메뉴 건너뛰기




Volumn 83, Issue 6, 2015, Pages 543-551

Low-grade systemic inflammation and the development of metabolic diseases: From the molecular evidence to the clinical practice

Author keywords

Adipose tissue; Arteriosclerosis; Insulin resistance; Low grade systemic inflammation; Macrophages; Metabolic diseases; Type 2 diabetes

Indexed keywords

ADVANCED GLYCATION END PRODUCT; BIOLOGICAL MARKER; CYTOKINE; GAMMA INTERFERON; GLUCOSE TRANSPORTER; GLYCOSYLATED HEMOGLOBIN; INSULIN RECEPTOR SUBSTRATE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; VON WILLEBRAND FACTOR; ADIPOCYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTIN;

EID: 84946200370     PISSN: 00097411     EISSN: 2444054X     Source Type: Journal    
DOI: 10.1016/J.CIRCEN.2015.11.008     Document Type: Article
Times cited : (89)

References (45)
  • 1
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98-107.
    • (2011) Nat Rev Immunol , vol.11 , Issue.2 , pp. 98-107
    • Donath, MY1    Shoelson, SE.2
  • 2
    • 84878469691 scopus 로고    scopus 로고
    • Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences
    • Van Greevenbroek MM, Schalkwijk CG, Stehouwer CD. Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences. Neth J Med. 2013;71(4):174-87.
    • (2013) Neth J Med , vol.71 , Issue.4 , pp. 174-187
    • Van Greevenbroek, MM1    Schalkwijk, CG2    Stehouwer, CD.3
  • 3
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796-808.
    • (2003) J Clin Invest , vol.112 , Issue.12 , pp. 1796-1808
    • Weisberg, SP1    McCann, D2    Desai, M3    Rosenbaum, M4    Leibel, RL5    Ferrante, AW6
  • 4
    • 80052857420 scopus 로고    scopus 로고
    • High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation
    • Feng D, Tang Y, Kwon H, Zong H, Hawkins M, Kitsis RN, et al. High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation. Diabetes. 2011;60(8):2134-43.
    • (2011) Diabetes , vol.60 , Issue.8 , pp. 2134-2143
    • Feng, D1    Tang, Y2    Kwon, H3    Zong, H4    Hawkins, M5    Kitsis, RN6
  • 5
    • 84890504097 scopus 로고    scopus 로고
    • Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation
    • Kitamura H, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, et al. Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. FASEB J. 2013;27(12):4940-53.
    • (2013) FASEB J , vol.27 , Issue.12 , pp. 4940-4953
    • Kitamura, H1    Kimura, S2    Shimamoto, Y3    Okabe, J4    Ito, M5    Miyamoto, T6
  • 6
    • 50949108719 scopus 로고    scopus 로고
    • Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
    • Murano I, Barbatelli G, Parisani V, Latini C, Muzzonigro G, Castellucci M, et al. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res. 2008;49(7):1562-8.
    • (2008) J Lipid Res , vol.49 , Issue.7 , pp. 1562-1568
    • Murano, I1    Barbatelli, G2    Parisani, V3    Latini, C4    Muzzonigro, G5    Castellucci, M6
  • 8
    • 84866107224 scopus 로고    scopus 로고
    • Lymphocytes in obesity-related adipose tissue inflammation
    • Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia. 2012;55(10):2583-92.
    • (2012) Diabetologia , vol.55 , Issue.10 , pp. 2583-2592
    • Chatzigeorgiou, A1    Karalis, KP2    Bornstein, SR3    Chavakis, T.4
  • 9
    • 84900872494 scopus 로고    scopus 로고
    • Adipose tissue in obesity-related inflammation and insulin resistance: cells cytokines, and chemokines
    • Makki K, Froguel P, Wolowczuk I. Adipose tissue in obesity-related inflammation and insulin resistance: cells cytokines, and chemokines. ISRN Inflamm. 2013;22:139239.
    • (2013) ISRN Inflamm , vol.22 , pp. 139239
    • Makki, K1    Froguel, P2    Wolowczuk, I.3
  • 11
    • 79959242498 scopus 로고    scopus 로고
    • Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
    • Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, Ryffel B, et al. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature. 2011;474(7351):385-9.
    • (2011) Nature , vol.474 , Issue.7351 , pp. 385-389
    • Sander, LE1    Davis, MJ2    Boekschoten, MV3    Amsen, D4    Dascher, CC5    Ryffel, B6
  • 12
    • 39449112512 scopus 로고    scopus 로고
    • Toll-like receptors - taking an evolutionary approach
    • Leulier F, Lemaitre B. Toll-like receptors - taking an evolutionary approach. Nat Rev Genetics. 2008;9(3):165-78.
