메뉴 건너뛰기




Volumn 13, Issue 10, 2008, Pages 2462-2473

Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei)

Author keywords

Alkaloids; Apoptosis; Jurkat APO S; Leukemia; Programmed cell death; Trypanosoma brucei; Trypanosomiasis

Indexed keywords

ALKALOID; ANTITRYPANOSOMAL AGENT; INTERCALATING AGENT;

EID: 55249117688     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules13102462     Document Type: Article
Times cited : (76)

References (39)
  • 1
    • 0002112085 scopus 로고    scopus 로고
    • Current public health status of trypanosomiases and leishmaniases
    • Hide G, Mottram, J.C, Coombs, G.H, Holmes, P.H, Eds; CAB International: Wallington
    • Molyneux, D.H. Current public health status of trypanosomiases and leishmaniases. In Trypanosomiasis and leishmaniasis: biology and control; Hide G, Mottram, J.C., Coombs, G.H., Holmes, P.H., Eds; CAB International: Wallington, 1997; pp. 39-50.
    • (1997) Trypanosomiasis and leishmaniasis: Biology and control , pp. 39-50
    • Molyneux, D.H.1
  • 2
    • 0032971996 scopus 로고    scopus 로고
    • Measuring the costs of African animal trypanosomiasis, the potential benefits of control and returns to research
    • Kristjanson, P.M.; Swallow, B.M.; Rowlands, G.J.; Kruska, R.L.; de Leeuw, P.N. Measuring the costs of African animal trypanosomiasis, the potential benefits of control and returns to research. Agr. Syst. 1999, 59, 79-98.
    • (1999) Agr. Syst , vol.59 , pp. 79-98
    • Kristjanson, P.M.1    Swallow, B.M.2    Rowlands, G.J.3    Kruska, R.L.4    de Leeuw, P.N.5
  • 3
    • 0030883946 scopus 로고    scopus 로고
    • The current status of antiparasitic chemotherapy
    • 114, 3-15
    • Croft, S.L. The current status of antiparasitic chemotherapy. Parasitology 1997 (supplement), 114, 3-15.
    • (1997) Parasitology , Issue.SUPPL.EMENT
    • Croft, S.L.1
  • 4
    • 0001296743 scopus 로고    scopus 로고
    • Drug resistance in trypanosomatids
    • Hide G, Mottram, J.C, Coombs, G.H, Holmes, P.H, Eds; CAB International: Wallington
    • Ross, C.A.; Sutherland, D.V. Drug resistance in trypanosomatids. In Trypanosomiasis and leishmaniasis: biology and control; Hide G, Mottram, J.C., Coombs, G.H., Holmes, P.H., Eds; CAB International: Wallington, 1997; pp. 259-269.
    • (1997) Trypanosomiasis and leishmaniasis: Biology and control , pp. 259-269
    • Ross, C.A.1    Sutherland, D.V.2
  • 5
    • 0034815454 scopus 로고    scopus 로고
    • In vitro effects of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense
    • Merschjohann, K.; Sporer, F.; Steverding, D.; Wink, M. In vitro effects of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. Planta Med. 2001, 67, 623-627.
    • (2001) Planta Med , vol.67 , pp. 623-627
    • Merschjohann, K.1    Sporer, F.2    Steverding, D.3    Wink, M.4
  • 6
    • 34548606231 scopus 로고    scopus 로고
    • Induction of apoptosis by alkaloids, non-protein amino acids, and cardiac glycosides in human promyelotic HL-60 cels
    • Rosenkranz, V.; Wink, M. Induction of apoptosis by alkaloids, non-protein amino acids, and cardiac glycosides in human promyelotic HL-60 cels. Z. Naturforsch. 2007, 62c, 458-466.
    • (2007) Z. Naturforsch , vol.62 c , pp. 458-466
    • Rosenkranz, V.1    Wink, M.2
  • 7
    • 77957084883 scopus 로고
    • Allelochemical properties and the raison d'être of alkaloids
    • G. Cordell, Ed, Academic Press: Orlando, FL
    • Wink, M. Allelochemical properties and the raison d'être of alkaloids. In The Alkaloids, G. Cordell, Ed.; Academic Press: Orlando, FL, 1993; Vol. 43, pp. 1-118.
