Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Aziz, Ramy K ^a,b   Monk, Jonathan M ^b   Lewis, Robert M ^c   In Loh, Suh ^d   Mishra, Arti ^d   Abhay Nagle, Amrita ^d   Satyanarayana, Chitkala ^d   Dhakshinamoorthy, Saravanakumar ^d   Luche, Michele ^c   Kitchen, Douglas B ^c   Andrews, Kathleen A ^b   Fong, Nicole L ^b   Li, Howard J ^b   Palsson, Bernhard O ^b   Charusanti, Pep ^b,e  

^a CAIRO UNIVERSITY   (Egypt)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c ALBANY MOLECULAR RESEARCH INC   (United States)

^d Pte Ltd   (Singapore)

^e Chalmers University of Technology   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DRUG COMBINATION;

BIOLOGICAL MODEL; DRUG COMBINATION; DRUG DEVELOPMENT; ESCHERICHIA COLI O157; FOOD POISONING; GENETICS; GROWTH, DEVELOPMENT AND AGING; KLEBSIELLA PNEUMONIAE; LETHAL GENE; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PROCEDURES; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SYNTHESIS; SYSTEMS BIOLOGY; THEORETICAL MODEL; YERSINIA PESTIS;

ANTI-BACTERIAL AGENTS; DRUG COMBINATIONS; DRUG DISCOVERY; ESCHERICHIA COLI O157; FOODBORNE DISEASES; GENES, LETHAL; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; SALMONELLA TYPHIMURIUM; SYSTEMS BIOLOGY; YERSINIA PESTIS;

EID: 84946226477     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16025     Document Type: Article

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