    • (2008) Nat Rev Genetics , vol.9 , Issue.3 , pp. 165-178
    • Leulier, F1    Lemaitre, B.2
  • 13
    • 84862059730 scopus 로고    scopus 로고
    • Increased toll-like receptor activity in patients with metabolic syndrome
    • Jialal I, Huet BA, Kaur H, Chien A, Devaraj S. Increased toll-like receptor activity in patients with metabolic syndrome. Diabetes Care. 2012;35(4):900-4.
    • (2012) Diabetes Care , vol.35 , Issue.4 , pp. 900-904
    • Jialal, I1    Huet, BA2    Kaur, H3    Chien, A4    Devaraj, S.5
  • 14
    • 70349239156 scopus 로고    scopus 로고
    • Fatty acids as metabolic mediators in innate immunity
    • Kopp A, Gross P, Falk W, Bala M, Weigert J, Buechler C, et al. Fatty acids as metabolic mediators in innate immunity. Eur J Clin Invest. 2009;39(10):924-33.
    • (2009) Eur J Clin Invest , vol.39 , Issue.10 , pp. 924-933
    • Kopp, A1    Gross, P2    Falk, W3    Bala, M4    Weigert, J5    Buechler, C6
  • 15
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. 2008;8(12):923-34.
    • (2008) Nat Rev Immunol , vol.8 , Issue.12 , pp. 923-934
    • Hotamisligil, GS1    Erbay, E.2
  • 16
    • 83355164502 scopus 로고    scopus 로고
    • Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro
    • Youssef-Elabd EM, McGee KC, Tripathi G, Aldaghri N, Abdalla MS, Sharada HM, et al. Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro. J Nutr Biochem. 2012;23(1):39-50.
    • (2012) J Nutr Biochem , vol.23 , Issue.1 , pp. 39-50
    • Youssef-Elabd, EM1    McGee, KC2    Tripathi, G3    Aldaghri, N4    Abdalla, MS5    Sharada, HM6
  • 17
    • 0036853543 scopus 로고    scopus 로고
    • Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime
    • Steinberg D. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med. 2002;8(11):1211-7.
    • (2002) Nat Med , vol.8 , Issue.11 , pp. 1211-1217
    • Steinberg, D.1
  • 18
    • 84893680377 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2
    • Lee HY, Oh E, Kim SD, Seo JK, Bae YS. Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2. Biochem Biophys Res Commun. 2014;443(3):1003-7.
    • (2014) Biochem Biophys Res Commun , vol.443 , Issue.3 , pp. 1003-1007
    • Lee, HY1    Oh, E2    Kim, SD3    Seo, JK4    Bae, YS.5
  • 19
    • 84891887984 scopus 로고    scopus 로고
    • OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation
    • Liu W, Yin Y, Zhou Z, He M, Dai Y. OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation. Inflamm Res. 2014;63(1):33-43.
    • (2014) Inflamm Res , vol.63 , Issue.1 , pp. 33-43
    • Liu, W1    Yin, Y2    Zhou, Z3    He, M4    Dai, Y.5
  • 20
    • 77955851805 scopus 로고    scopus 로고
    • The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway
    • Geng H, Wang A, Rong G, Zhu B, Deng Y, Chen J, et al. The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway. Mol Cell Biochem. 2010;342(1-2):201-6.
    • (2010) Mol Cell Biochem , vol.342 , Issue.1-2 , pp. 201-206
    • Geng, H1    Wang, A2    Rong, G3    Zhu, B4    Deng, Y5    Chen, J6
  • 21
    • 74549184092 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: a sensor for metabolic danger?
    • Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010;327(5963): 296-300.
    • (2010) Science , vol.327 , Issue.5963 , pp. 296-300
    • Schroder, K1    Zhou, R2    Tschopp, J.3
  • 22
    • 84555203361 scopus 로고    scopus 로고
    • Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells
    • Iwata NG, Pham M, Rizzo NO, Cheng AM, Maloney E, Kim F. Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells. PLoS One. 2011;6(12):e29600.
    • (2011) PLoS One , vol.6 , Issue.12 , pp. e29600
    • Iwata, NG1    Pham, M2    Rizzo, NO3    Cheng, AM4    Maloney, E5    Kim, F.6
  • 23
    • 33645891172 scopus 로고    scopus 로고
    • Cytokines in atherosclerosis: pathogenic and regulatory pathways
    • Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev. 2006;86(2):515-81.
    • (2006) Physiol Rev , vol.86 , Issue.2 , pp. 515-581
    • Tedgui, A1    Mallat, Z.2
  • 24
    • 0006401474 scopus 로고    scopus 로고
    • Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism
    • Frostegård J, Huang YH, Rönnelid J, Schäfer-Elinder L. Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism. Arterioscler Thromb Vasc Biol. 1997;17(5):963-8.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , Issue.5 , pp. 963-968