    • (1993) The Alkaloids , vol.43 , pp. 1-118
    • Wink, M.1
  • 8
    • 77957131858 scopus 로고    scopus 로고
    • Interference of alkaloids with neuroreceptors and ion channels
    • Elsevier: Amsterdam, New York;
    • Wink, M. Interference of alkaloids with neuroreceptors and ion channels. In Bioactive natural products; Atta-Ur-Rahman, Ed.; Elsevier: Amsterdam, New York; 2000; Vol. 11, pp. 3-129.
    • (2000) Bioactive natural products; Atta-Ur-Rahman, Ed , vol.11 , pp. 3-129
    • Wink, M.1
  • 9
    • 55249091880 scopus 로고    scopus 로고
    • Wink, M.; Schimmer, O. Modes of action of defensive secondary metabolites. In Function of Plant secondary metabolites and their exploitation in biotechnology; Wink, M., Ed.; Annual Plant Reviews; Sheffield Academic Press: Sheffield, 1999; 3, pp. 17-133.
    • Wink, M.; Schimmer, O. Modes of action of defensive secondary metabolites. In Function of Plant secondary metabolites and their exploitation in biotechnology; Wink, M., Ed.; Annual Plant Reviews; Sheffield Academic Press: Sheffield, 1999; Vol. 3, pp. 17-133.
  • 10
    • 36049040984 scopus 로고    scopus 로고
    • Molecular modes of action of cytotoxic alkaloids - From DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance
    • Cordell, G, Ed, Elsevier: Amsterdam, New York;
    • Wink, M. Molecular modes of action of cytotoxic alkaloids - From DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance. In The Alkaloids; Cordell, G., Ed.; Elsevier: Amsterdam, New York; 2007; Vol. 64, pp. 1-48.
    • (2007) The Alkaloids , vol.64 , pp. 1-48
    • Wink, M.1
  • 12
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging complication in tissue kinetics
    • Kerr; J.B.; Wyllie, A.H.; Currie, A.R. Apoptosis: a basic biological phenomenon with wide-ranging complication in tissue kinetics. Br. J. Cancer 1972; 26, 239-57
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.B.1    Wyllie, A.H.2    Currie, A.R.3
  • 13
    • 0033491193 scopus 로고    scopus 로고
    • CD95(APO-1/Fas)-mediated apoptosis: Live and let die
    • Krammer, H. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv. Immunol. 1999, 71, 163-210.
    • (1999) Adv. Immunol , vol.71 , pp. 163-210
    • Krammer, H.1
  • 14
    • 0035229427 scopus 로고    scopus 로고
    • The mitochondrion in apoptosis: How Pandora's box opens
    • Zamzami, N.; Kroemer, G. The mitochondrion in apoptosis: how Pandora's box opens. Nature Rev. Mol. Cell Biol. 2001, 2, 67-71.
    • (2001) Nature Rev. Mol. Cell Biol , vol.2 , pp. 67-71
    • Zamzami, N.1    Kroemer, G.2
  • 15
    • 0031788303 scopus 로고    scopus 로고
    • Modes of action of allelochemical alkaloids: Interaction with neuroreceptors, DNA and other molecular targets
    • Wink, M.; Schmeller, T.; Latz-Brüning, B. Modes of action of allelochemical alkaloids: Interaction with neuroreceptors, DNA and other molecular targets. J. Chem. Ecol. 1998, 24, 1881-1937.
    • (1998) J. Chem. Ecol , vol.24 , pp. 1881-1937
    • Wink, M.1    Schmeller, T.2    Latz-Brüning, B.3
  • 16
    • 23044471302 scopus 로고    scopus 로고
    • Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): Implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival
    • Ameisen, J.-C.; Idziorek, T.; Billaut-Multo, O.; Loyens, M.; Yissier, J.-P.; Potentier, A; Ouai, A. Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): Implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival. Parasitol. Today 1996, 12, 49.
    • (1996) Parasitol. Today , vol.12 , pp. 49
