahan J, Stein R, Qu Z et al (2007) Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab. Mol Immunol 44: 1331-1341
-
(2007)
Mol Immunol
, vol.44
, pp. 1331-1341
-
-
Carnahan, J.1
Stein, R.2
Qu, Z.3
-
28
-
-
70350591584
-
Epratuzumab (Humanised anti-CD22 antibody) in primary Sjogren’s syndrome: An open-label phase I/II study
-
Steinfeld SD, Tant L, Burmester GR et al (2006) Epratuzumab (humanised anti-CD22 antibody) in primary Sjogren’s syndrome: an open-label phase I/II study. Arthritis Res Ther 8:R129
-
(2006)
Arthritis Res Ther
, vol.8
, pp. 129
-
-
Steinfeld, S.D.1
Tant, L.2
Burmester, G.R.3
-
29
-
-
84889657510
-
Effi cacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: Results from EMBLEM, a phase IIb, randomised, double-blind, placebocontrolled, multicentre study
-
Wallace DJ, Kalunian K, Petri MA et al (2014) Effi cacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebocontrolled, multicentre study. Ann Rheum Dis 73:183-190
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 183-190
-
-
Wallace, D.J.1
Kalunian, K.2
Petri, M.A.3
-
30
-
-
84879502096
-
Effi cacy and safety of epratuzumab in patients with moderate/severe fl aring systemic lupus erythematosus: Results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up
-
Wallace DJ, Gordon C, Strand V et al (2013) Effi cacy and safety of epratuzumab in patients with moderate/severe fl aring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up. Rheumatology (Oxford) 52:1313-1322
-
(2013)
Rheumatology (Oxford)
, vol.52
, pp. 1313-1322
-
-
Wallace, D.J.1
Gordon, C.2
Strand, V.3
-
31
-
-
85047690330
-
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
-
Avery DT, Kalled SL, Ellyard JI et al (2003) BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest 112:286-297
-
(2003)
J Clin Invest
, vol.112
, pp. 286-297
-
-
Avery, D.T.1
Kalled, S.L.2
Ellyard, J.I.3
-
32
-
-
0242495115
-
Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator
-
Baker KP, Edwards BM, Main SH et al (2003) Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arthritis Rheum 48:3253-3265
-
(2003)
Arthritis Rheum
, vol.48
, pp. 3253-3265
-
-
Baker, K.P.1
Edwards, B.M.2
Main, S.H.3
-
33
-
-
79952070370
-
Effi cacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
-
Navarra SV, Guzman RM, Gallacher AE et al (2011) Effi cacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 377:721-731
-
(2011)
Lancet
, vol.377
, pp. 721-731
-
-
Navarra, S.V.1
Guzman, R.M.2
Gallacher, A.E.3
-
34
-
-
84876889502
-
Effi cacy and safety of belimumab in patients with rheumatoid arthritis: A phase II, randomized, double-blind, placebo-controlled, dose-ranging Study
-
Stohl W, Merrill JT, McKay JD et al (2013) Effi cacy and safety of belimumab in patients with rheumatoid arthritis: a phase II, randomized, double-blind, placebo-controlled, dose-ranging Study. J Rheumatol 40:579-589
-
(2013)
J Rheumatol
, vol.40
, pp. 579-589
-
-
Stohl, W.1
Merrill, J.T.2
McKay, J.D.3
-
35
-
-
84881247286
-
The BAFF/ APRIL system: Emerging functions beyond B cell biology and autoimmunity
-
Vincent FB, Saulep-Easton D, Figgett WA, Fairfax KA, Mackay F (2013) The BAFF/ APRIL system: emerging functions beyond B cell biology and autoimmunity. Cytokine Growth Factor Rev 24:203-215
-
(2013)
Cytokine Growth Factor Rev
, vol.24
, pp. 203-215
-
-
Vincent, F.B.1
Saulep-Easton, D.2
Figgett, W.A.3
Fairfax, K.A.4
Mackay, F.5
-
36
-
-
