Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

Diabetes and Vascular Disease Research

Volumn 10, Issue 1, 2013, Pages 32-39

  Izar, Maria C ^a,b   Fonseca, Henrique A ^a   Pinheiro, Luiz F ^a   Monteiro, Carlos M ^a   Póvoa, Rui M ^a   Monteiro, Andréa M ^b   Figueiredo Neto, Antonio M ^b   Gidlund, Magnus A ^b   Fonseca, Francisco A ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute coronary syndrome (ACS); autoantibodies (Abs); metabolic syndrome (MetS); oxidized low density lipoprotein (oxLDL)

Indexed keywords

APOLIPOPROTEIN B; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CLOPIDOGREL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; NITRATE; OXIDIZED LOW DENSITY LIPOPROTEIN ANTIBODY; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADAPTIVE IMMUNITY; ADULT; AGED; ANTIBODY TITER; ARTICLE; BLOOD CLOT LYSIS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; DIASTOLIC BLOOD PRESSURE; DISEASE DURATION; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PREVALENCE; PROSPECTIVE STUDY; SCORING SYSTEM; SYSTOLIC BLOOD PRESSURE;

ACUTE CORONARY SYNDROME; ADAPTIVE IMMUNITY; ADULT; AGE FACTORS; AGED; ANGINA, UNSTABLE; AUTOANTIBODIES; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LIPOPROTEINS, LDL; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MYOCARDIAL INFARCTION; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 84871840972     PISSN: 14791641     EISSN: 17528984     Source Type: Journal    
DOI: 10.1177/1479164112443374     Document Type: Article