    • Ameisen, J.-C.1    Idziorek, T.2    Billaut-Multo, O.3    Loyens, M.4    Yissier, J.-P.5    Potentier, A.6    Ouai, A.7
  • 18
    • 0000146018 scopus 로고    scopus 로고
    • Baltz, T.; Baltz, C.; Giroud, C.; Crockett, J. Cultivation in a semi-defined medium of animal infective forms of Trypansoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J. 1985, 4, 1273-1277.
    • Baltz, T.; Baltz, C.; Giroud, C.; Crockett, J. Cultivation in a semi-defined medium of animal infective forms of Trypansoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J. 1985, 4, 1273-1277.
  • 19
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti, I.G.; Migliorati, M.C.; Pagliacci, F.; Grignani, F.; Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Meth. 1991, 139, 271-279.
    • (1991) J. Immunol. Meth , vol.139 , pp. 271-279
    • Nicoletti, I.G.1    Migliorati, M.C.2    Pagliacci, F.3    Grignani, F.4    Riccardi, C.5
  • 20
    • 33751080092 scopus 로고    scopus 로고
    • Efficacy and mechanisms of alpha-solasonine-and alphasolamargine-induced cytolysis on two strains of Trypanosoma cruzi
    • Hall, C.A.; Hobby, T.; Cipollini, M. Efficacy and mechanisms of alpha-solasonine-and alphasolamargine-induced cytolysis on two strains of Trypanosoma cruzi. J. Chem. Ecol. 2006, 32, 2405-16.
    • (2006) J. Chem. Ecol , vol.32 , pp. 2405-2416
    • Hall, C.A.1    Hobby, T.2    Cipollini, M.3
  • 23
    • 77957226468 scopus 로고    scopus 로고
    • Natural products as potential antiparasitic drugs
    • Kayser, O.; Kiderlen, A, F.; Croft, S.L. Natural products as potential antiparasitic drugs. Stud. Nat. Prod. Chem. 2002, 26G, 779-848.
    • (2002) Stud. Nat. Prod. Chem , vol.26 G , pp. 779-848
    • Kayser, O.1    Kiderlen, A.F.2    Croft, S.L.3
  • 25
    • 0023107561 scopus 로고
    • Plant-derived alkaloids active against Trypanosoma cruzi
    • Cavin, J. C.; Krassner, S.M.; Rodriguez, E. Plant-derived alkaloids active against Trypanosoma cruzi. J. Ethnopharmacol. 1987, 19, 89-94.
    • (1987) J. Ethnopharmacol , vol.19 , pp. 89-94
    • Cavin, J.C.1    Krassner, S.M.2    Rodriguez, E.3
  • 26
    • 33745199861 scopus 로고    scopus 로고
    • Mackey, Z. B.; Baca, A. M.; Mallari, J. P.; Apsel, Beth; S., Anang; H., Elizabeth J.; Chiang, P. K.; Wolff, Brian; G., Kiplin R.; Williams, J.; McKerrow, J. H. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem. Biol. Drug Des. 2006, 67, 355-363.
    • Mackey, Z. B.; Baca, A. M.; Mallari, J. P.; Apsel, Beth; S., Anang; H., Elizabeth J.; Chiang, P. K.; Wolff, Brian; G., Kiplin R.; Williams, J.; McKerrow, J. H. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem. Biol. Drug Des. 2006, 67, 355-363.
  • 27
    • 55249087884 scopus 로고
    • Emetine and some related compounds in experimental Chagas' disease
    • Konopka, E. A.; Goble, F. C.; Prins, D. A. Emetine and some related compounds in experimental Chagas' disease. Antimicrob. Agents Chemother. 1965, 772-776.
    • (1965) Antimicrob. Agents Chemother , pp. 772-776
    • Konopka, E.A.1    Goble, F.C.2    Prins, D.A.3
  • 28
    • 0017047630 scopus 로고
    • In vitro antitrypanosomal activity of certain alkaloids against Trypanosoma lewisi
    • Hopp, K. H.; Cunningham, L. V.; Bromel, M. C.; Schermeister, L. J.; Khalil, S. K. Wahba. In vitro antitrypanosomal activity of certain alkaloids against Trypanosoma lewisi. Lloydia 1976, 39, 375-7.
    • (1976) Lloydia , vol.39 , pp. 375-377
    • Hopp, K.H.1    Cunningham, L.V.2    Bromel, M.C.3    Schermeister, L.J.4    Khalil, S.K.W.5
  • 29
    • 0016841771 scopus 로고
