Combinations of alkaloids affecting different molecular targets with the saponin digitonin can synergistically enhance trypanocidal activity against Trypanosoma brucei brucei

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 11, 2015, Pages 7011-7017

  Krstin, Sonja ^a   Peixoto, Herbenya Silva ^a   Wink, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; ANTITRYPANOSOMAL AGENT; BERBERINE; CHELERYTHRINE; DIGITONIN; DNA; EMETINE; HOMOHARRINGTONINE; PIPERINE; SAPONIN; VINBLASTINE; 1,3 BENZODIOXOLE DERIVATIVE; AMIDE; BENZOPHENANTHRIDINE DERIVATIVE; DRUG COMBINATION; HARRINGTONINE DERIVATIVE; PIPERIDINE DERIVATIVE;

ANTIMALARIAL ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; FACILITATION; INTERCALATION COMPLEX; MEMBRANE BIOLOGY; MEMBRANE PERMEABILITY; MICROTUBULE ASSEMBLY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRYPANOCIDAL ACTIVITY; TRYPANOSOMA BRUCEI BRUCEI; ANIMAL; DRUG COMBINATION; DRUG EFFECTS; DRUG POTENTIATION; THEORETICAL MODEL;

ALKALOIDS; ANIMALS; BENZODIOXOLES; BENZOPHENANTHRIDINES; BERBERINE; DIGITONIN; DRUG COMBINATIONS; DRUG SYNERGISM; EMETINE; HARRINGTONINES; MODELS, THEORETICAL; PIPERIDINES; POLYUNSATURATED ALKAMIDES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; VINBLASTINE;

EID: 84946201894     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01315-15     Document Type: Article

References (37)

