Magnetic ferroferric oxide nanoparticles induce vascular endothelial cell dysfunction and inflammation by disturbing autophagy

Journal of Hazardous Materials

Volumn 304, Issue , 2016, Pages 186-195

  Zhang, Lu ^a   Wang, XueQin ^a   Miao, YiMing ^a   Chen, ZhiQiang ^a   Qiang, PengFei ^a   Cui, LiuQing ^a   Jing, Hongjuan ^a   Guo, YuQi ^b  

^a HENAN UNIVERSITY OF TECHNOLOGY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

Autophagy dysfunction; Endothelial dysfunction; Inflammation; Magnetic ferroferric oxide nanoparticles

Indexed keywords

CELL DEATH; MAGNETISM; NANOMAGNETICS; NANOPARTICLES; NITRIC OXIDE; PATHOLOGY;

AUTOPHAGOSOMES; AUTOPHAGY; BIOLOGICAL BEHAVIOR; ENDOTHELIAL DYSFUNCTION; FERROFERRIC OXIDES; INFLAMMATION; PRO-INFLAMMATORY CYTOKINES; VASCULAR ENDOTHELIAL CELLS;

ENDOTHELIAL CELLS;

BECLIN 1; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LIGHT CHAIN 3 II; MAGNETIC FERROFERRIC OXIDE NANOPARTICLE; MAMMALIAN TARGET OF RAPAMYCIN; METAL NANOPARTICLE; MYOSIN LIGHT CHAIN; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG; C REACTIVE PROTEIN; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; MAGNETITE NANOPARTICLE; NOS3 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

APOPTOSIS; CELLS AND CELL COMPONENTS; CONCENTRATION (COMPOSITION); ENZYME ACTIVITY; MAGNETIC FIELD; NANOPARTICLE; NITRIC OXIDE; OXIDE; PROTEIN; TOXICITY;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL VIABILITY; CYTOKINE PRODUCTION; ENDOTHELIAL DYSFUNCTION; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; METABOLISM; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

APOPTOSIS; AUTOPHAGY; C-REACTIVE PROTEIN; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; MAGNETITE NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84946430942     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2015.10.041     Document Type: Article

References (38)