78649835509
-
Targeting BAFF in autoimmunity
-
Davidson A (2010) Targeting BAFF in autoimmunity. Curr Opin Immunol 22:732-739
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 732-739
-
-
Davidson, A.1
-
37
-
-
84881480714
-
A phase 2 dose-ranging study of subcutaneous tabalumab for the treatment of patients with active rheumatoid arthritis and an inadequate response to methotrexate
-
Genovese MC, Lee E, Satterwhite J et al (2013) A phase 2 dose-ranging study of subcutaneous tabalumab for the treatment of patients with active rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis 72:1453-1460
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 1453-1460
-
-
Genovese, M.C.1
Lee, E.2
Satterwhite, J.3
-
38
-
-
84896338154
-
Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus
-
Stohl W (2014) Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus. Expert Opin Ther Targets 18: 473-489
-
(2014)
Expert Opin Ther Targets
, vol.18
, pp. 473-489
-
-
Stohl, W.1
-
39
-
-
83455186144
-
Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis
-
Gensicke H, Leppert D, Yaldizli O et al (2012) Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis. CNS Drugs 26:11-37
-
(2012)
CNS Drugs
, vol.26
, pp. 11-37
-
-
Gensicke, H.1
Leppert, D.2
Yaldizli, O.3
-
40
-
-
54949118810
-
Atacicept, a homodimeric fusion protein for the potential treatment of diseases triggered by plasma cells
-
Gatto B (2008) Atacicept, a homodimeric fusion protein for the potential treatment of diseases triggered by plasma cells. Curr Opin Investig Drugs 9:1216-1227
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 1216-1227
-
-
Gatto, B.1
-
41
-
-
18844447818
-
The role of APRIL and BAFF in lymphocyte activation
-
Schneider P (2005) The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol 17:282-289
-
(2005)
Curr Opin Immunol
, vol.17
, pp. 282-289
-
-
Schneider, P.1
-
42
-
-
37149032474
-
Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial
-
Dall’Era M, Chakravarty E, Wallace D et al (2007) Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum 56:4142-4150
-
(2007)
Arthritis Rheum
, vol.56
, pp. 4142-4150
-
-
Dall’Era, M.1
Chakravarty, E.2
Wallace, D.3
-
43
-
-
79959856423
-
Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial
-
van Vollenhoven RF, Kinnman N, Vincent E, Wax S, Bathon J (2011) Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial. Arthritis Rheum 63:1782-1792
-
(2011)
. Arthritis Rheum
, vol.63
, pp. 1782-1792
-
-
Van Vollenhoven, R.F.1
Kinnman, N.2
Vincent, E.3
Wax, S.4
Bathon, J.5
-
44
-
-
79959832697
-
Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II, randomized, placebo-controlled, dose-fi nding trial
-
Genovese MC, Kinnman N, de La BG, Pena RC, Tak PP (2011) Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: results of a phase II, randomized, placebo-controlled, dose-fi nding trial. Arthritis Rheum 63:1793-1803
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1793-1803
-
-
Genovese, M.C.1
Kinnman, N.2
De La, B.G.3
Pena, R.C.4
Tak, P.P.5
-
45
-
-
84896070550
-
Atacicept in multiple sclerosis (ATAMS): A randomised, placebo-controlled, double-blind, phase 2 trial
-
Kappos L, Hartung HP, Freedman MS et al (2014) Atacicept in multiple sclerosis (ATAMS): a randomised, placebo-controlled, double-blind, phase 2 trial. Lancet Neurol 13:353-363
-
(2014)
Lancet Neurol
, vol.13
, pp. 353-363
-
-
Kappos, L.1
Hartung, H.P.2