    • Frostegård, J1    Huang, YH2    Rönnelid, J3    Schäfer-Elinder, L.4
  • 25
    • 0032494161 scopus 로고    scopus 로고
    • Lysophosphatidylcholine enhances cytokine-induced interferon gamma expression in human T lymphocytes
    • Nishi E, Kume N, Ueno Y, Ochi H, Moriwaki H, Kita T. Lysophosphatidylcholine enhances cytokine-induced interferon gamma expression in human T lymphocytes. Circ Res. 1998;83(5):508-15.
    • (1998) Circ Res , vol.83 , Issue.5 , pp. 508-515
    • Nishi, E1    Kume, N2    Ueno, Y3    Ochi, H4    Moriwaki, H5    Kita, T.6
  • 26
    • 0033813079 scopus 로고    scopus 로고
    • Role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis
    • Torzewski M, Rist C, Mortensen RF, Zwaka TP, Bienek M, Waltenberger J, et al. Role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arter Thromb Vasc Biol. 2000;20(9):2094-9.
    • (2000) Arter Thromb Vasc Biol , vol.20 , Issue.9 , pp. 2094-2099
    • Torzewski, M1    Rist, C2    Mortensen, RF3    Zwaka, TP4    Bienek, M5    Waltenberger, J6
  • 27
    • 84859624578 scopus 로고    scopus 로고
    • Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor
    • e3
    • Navarro-Millán I, Singh JA, Curtis JR. Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor. Clin Ther. 2012;34(4):788-802, e3.
    • (2012) Clin Ther , vol.34 , Issue.4 , pp. 788-802
    • Navarro-Millán, I1    Singh, JA2    Curtis, JR.3
  • 28
    • 84871840972 scopus 로고    scopus 로고
    • Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome
    • Izar MC, Fonseca HA, Pinheiro LF, Monteiro CM, Póvoa RM, Monteiro AM, et al. Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome. Diab Vasc Dis Res. 2013;10(1): 32-9.
    • (2013) Diab Vasc Dis Res , vol.10 , Issue.1 , pp. 32-39
    • Izar, MC1    Fonseca, HA2    Pinheiro, LF3    Monteiro, CM4    Póvoa, RM5    Monteiro, AM6
  • 30
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes. Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J, Kroke A, Möhlig M, Hoffmann K, Bergmann MM, Ristow M, et al. Inflammatory cytokines and the risk to develop type 2 diabetes. Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes. 2003;52(3):812-7.
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 812-817
    • Spranger, J1    Kroke, A2    Möhlig, M3    Hoffmann, K4    Bergmann, MM5    Ristow, M6
  • 31
    • 39449139083 scopus 로고    scopus 로고
    • Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
    • Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, et al. Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects. Atherosclerosis. 2008;197(1):271-7.
    • (2008) Atherosclerosis , vol.197 , Issue.1 , pp. 271-277
    • Ruotsalainen, E1    Vauhkonen, I2    Salmenniemi, U3    Pihlajamäki, J4    Punnonen, K5    Kainulainen, S6
  • 32
    • 84883511924 scopus 로고    scopus 로고
    • Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease
    • Suppl 3
    • Imai Y, Dobrian AD, Weaver JR, Butcher MJ, Cole BK, Galkina EV, et al. Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. Diabetes Obes Metab. 2013;15 Suppl 3:117-29.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 117-129
    • Imai, Y1    Dobrian, AD2    Weaver, JR3    Butcher, MJ4    Cole, BK5    Galkina, EV6
  • 33
    • 79955615961 scopus 로고    scopus 로고
    • Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes
    • Maedler K, Dharmadhikari G, Schumann DM, Størling J. Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes. Handb Exp Pharmacol. 2011;203:257-78.
    • (2011) Handb Exp Pharmacol , vol.203 , pp. 257-278
    • Maedler, K1    Dharmadhikari, G2    Schumann, DM3    Størling, J.4
  • 34
    • 79959332548 scopus 로고    scopus 로고
    • Implicaciones fisiopatológicas entre inflamación crónica y el desarrollo de diabetes y obesidad
    • González-Chávez A, Elizondo-Argueta S, Gutiérrez-Reyes G, León-Pedroza JI. Implicaciones fisiopatológicas entre inflamación crónica y el desarrollo de diabetes y obesidad. Cir Cir. 2011;79(2):209-16.
    • (2011) Cir Cir , vol.79 , Issue.2 , pp. 209-216
    • González-Chávez, A1    Elizondo-Argueta, S2    Gutiérrez-Reyes, G3    León-Pedroza, JI.4
  • 36
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091): 87-91.