References (42)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999 ; 340: 115-126
2. Libby P. Vascular biology of atherosclerosis: overview and state of the art. Am J Cardiol. 2003 ; 91: 3A - 6A (Pubitemid 36351456)
3. Frostegard J, Nilsson J, Haegerstrand A, et al. Oxidized low-density lipoprotein induces differentiation and adhesion of linear monocytes and the monocytic cell line U937. Proc Natl Acad Sci USA. 1990 ; 87: 904-908
4. Grundy S. Oxidized LDL and atherogenesis: relation to risk factors for coronary heart disease. Clin Cardiol. 1993 ; 16: 13-15
5. Palinski W, Ord VA, Plump AS, et al. Apo-E-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb. 1994 ; 14: 605-616
6. Svensjo E, Boschcov P, Ketelhuth DF, et al. Increased microvascular permeability in the hamster cheek pouch induced by oxidized low-density lipoprotein (oxLDL) and some fragmented apolipoprotein B proteins. Inflamm Res. 2003 ; 52: 215-220 (Pubitemid 36712966)
7. Ylä-Herttuala S, Palinski W, Rosenfeld ME, et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989 ; 84: 1086-1095 (Pubitemid 19247577)
8. Palinski W, Rosenfeld ME, Ylä-Herttuala S, et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA. 1989 ; 86: 1372-1376 (Pubitemid 19061548)
9. Virella G, Lopes-Virella MF. Lipoprotein autoantibodies: Measurement and significance. Clin Diagn Lab Immunol. 2003 ; 10: 499-505 (Pubitemid 36890428)
10. Nilsson J, Hansson GK. Autoimmunity in atherosclerosis: A protective response losing control?. J Intern Med. 2008 ; 263: 464-478 (Pubitemid 351533555)
11. Shoenfeld Y, Wu R, Dearing LD, et al. Are anti-oxidized low-density lipoprotein antibodies pathogenic or protective?. Circulation. 2004 ; 110: 2552-2558 (Pubitemid 39453000)
12. Zampieri S, Iaccarino L, Ghirardello A, et al. Systemic lupus erythematosus, atherosclerosis, and autoantibodies. Ann N Y Acad Sci. 2005 ; 1051: 351-361 (Pubitemid 41362765)
13. Santos AO, Fonseca FA, Fischer SM, et al. High circulating autoantibodies against human oxidized low-density lipoprotein are related to stable and lower titers to unstable clinical situation. Clin Chim Acta. 2009 ; 406: 113-118
14. Fernandes JL, Orford JL, Garcia C, et al. Differences in human antioxidized LDL autoantbodies in patients with stable and unstable angina. J Autoimmun. 2004 ; 23: 345-352 (Pubitemid 39574809)
15. Lamarche B. Abdominal obesity and its metabolic complications: implications for the risk of ischaemic heart disease. Coron Artery Dis. 1998 ; 9: 473-481 (Pubitemid 28517590)
16. Holvoet P, Lee D, Steffes M, et al. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA. 2008 ; 299: 2287-2293 (Pubitemid 351724395)
17. Antman EM, Cohen M, Bernink PJ, et al. The TIMI risk score for unstable angina / non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA. 2000 ; 284: 835-842 (Pubitemid 30643610)
18. Pollack CV, Antman EM, Hollander JE. American College of Cardiology, American Heart Association, 2007 focused update to the ACC/AHA guidelines for the management of patients with ST-segment elevation myocardial infarction: implications for emergency department practice. Ann Emerg Med. 2008 ; 52: 344-355
19. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. JAMA. 2001 ; 285: 2486-2497
20. Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003 ; 289: 2560-2572
21. Hunt SA. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol. 2005 ; 46: e1 - e82
22. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 ; 18: 499-502
23. Puhl H, Waeg G, Esterbauer H. Methods to determine oxidation of low-density lipoproteins. Methods Enzymol. 1994 ; 233: 425-441
24. Fernvik EC, Ketelhuth DF, Russo M, et al. The autoantibody repertoire against copper- or macrophage-modified LDL differs in normolipidemics and hypercholesterolemic patients. J Clin Immunol. 2004 ; 24: 170-176 (Pubitemid 38457231)
25. Ketelhuth DF, Tonini GC, Carvalho MD, et al. Autoantibody response to chromatographic fractions from oxidized LDL in unstable angina patients and healthy controls. Scand J Immunol. 2008 ; 68: 456-462
26. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol. 1983 ; 51: 606 (Pubitemid 13187192)
27. Zaratin A, Gidlund M, Boschcov P, et al. Antibodies against oxidized low-density lipoprotein in normolipidemic smokers. Am J Cardiol. 2002 ; 90: 651-653 (Pubitemid 35264547)
28. Virella G, Virella I, Leman RB, et al. Anti-oxidized low-density lipoprotein antibodies in patients with coronary heart disease and normal healthy volunteers. Int J Clin Lab Res. 1993 ; 23: 95-101
29. Monteiro AM, Jardini MA, Alves S, et al. Cardiovascular disease parameters in periodontitis. J Periodontol. 2009 ; 80: 378-388
30. Brandao SA, Izar MC, Fischer SC, et al. Early increase in autoantibodies against human oxidized low-density lipoprotein in hypertensive patients after blood pressure control. Am J Hypertens. 2010 ; 23: 208-214
31. Garrido-Sánchez L, Cardona F, García-Fuentes F, et al. Anti-oxidized low-density lipoprotein antibody levels are associated with the development of type 2 diabetes mellitus. Eur J Clin Invest. 2008 ; 38: 615-621
32. George J, Wexler D, Roth A, et al. Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure. Eur J Heart Fail. 2006 ; 8: 58-62 (Pubitemid 43012102)
33. Shoji T, Kimoto E, Shinohara K, et al. The association of antibodies against oxidized low-density lipoprotein with atherosclerosis in hemodialysis patients. Kidney Int Suppl. 2003 ; 84: S128 - S130
34. Wang TC, Hsu CC, Chin YP, et al. The autoantibody expression against different source of oxidized low density lipoprotein in patients with acute myocardial infarction. Thromb Res. 2007 ; 107: 175-179
35. Shaw PX, Hörkkö S, Tsimikas S, et al. Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo. Arterioscler Thromb Vasc Biol. 2001 ; 21: 1333-1339 (Pubitemid 34219841)
36. Lopez D, Kobayashi K, Merrill JT, et al. IgG autoantibodies against β2-glycoprotein I complexed with a lipid ligand derived from oxidized low-density lipoprotein are associated with arterial thrombosis in antiphospholipid syndrome. Clin Dev Immunol. 2003 ; 10: 203-211 (Pubitemid 38089413)
37. Balada E, Ordi-Ros J, Matas L, et al. Atherosclerosis and anti-oxidized low density lipoprotein antibodies in an elderly population. Med Clin (Barc). 2002 ; 119: 161-165 (Pubitemid 34855105)
38. Hansson GK, Nilsson J. Vaccination against atherosclerosis? Induction of atheroprotective immunity. Semin Immunopathol. 2009 ; 31: 95-101
39. Laczik R, Szodoray P, Veres K, et al. Assessment of IgG antibodies to oxidized LDL in patients with acute coronary syndrome. Lupus. 2011 ; 20: 730-735
40. Soltesz P, Veres K, Laczik R, et al. Evaluation of antibodies to oxidized low-density lipoprotein and assessment of C-reactive protein in acute coronary syndrome and stable coronary artery disease. Thromb Haemost. 2007 ; 98: 413-419 (Pubitemid 47250245)
41. Medeiros AM, von Mühlen CA, Gidlund MA, et al. Antibodies against oxLDL and acute coronary syndrome. Arq Bras Cardiol. 2010 ; 95: 47-54
42. Tinahones FJ, Gómez-Zumaquero JM, Garrido-Sánchez L, et al. Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population. J Lipid Res. 2005 ; 46: 452-457 (Pubitemid 43109781)