Freedman, M.S.3
-
46
-
-
84880133587
-
The TNF family member APRIL dampens collagen-induced arthritis
-
Fernandez L, Salinas GF, Rocha C et al (2013) The TNF family member APRIL dampens collagen-induced arthritis. Ann Rheum Dis 72:1367-1374
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 1367-1374
-
-
Fernandez, L.1
Salinas, G.F.2
Rocha, C.3
-
47
-
-
84883199752
-
Mitogen-activated protein kinases in innate immunity
-
Arthur JS, Ley SC (2013) Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 13:679-692
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 679-692
-
-
Arthur, J.S.1
Ley, S.C.2
-
48
-
-
75749092187
-
) “Go upstream, young man”: Lessons learned from the p38 saga
-
Hammaker D, Firestein GS (2010) “Go upstream, young man”: lessons learned from the p38 saga. Ann Rheum Dis 69(Suppl 1):i77-i82
-
(2010)
Ann Rheum Dis 69(Suppl
, vol.1
, pp. 77-82
-
-
Hammaker, D.1
Firestein, G.S.2
-
49
-
-
0036142395
-
Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn’s disease
-
Hommes D, van den Blink B, Plasse T et al (2002) Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn’s disease. Gastroenterology 122:7-14
-
(2002)
Gastroenterology
, vol.122
, pp. 7-14
-
-
Hommes, D.1
Van Den Blink, B.2
Plasse, T.3
-
50
-
-
77953703822
-
A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn’s disease
-
Dotan I, Rachmilewitz D, Schreiber S et al (2010) A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn’s disease. Gut 59:760-766
-
(2010)
Gut
, vol.59
, pp. 760-766
-
-
Dotan, I.1
Rachmilewitz, D.2
Schreiber, S.3
-
51
-
-
35348935662
-
C-Jun N-terminal kinases as potential therapeutic targets
-
Salh B (2007) c-Jun N-terminal kinases as potential therapeutic targets. Expert Opin Ther Targets 11:1339-1353
-
(2007)
Expert Opin Ther Targets
, vol.11
, pp. 1339-1353
-
-
Salh, B.1
-
52
-
-
84871022799
-
C-Jun N-terminal kinase in infl ammation and rheumatic diseases
-
Guma M, Firestein GS (2012) c-Jun N-terminal kinase in infl ammation and rheumatic diseases. Open Rheumatol J 6:220-231
-
(2012)
Open Rheumatol J
, vol.6
, pp. 220-231
-
-
Guma, M.1
Firestein, G.S.2
-
53
-
-
0034931503
-
C-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in infl ammatory arthritis
-
Han Z, Boyle DL, Chang L et al (2001) c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in infl ammatory arthritis. J Clin Invest 108:73-81
-
(2001)
J Clin Invest
, vol.108
, pp. 73-81
-
-
Han, Z.1
Boyle, D.L.2
Chang, L.3
-
54
-
-
79651473582
-
NF-kappaB in immunobiology
-
Hayden MS, Ghosh S (2011) NF-kappaB in immunobiology. Cell Res 21:223-244
-
(2011)
Cell Res
, vol.21
, pp. 223-244
-
-
Hayden, M.S.1
Ghosh, S.2
-
55
-
-
67650724069
-
Regulation and function of NF-kappaB transcription factors in the immune system
-
Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27:693-733
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
56
-
-
0034746919
-
NF-kappaB: A key role in infl ammatory diseases
-
Tak PP, Firestein GS (2001) NF-kappaB: a key role in infl ammatory diseases. J Clin Invest 107:7-11
-
(2001)
J Clin Invest
, vol.107
, pp. 7-11
-
-
Tak, P.P.1
Firestein, G.S.2
-
57
-
-
0034892866
-
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial infl ammation
-
Tak PP, Gerlag DM, Aupperle KR et al (2001) Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial infl ammation. Arthritis Rheum 44:1897-1907
-
(2001)
Arthritis Rheum
, vol.44
, pp. 1897-1907