    • Trypanocide activity of some ellipticine derivatives against Trypanosoma cruzi cultured in vitro
    • Benard, J.; Nguyen Dat X.; Riou, G. Trypanocide activity of some ellipticine derivatives against Trypanosoma cruzi cultured in vitro. Compt. Rend. Sean.s Acad. Sci. Ser. D: Sci. Nat. 1975, 280, 1177-1180.
    • (1975) Compt. Rend. Sean.s Acad. Sci. Ser. D: Sci. Nat , vol.280 , pp. 1177-1180
    • Benard, J.1    Nguyen Dat, X.2    Riou, G.3
  • 30
    • 0032969774 scopus 로고    scopus 로고
    • Effects of some .beta.-carboline alkaloids on intact Trypanosoma cruzi epimastigotes
    • Rivas, P.; Cassels, B. K.; Morello, A.; Repetto, Y. Effects of some .beta.-carboline alkaloids on intact Trypanosoma cruzi epimastigotes. Comp. Biochem. Physiol. 1999, 122C, 27-31.
    • (1999) Comp. Biochem. Physiol , vol.122 C , pp. 27-31
    • Rivas, P.1    Cassels, B.K.2    Morello, A.3    Repetto, Y.4
  • 31
    • 30044436114 scopus 로고    scopus 로고
    • Control mechanisms of tubulin gene expression in Trypanosoma cruzi
    • da Silva, R. A.; Bartholomeu, D. C.; Teixeira, S. M. R. Control mechanisms of tubulin gene expression in Trypanosoma cruzi. Int. J. Parasitol. 2006, 36, 87-96.
    • (2006) Int. J. Parasitol , vol.36 , pp. 87-96
    • da Silva, R.A.1    Bartholomeu, D.C.2    Teixeira, S.M.R.3
  • 32
    • 0031964824 scopus 로고    scopus 로고
    • Inhibition of Trypanosoma cruzi growth in vitro by Solanum alkaloids. A comparison with ketoconazole
    • Chataing, B.; Concepcion, J. L.; Lobaton, R.; Usubillaga, A. Inhibition of Trypanosoma cruzi growth in vitro by Solanum alkaloids. A comparison with ketoconazole. Planta Med. 1998, 64, 31-36.
    • (1998) Planta Med , vol.64 , pp. 31-36
    • Chataing, B.1    Concepcion, J.L.2    Lobaton, R.3    Usubillaga, A.4
  • 33
    • 2942527544 scopus 로고    scopus 로고
    • Ribeiro, T. S.; Freire-de-Lima, L.; Previato, J. O.; Mendonca-Previato, L.; Heise, N.; Freire de Lima, M.E.. Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi. Bioorg. Med. Chem. Lett. 2004, 14, 3555-3558.
    • Ribeiro, T. S.; Freire-de-Lima, L.; Previato, J. O.; Mendonca-Previato, L.; Heise, N.; Freire de Lima, M.E.. Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi. Bioorg. Med. Chem. Lett. 2004, 14, 3555-3558.
  • 34
    • 0018052240 scopus 로고    scopus 로고
    • Astolfi F., S.; Pereira de Almeida, E. R.; Gander, E.S. The influence of hydroxyurea and colchicine on growth and morphology of Trypanosoma cruzi. Acta Trop. 1978, 35, 229-237.
    • Astolfi F., S.; Pereira de Almeida, E. R.; Gander, E.S. The influence of hydroxyurea and colchicine on growth and morphology of Trypanosoma cruzi. Acta Trop. 1978, 35, 229-237.
  • 37
    • 0038731167 scopus 로고    scopus 로고
    • Caspase-independent cell death in T lymphocytes
    • Jaattela M.; Tschopp J. Caspase-independent cell death in T lymphocytes. Nat. Immunol. 2003, 5, 416-423.
    • (2003) Nat. Immunol , vol.5 , pp. 416-423
    • Jaattela, M.1    Tschopp, J.2
  • 38
    • 1642491755 scopus 로고    scopus 로고
    • Mitochondrial effectors in caspase-independent cell death
    • Lorenzo H.K.; Susin S. A. Mitochondrial effectors in caspase-independent cell death. FEBS Lett 2004, 557, 14-20.
    • (2004) FEBS Lett , vol.557 , pp. 14-20
    • Lorenzo, H.K.1    Susin, S.A.2
  • 39
    • 2342560593 scopus 로고    scopus 로고
    • Caspase-independent cell death?
    • Lockshin R. A.; Zakewri Z. Caspase-independent cell death? Oncogene 2004, 23, 2766-2773.
    • (2004) Oncogene , vol.23 , pp. 2766-2773
    • Lockshin, R.A.1    Zakewri, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.