1. Williams D.F. On the nature of biomaterials. Biomaterials 2009, 30:5897-5909.
2. Jha R.K., Jha P.K., Chaudhury K., Rana S.V., Guha S.K. An emerging interface between life science and nanotechnology: present status and prospects of reproductive healthcare aided by nano-biotechnology. Nano Rev. eCollection 2014.
3. Buzea C., Pacheco C., Robbie K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007, 2:MR17-MR71.
4. Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008, 4:26-49.
5. Donaldson K., Duffin R., Langrish J.P., Miller M.R., Mills N.L., Poland C.A., Raftis J., Shah A., Shaw C.A., Newby D.E. Nanoparticles and the cardiovascular system: a critical review. Nanomedicine (Lond.) 2013, 8:403-423.
6. Zhu M.T., Feng W.Y., Wang Y., Wang B., Wang M., Ouyang H., Zhao Y.L., Chai Z.F. Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxidenanoparticles in rats and the potential health risk assessment. Toxicol. Sci. 2009, 107:342-351.
7. Du Z., Zhao D., Jing L., Cui G., Jin M., Li Y., Liu X., Liu Y., Du H., Guo C., Zhou X., Sun Z. Cardiovascular toxicity of different sizes amorphous silica nanoparticles in rats after intratracheal instillation. Cardiovasc. Toxicol. 2013, 13:194-207.
8. Peters K., Unger R.E., Kirkpatrick C.J., Gatti A.M., Monari E. Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation. J. Mater. Sci. Mater. Med. 2004, 15:321-325.
9. Häfeli U.O., Riffle J.S., Harris-Shekhawat L., Carmichael-Baranauskas A., Mark F., Dailey J.P., Bardenstein D. Cell uptake and in vitro toxicity of magnetic nanoparticles suitable for drug delivery. Mol. Pharm. 2009, 6:1417-1428.
10. Laurent S., Saei A.A., Behzadi S., Panahifar A., Mahmoudi M. Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges. Expert Opin. Drug. Deliv. 2014, 11:1449-1470.
11. Xu C., Sun S. New forms of superparamagnetic nanoparticles for biomedical applications. Adv. Drug Deliv. Rev. 2013, 65:732-743.
12. 4. Molecules 2014, 19:21506-21528.
13. Liao S.H., Liu C.H., Bastakoti B.P., Suzuki N., Chang Y., Yamauchi Y., Lin F.H., Wu K.C. Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia. Int. J. Nanomed. 2015, 10:3315-3327.
14. Zhu M.T., Wang Y., Feng W.Y., Wang B., Wang M., Ouyang H., Chai Z.F. Oxidative stress and apoptosis induced by iron oxide nanoparticles in cultured human umbilical endothelial cells. J. Nanosci. Nanotechnol. 2010, 10:8584-8590.
15. Su L., Han L., Ge F., Zhang S.L., Zhang Y., Zhao B.X., Zhao J., Miao J.Y. The effect of novel magnetic nanoparticles on vascular endothelial cell function in vitro and in vivo. J. Hazard. Mater. 2012, 235-236:316-325.
16. Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 1973, 52:2745-2756.
17. Wang X., Wang L., Tan X., Zhang H., Sun G. Construction of doxorubicin-loading magnetic nanocarriers for assaying apoptosis of glioblastoma cells. J. Colloid Interface Sci. 2014, 436:267-275.
18. Voyta J.C., Via D.P., Butterfield C.E., Zetter B.R. Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell Biol. 1984, 99:2034-2040.
19. Mains R.E., May V. The role of a low pH intracellular compartment in the processing storage, and secretion of ACTH and endorphin. J. Biol. Chem. 1988, 263:7887-7894.
20. Paglin S., Hollister T., Delohery T., Hackett N., McMahill M., Sphicas E., Domingo D., Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res. 2001, 61:439-444.
21. Zhang L., Dai F., Cui L., Jing H., Fan P., Tan X., Guo Y., Zhou G. Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells. Biochim. Biophys. Acta 2015, 1853:377-387.
22. Klionsky D.J., Abdalla F.C., Abeliovich H., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544.
23. Bjørkøy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
24. Kanematsu S., Uehara N., Miki H., Yoshizawa K., Kawanaka A., Yuri T., Tsubura A. Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells. Anticancer Res. 2010, 30:3381-3390.
25. Strømhaug P.E., Berg T.O., Gjøen T., Seglen P.O. Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes. Eur. J. Biol. 1997, 73:28-39.
26. Orecna M., De Paoli S.H., Janouskova O., Tegegn T.Z., Filipova M., Bonevich J.E., Holada K., Simak J. Toxicity of carboxylated carbon nanotubes in endothelial cells is attenuated by stimulation of the autophagic flux with the release of nanomaterial in autophagic vesicles. Nanomedicine 2014, 10:939-948.
27. Zhu M.T., Feng W.Y., Wang B., Wang T.C., Gu Y.Q., Wang M., Wang Y., Ouyang H., Zhao Y.L., Chai Z.F. Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Toxicology 2008, 247:102-111.
28. Channon K.M., Qian H., George S.E. Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy. Arterioscler. Thromb. Vasc. Biol. 2000, 20:1873-1881.
29. Ridker P.M. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 2003, 107:363-369.
30. Zhu M.T., Wang B., Wang Y., Yuan L., Wang H.J., Wang M., Ouyang H., Chai Z.F., Feng W.Y., Zhao Y.L. Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: risk factors for early atherosclerosis. Toxicol. Lett. 2011, 203:162-171.
31. 4 magnetic nanoparticles on A549 cells. Int. J. Mol. Sci. 2013, 14:15546-15560.
32. Shi M., Cheng L., Zhang Z., Liu Z., Mao X. Ferroferric oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin1/Bcl-2/VPS34 complex. Int. J. Nanomed. 2014, 10:207-216.
33. Halamoda Kenzaoui B., Chapuis Bernasconi C., Guney-Ayra S., Juillerat-Jeanneret L. Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells. Biochem. J. 2012, 441:813-821.
34. Klionsky D.J. Coming soon to a journal near you-the updated guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2014, 10:1691.
35. Stern S.T., Adiseshaiah P.P., Crist R.M. Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part. Fibre Toxicol. 2012, 9:20.
36. Li R., Ji Z., Qin H., Kang X., Sun B., Wang M., Chang C.H., Wang X., Zhang H., Zou H., Nel A.E., Xia T. Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagy flux and regulation of an interleukin-1β producing inflammasome. ACS Nano 2014, 8:10280-10292.
37. Duan J., Yu Y., Yu Y., Li Y., Wang J., Geng W., Jiang L., Li Q., Zhou X., Sun Z. Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway. Int. J. Nanomed. 2014, 9:5131-5141.
38. Yuk J.M., Jo E.K. Crosstalk between autophagy and inflammasomes. Mol. Cells 2013, 36:393-399.