-
-
Tak, P.P.1
Gerlag, D.M.2
Aupperle, K.R.3
-
58
-
-
70350545937
-
Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial infl ammation
-
Tas SW, Vervoordeldonk MJ, Hajji N, May MJ, Ghosh S, Tak PP (2006) Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial infl ammation. Arthritis Res Ther 8:R86
-
(2006)
Arthritis Res Ther
, vol.8
, pp. 86
-
-
Tas, S.W.1
Vervoordeldonk, M.J.2
Hajji, N.3
May, M.J.4
Ghosh, S.5
Tak, P.P.6
-
59
-
-
81855199748
-
Nuclear factor-kappa B inhibitors; a patent review (2006-2010)
-
Kwak JH, Jung JK, Lee H (2011) Nuclear factor-kappa B inhibitors; a patent review (2006-2010). Expert Opin Ther Pat 21: 1897-1910
-
(2011)
Expert Opin Ther Pat
, vol.21
, pp. 1897-1910
-
-
Kwak, J.H.1
Jung, J.K.2
Lee, H.3
-
60
-
-
84885338213
-
NF-kappaB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-kappaB in immune-mediated diseases
-
Sehnert B, Burkhardt H, Wessels JT et al (2013) NF-kappaB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-kappaB in immune-mediated diseases. Proc Natl Acad Sci U S A 110: 16556-16561
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16556-16561
-
-
Sehnert, B.1
Burkhardt, H.2
Wessels, J.T.3
-
61
-
-
84858735072
-
The noncanonical NF-kappaB pathway
-
Sun SC (2012) The noncanonical NF-kappaB pathway. Immunol Rev 246:125-140
-
(2012)
Immunol Rev
, vol.246
, pp. 125-140
-
-
Sun, S.C.1
-
62
-
-
85027944808
-
NF-kappaB inducing kinase is a key regulator of infl ammation-induced and tumorassociated angiogenesis
-
Noort AR, van Zoest KP, Weijers EM et al (2014) NF-kappaB inducing kinase is a key regulator of infl ammation-induced and tumorassociated angiogenesis. J Pathol 234:375
-
(2014)
J Pathol
, vol.234
, pp. 375
-
-
Noort, A.R.1
Van Zoest, K.P.2
Weijers, E.M.3
-
63
-
-
84873713406
-
Inhibiting NF-kappaB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structureactivity relationship, and co-crystal structures
-
Li K, McGee LR, Fisher B et al (2013) Inhibiting NF-kappaB-inducing kinase (NIK): discovery, structure-based design, synthesis, structureactivity relationship, and co-crystal structures. Bioorg Med Chem Lett 23:1238-1244
-
(2013)
Bioorg Med Chem Lett
, vol.23
, pp. 1238-1244
-
-
Li, K.1
McGee, L.R.2
Fisher, B.3
-
64
-
-
0242468041
-
Regulation of JAKSTAT signalling in the immune system
-
Shuai K, Liu B (2003) Regulation of JAKSTAT signalling in the immune system. Nat Rev Immunol 3:900-911
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 900-911
-
-
Shuai, K.1
Liu, B.2
-
65
-
-
39749164515
-
Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
-
Milici AJ, Kudlacz EM, Audoly L, Zwillich S, Changelian P (2008) Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Arthritis Res Ther 10:R14
-
(2008)
Arthritis Res Ther
, vol.10
, pp. 14
-
-
Milici, A.J.1
Kudlacz, E.M.2
Audoly, L.3
Zwillich, S.4
Changelian, P.5
-
66
-
-
0242332186
-
Prevention of organ allograft rejection by a specifi c Janus kinase 3 inhibitor
-
Changelian PS, Flanagan ME, Ball DJ et al (2003) Prevention of organ allograft rejection by a specifi c Janus kinase 3 inhibitor. Science 302:875-878
-
(2003)
Science
, vol.302
, pp. 875-878
-
-
Changelian, P.S.1
Flanagan, M.E.2
Ball, D.J.3
-
67
-
-
84864716411
-
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
-
Fleischmann R, Kremer J, Cush J et al (2012) Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 367:495-507
-
(2012)
N Engl J Med