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, GS1    Shargill, NS2    Spiegelman, BM.3
  • 37
    • 0347423198 scopus 로고    scopus 로고
    • Seventh report of the Joint National Committee on Prevention, Detection Evaluation, and Treatment of High Blood Pressure
    • Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the Joint National Committee on Prevention, Detection Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-52.
    • (2003) Hypertension , vol.42 , Issue.6 , pp. 1206-1252
    • Chobanian, AV1    Bakris, GL2    Black, HR3    Cushman, WC4    Green, LA5    Izzo, JL6
  • 38
    • 0345492466 scopus 로고    scopus 로고
    • C-reactive protein and the risk of developing hypertension
    • Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM. C-reactive protein and the risk of developing hypertension. JAMA. 2003;290(22):2945-51.
    • (2003) JAMA , vol.290 , Issue.22 , pp. 2945-2951
    • Sesso, HD1    Buring, JE2    Rifai, N3    Blake, GJ4    Gaziano, JM5    Ridker, PM.6
  • 39
    • 84946601891 scopus 로고    scopus 로고
    • Soluble receptor for advanced glycation end products levels are associated with asymmetric dimethylarginine and low-grade inflammation in essential hypertension
    • Dimitriadis K, Tsioufis K, Poulakis M, Lioni L, Flessas D, Kintis K, et al. Soluble receptor for advanced glycation end products levels are associated with asymmetric dimethylarginine and low-grade inflammation in essential hypertension. J Am Coll Cardiol. 2011;57(14s1). E1560-E1560.
    • (2011) J Am Coll Cardiol , vol.57 , Issue.14s1 , pp. E1560-E1560
    • Dimitriadis, K1    Tsioufis, K2    Poulakis, M3    Lioni, L4    Flessas, D5    Kintis, K6
  • 40
    • 0348223805 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in angiotensin II-induced vasoconstriction
    • De Groot AA, van Zwieten PA, Peters SLM. Involvement of reactive oxygen species in angiotensin II-induced vasoconstriction. J Cardiovasc Pharmacol. 2004;43(1):154-9.
    • (2004) J Cardiovasc Pharmacol , vol.43 , Issue.1 , pp. 154-159
    • De Groot, AA1    van Zwieten, PA2    Peters, SLM.3
  • 41
    • 67049099210 scopus 로고    scopus 로고
    • Human C-reactive protein and the metabolic syndrome
    • Devaraj S, Singh U, Jialal I. Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol. 2009;20(3):182-9.
    • (2009) Curr Opin Lipidol , vol.20 , Issue.3 , pp. 182-189
    • Devaraj, S1    Singh, U2    Jialal, I.3
  • 42
    • 80054971699 scopus 로고    scopus 로고
    • The relationship between the morning blood pressure surge and low-grade inflammation on silent cerebral infarct and clinical stroke events
    • Shimizu M, Ishikawa J, Yano Y, Hoshide S, Shimada K, Kario K. The relationship between the morning blood pressure surge and low-grade inflammation on silent cerebral infarct and clinical stroke events. Atherosclerosis. 2011;219(1):316-21.
    • (2011) Atherosclerosis , vol.219 , Issue.1 , pp. 316-321
    • Shimizu, M1    Ishikawa, J2    Yano, Y3    Hoshide, S4    Shimada, K5    Kario, K.6
  • 43
    • 34047199319 scopus 로고    scopus 로고
    • Morning blood pressure surge as a destabilizing factor of atherosclerotic plaque: role of ubiquitin-proteasome activity
    • Marfella R, Siniscalchi M, Portoghese M, Di Filippo C, Ferraraccio F, Schiattarella C, et al. Morning blood pressure surge as a destabilizing factor of atherosclerotic plaque: role of ubiquitin-proteasome activity. Hypertension. 2007;49(4): 784-91.
    • (2007) Hypertension , vol.49 , Issue.4 , pp. 784-791
    • Marfella, R1    Siniscalchi, M2    Portoghese, M3    Di Filippo, C4    Ferraraccio, F5    Schiattarella, C6
  • 45
    • 84871947641 scopus 로고    scopus 로고
    • Increased low-grade inflammation is associated with lack of functional response to carvedilol in patients with systolic heart failure
    • Fragasso G, Spoladore R, Maranta F, Corti A, Lattuada G, Colombo B, et al. Increased low-grade inflammation is associated with lack of functional response to carvedilol in patients with systolic heart failure. J Cardiovasc Med (Hagerstown). 2013;14(1):49-56.
    • (2013) J Cardiovasc Med (Hagerstown) , vol.14 , Issue.1 , pp. 49-56
    • Fragasso, G1    Spoladore, R2    Maranta, F3    Corti, A4    Lattuada, G5    Colombo, B6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.