1. Wink M. 2012. Medicinal plants: a source of anti-parasitic secondary metabolites. Molecules 17:12771-12791. http://dx.doi.org/10.3390/molecules171112771.
2. World Health Organization. 2014. Trypanosomiasis, human African (sleeping sickness). World Health Organization, Geneva, Switzerland. http://www.who.int/mediacentre/factsheets/fs259/en/. Accessed 11 December 2014.
3. Morrison LJ. 2011. Parasite-driven pathogenesis in Trypanosoma brucei infections. Parasite Immunol 33:448-455. http://dx.doi.org/10.1111/j.1365-3024.2011.01286.x.
4. Gehrig S, Efferth T. 2008. Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural products (review). Int J Mol Med 22:411-419.
5. Hannaert V. 2011. Sleeping sickness pathogen (Trypanosoma brucei) and natural products: therapeutic targets and screening systems. Planta Med 77:586-597. http://dx.doi.org/10.1055/s-0030-1250411.
6. Horn D, Duraisingh MT 2014. Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol 54:71-94. http://dx.doi.org/10.1146/annurev-pharmtox-011613-135915.
7. Van Wyk B., Wink M. 2004. Medicinal plants of the world. Briza Publications, Pretoria, South Africa.
8. Santos NN, Menezes LR, dos Santos JA, Meira CS, Guimarhes ET, Soares MB, Nepel A, Barisone A., Costa EV. 2014. A new source of (R)-limonene and rotundifolone from leaves of Lippia pedunculosa (Verbenaceae) and their trypanocidal properties. Nat Prod Commun 9:737-739.
9. Herrmann F, Hamoud R, Sporer F., Tahrani A, Wink M. 2011. Carlina oxide - a natural polyacetylene from Carlina acaulis (Asteraceae) with potent antrypanosomial and antimicrobial properties. Planta Med 77: 1905-1911. http://dx.doi.org/10.1055/s-0031-1279984.
10. Nibret E, Youns M, Krauth-Siegel RL, Wink M. 2011. Biological activities of xanthatin from Xanthium strumarium leaves. Phytother Res 25: 1883-1890. http://dx.doi.org/10.1002/ptr.3651.
11. Wink M. 2005. Die Verwendung pflanzlicher Vielstoffgemische in der Phytotherapie: eine evolutionaere Sichtweise. Phytotherapie 5:33-39.
12. Wink M. 2008. Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine. Curr Drug Metab 9:996-1009. http://dx.doi.org/10.2174/138920008786927794.
13. Heinrich M, Maizels D, Gibbons S. 2004. Fundamentals of pharmacognosy and phytotherapy. Churchill Livingstone, Edinburgh, United Kingdom.
14. Chou TC. 2006. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58:621-681. http://dx.doi.org/10.1124/pr.58.3.10.
15. Roberts MF, Wink M. 1998. Alkaloids: biochemistry, ecology and medicinal applications. Plenum Press, New York, NY.
16. Wink M. 1993. Allelochemical properties and the raison d'être of alkaloids. Alkaloids 43:1-118.
17. Wink M. 2000. Interference of alkaloids with neuroreceptors and ion channels. Stud Nat Prod Chem 21:3-129. http://dx.doi.org/10.1016/S1572-5995(00)80004-6.
18. Wink M. 2007. Molecular modes of action of cytotoxic alkaloids: from DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance. Alkaloids Chem Biol 64:1-47. http://dx.doi.org/10.1016/S1099-4831(07)64001-2.
19. Jung Jang E., Kil YS, Ryeon Park H, Oh S, Kyeong Kim H, Gyeong Jeong M, Kyoung Seo E, Sook Hwang E. 2014. Suppression of IL-2 production and proliferation of CD4(+) T cells by tuberostemonine O. Chem Biodivers 11:1954-1962. http://dx.doi.org/10.1002/cbdv.201400074.
20. Imperatore C, Aiello A, D'Aniello F, Senese M, Menna M. 2014. Alkaloids from marine invertebrates as important leads for anticancer drugs discovery and development. Molecules 19:20391-20423. http://dx.doi.org/10.3390/molecules191220391.
21. Haznedaroglu MZ, Gokce G. 2014. Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop. Acta Biol Hung 65:396-404. http://dx.doi.org/10.1556/ABiol.65.2014.4.4.
22. Eid SY, El-Readi MZ, Wink M. 2012. Digitonin synergistically enhances the cytotoxicity of plant secondary metabolites in cancer cells. Phytomedicine 19:1307-1314. http://dx.doi.org/10.1016/j.phymed.2012.09.002.
23. Merschjohann K, Sporer F, Steverding D., Wink M. 2001. In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. Planta Med 67:623-627. http://dx.doi.org/10.1055/s-2001-17351.
24. Wink M, Latz-Brüning B, Schmeller T. 1999. Biochemical effects of allelopathic alkaloids, p 411-422. In Principles and Practices in Plant Ecology. CRC Press, Boca Raton, FL, USA.
25. Hellmann JK, Münter S, Wink M., Frischknecht F. 2010. Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporozoite survival and motility. PLoS One 5:e8682. http://dx.doi.org/10.1371/journal.pone.0008682.
26. Baltz T, Baltz D, Giroud C., Crockett J. 1985. Cultivation in a semidefined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J 4:1273-1277.
27. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63. http://dx.doi.org/10.1016/0022-1759(83)90303-4.
28. Chou TC. 2010. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 70:440-446. http://dx.doi.org/10.1158/0008-5472.CAN-09-1947.
29. Zhao L, Wientjes MG, Au JL 2004. Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin Cancer Res 10:7994-8004. http://dx.doi.org/10.1158/1078-0432.CCR-04-1087.
30. Chou TC, Talalay P. 1984. Quantitative analysis of dose - effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27-55. http://dx.doi.org/10.1016/0065-2571(84)90007-4.
31. Wink M, Schimmer O. 2010. Molecular modes of action of defensive secondary metabolites, p 21-161. In Annual plant reviews, Volume 39: functions and biotechnology of plant secondary metabolites, 2nd ed. Wiley, Oxford, United Kingdom.
32. Rosenkranz V, Wink M. 2008. Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei). Molecules 13:2462-2473. http://dx.doi.org/10.3390/molecules13102462.
33. Cabrespine A, Bay JO, Barthomeuf C, Curé H, Chollet P, Debiton E. 2005. In vitro assessment of cytotoxic agent combinations for hormonerefractory prostate cancer treatment. Anticancer Drugs 16:417-422. http://dx.doi.org/10.1097/00001813-200504000-00008.
34. Jekunen AP, Shalinsky DR, Hom D.K., Albright KD, Heath D, Howell SB. 1993. Modulation of cisplatin cytotoxicity by permeabilization of the plasma membrane by digitonin in vitro. Biochem Pharmacol 45:2079-2085. http://dx.doi.org/10.1016/0006-2952(93)90019-S.
35. Eid SY, El-Readi MZ, Eldin EEMN, Fatani SH, Wink M. 2013. Influence of combinations of digitonin with selected phenolics, terpenoids and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. Phytomedicine 21:47-61. http://dx.doi.org/10.1016/j.phymed.2013.07.019.
36. Rautio J, Humphreys JE, Webster L.O., Balakrishnan A., Keogh JP, Kunta JR, Serabjit-Singh CJ, Polli JW. 2006. In vitro p-glycoprotein inhibition assay for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates. Drug Metab Dispos 34:786-792. http://dx.doi.org/10.1124/dmd.105.008615.
37. Campos MC, Castro-Pinto DB, Ribeiro G.A., Berredo-Pinho MM, Gomes LH, da Silva Bellieny MS, Goulart CM, Echevarria A, Leon LL. 2013. P-glycoprotein efflux pump playsanimportant role in Trypanosoma cruzi drug resistance. Parasitol Res 112:2341-2351. http://dx.doi.org/10.1007/s00436-013-3398-z.