, vol.367
, pp. 495-507
-
-
Fleischmann, R.1
Kremer, J.2
Cush, J.3
-
68
-
-
84873707288
-
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
-
Burmester GR, Blanco R, Charles-Schoeman C et al (2013) Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 381:451-460
-
(2013)
Lancet
, vol.381
, pp. 451-460
-
-
Burmester, G.R.1
Blanco, R.2
Charles-Schoeman, C.3
-
69
-
-
84865013186
-
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
-
Sandborn WJ, Ghosh S, Panes J et al (2012) Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med 367:616-624
-
(2012)
N Engl J Med
, vol.367
, pp. 616-624
-
-
Sandborn, W.J.1
Ghosh, S.2
Panes, J.3
-
70
-
-
70349736206
-
Double-blind, placebo-controlled, doseescalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis
-
Boy MG, Wang C, Wilkinson BE et al (2009) Double-blind, placebo-controlled, doseescalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis. J Invest Dermatol 129:2299-2302
-
(2009)
J Invest Dermatol
, vol.129
, pp. 2299-2302
-
-
Boy, M.G.1
Wang, C.2
Wilkinson, B.E.3
-
71
-
-
84893772728
-
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
-
Smolen JS, Landewe R, Breedveld FC et al (2014) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 73:492-509
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 492-509
-
-
Smolen, J.S.1
Landewe, R.2
Breedveld, F.C.3
-
72
-
-
84880257603
-
How Cytokine networks fuel infl ammation: Interleukin-17 and a tale of two autoimmune diseases
-
Baeten DL, Kuchroo VK (2013) How Cytokine networks fuel infl ammation: interleukin-17 and a tale of two autoimmune diseases. Nat Med 19:824-825
-
(2013)
Nat Med
, vol.19
, pp. 824-825
-
-
Baeten, D.L.1
Kuchroo, V.K.2
-
73
-
-
84901824681
-
The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis
-
Yeremenko N, Paramarta JE, Baeten D (2014) The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis. Curr Opin Rheumatol 26:361-370
-
(2014)
Curr Opin Rheumatol
, vol.26
, pp. 361-370
-
-
Yeremenko, N.1
Paramarta, J.E.2
Baeten, D.3
-
74
-
-
84886099419
-
A tale of two specifi cities: Bispecifi c antibodies for therapeutic and diagnostic applications
-
Byrne H, Conroy PJ, Whisstock JC, O’Kennedy RJ (2013) A tale of two specifi cities: bispecifi c antibodies for therapeutic and diagnostic applications. Trends Biotechnol 31: 621-632
-
(2013)
Trends Biotechnol
, vol.31
, pp. 621-632
-
-
Byrne, H.1
Conroy, P.J.2
Whisstock, J.C.3
O’Kennedy, R.J.4
-
75
-
-
84901311724
-
Anti-CD22/CD20 Bispecifi c antibody with enhanced trogocytosis for treatment of Lupus
-
Rossi EA, Chang CH, Goldenberg DM (2014) Anti-CD22/CD20 Bispecifi c antibody with enhanced trogocytosis for treatment of Lupus. PLoS One 9:e98315
-
(2014)
Plos One
, pp. 9
-
-
Rossi, E.A.1
Chang, C.H.2
Goldenberg, D.M.3
-
76
-
-
84877602531
-
The ascent of acetylation in the epigenetics of rheumatoid arthritis
-
Grabiec AM, Reedquist KA (2013) The ascent of acetylation in the epigenetics of rheumatoid arthritis. Nat Rev Rheumatol 9:311-318
-
(2013)
Nat Rev Rheumatol
, vol.9
, pp. 311-318
-
-
Grabiec, A.M.1
Reedquist, K.A.2
-
77
-
-
79955552937
-
Safety and effi cacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
-
Vojinovic J, Damjanov N, D’Urzo C et al (2011) Safety and effi cacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 63:1452-1458
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1452-1458
-
-
Vojinovic, J.1
Damjanov, N.2
D’Urzo, C.3
|