Ketamine administration diminishes operant responding but does not impair conditioned fear

Pharmacology Biochemistry and Behavior

Volumn 139, Issue , 2015, Pages 84-91

  Groeber Travis, Caitlin M ^a   Altman, Daniel E ^a   Genovese, Raymond F ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Conditioned fear; Conditioned suppression; Ketamine; Operant conditioning; PTSD; Stress processes

Indexed keywords

KETAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSE REGIMEN; EMOTION; FEAR; INSTRUMENTAL CONDITIONING; MALE; MEMORY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; STIMULUS RESPONSE; TASK PERFORMANCE; ANIMAL; DRUG EFFECTS;

ANIMALS; CONDITIONING, OPERANT; EXTINCTION, PSYCHOLOGICAL; FEAR; KETAMINE; MALE; RATS;

EID: 84946118478     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.10.013     Document Type: Article

References (60)

1. P. Amorapanth, K. Nader, and J.E. LeDoux Lesions of periaqueductal gray dissociate-conditioned freezing from conditioned suppression behavior in rats Learn. Mem. 6 1999 491 499
2. R.F. Bell, J.B. Dahl, R.A. Moore, and E. Kalso Perioperative ketamine for acute post-operative pain Cochrane Database Syst. Rev. 1 2006 CD004603
3. R.M. Berman, A. Cappiello, A. Anand, D.A. Oren, G.R. Heninger, D.S. Charney, and J.H. Krystal Antidepressant effects of ketamine in depressed patients Biol. Psychiatry 47 2000 351 354
4. A. Boultadakis, and N. Pitsikas Anesthetic ketamine impairs rats' recall of previous information: the nitric oxide synthase inhibitor N-nitro-l-arginine methylester antagonizes this ketamine-induced recognition memory deficit Anesthesiology 114 2011 1345 1353
5. J. Carter, and D.A. Story Veterinary and human anaesthesia: an overview of some parallels and contrasts Anaesth. Intensive Care 41 2013 710 718
6. S.P. Cohen, and M. DeJesus Ketamine patient-controlled analgesia for dysesthetic central pain Spinal Cord 42 2004 425 428
7. M.L. Cohen, and A.J. Trevor On the cerebral accumulation of ketamine and the relationship between metabolism of the drug and its pharmacological effects J. Pharmacol. Exp. Ther. 189 1974 351 358
8. G.E. Correll, and G.E. Futter Two case studies of patients with major depressive disorder given low-dose (subanesthetic) ketamine infusions Pain Med. 7 2006 92 95
9. H.V. Curran, and C. Morgan Cognitive, dissociative and psychotogenic effects of ketamine in recreational users on the night of drug use and 3 days later Addiction 95 2000 575 590
10. N. Diazgranados, L.A. Ibrahim, N.E. Brutsche, A. Newberg, P. Kronstein, and S. Khalife C.A. Zarate Jr. A randomized add-on trial of an N-methyl-d-aspartate antagonist in treatment-resistant bipolar depression Arch. Gen. Psychiatry 67 2010 793 802
11. A. Dutta, S. McKie, and J.F. Deakin Ketamine and other potential glutamate antidepressants Psychiatry Res. 225 2015 1 13
12. W.K. Estes, and B.F. Skinner Some quantitative properties of anxiety J. Exp. Psychol. 29 1941 290 300
13. A. Feder, M.K. Parides, J.W. Murrough, A.M. Perez, J.E. Morgan, and S. Saxena D.S. Charney Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial JAMA Psychiatry 71 2014 681 688
14. Genovese, R.F., Dobre, S., Groeber Travis, C.M., Johnson, C.C. Effects of ketamine on behavioral changes induced by predator exposure in rats. Presentation No. 842.06. The Society for Neuroscience Annual Meeting, 2014. Washington, DC.
15. R.F. Genovese, L.P. Simmons, S.T. Ahlers, E. Maudlin-Jeronimo, J.R. Dave, and A.M. Boutte Effects of mild TBI from repeated blast overpressure on the expression and extinction of conditioned fear in rats Neuroscience 254 2013 120 129
16. B.K. Goulart, M.N. de Lima, C.B. de Farias, G.K. Reolon, V.R. Almeida, J. Quevedo, and et al. Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels Neuroscience 167 2010 969 973
17. D.A. Haas, and D.G. Harper Ketamine. A review of its pharmacological properties and use in ambulatory anesthesia Anesth. Prog. 39 1992 61 68
18. D-aspartate receptors Brain Res. 323 1984 132 137
19. M.J. Honsberger, J.R. Taylor, and P.R. Corlett Memories reactivated under ketamine are subsequently stronger: a potential pre-clinical behavioral model of psychosis Schizophr. Res. 164 2015 227 233
20. A. Jackson, and D.J. Sanger Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-d-aspartate Neuropsychopharmacology 28 1989 459 464
21. J. Jouguelet-Lacoste, L. La Colla, D. Schilling, and J.E. Chelly The use of intravenous infusion or single dose of low-dose ketamine for postoperative analgesia: a review of current literature Pain Med. 16 2015 383 403
22. R. Kohrs, and M.E. Durieux Ketamine: teaching an old drug new tricks Anesth. Analg. 87 1998 1186 1193
23. J.J. Krystal, L.P. Karper, J.P. Seibyl, G.K. Freeman, R. Delaney, J.D. Bremner, and et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in human. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses Arch. Gen. Psychiatry 51 1994 199 214
24. G.L. Larkin, and A.L. Beautrais A preliminary naturalistic study of low-dose ketamine for depression and suicidal ideation in the emergency department Int. J. Neuropsychopharmacol. 14 2011 1127 1131
25. J.L.C. Lee, A. Dickinson, and B.J. Everitt Conditioned suppression and freezing as measures of aversive Pavlovian conditioning: effects of discrete amygdala lesions and overtraining Behav. Brain Res. 159 2005 221 233
26. H. Liu, G.-H. Xu, K. Wang, J.-L. Cao, E.-W. Gu, Y.-H. Li, and X.-S. Liu Involvement of GSK3β/β-catenin signaling in the impairment effect of ketamine on spatial memory consolidation in rats Neurobiol. Learn. Mem. 111 2014 26 34
27. M.A. McDannald Contributions of the amygdale central nucleus and ventrolateral periaqueductal grey to freezing and instrumental suppression in Pavlovian fear conditioning Behav. Brain Res. 211 2010 111 117
28. M.A. McDannald, and E.M. Galarce Measuring Pavlovian fear with conditioned freezing and conditioned suppression reveals different roles for the basolateral amygdala Behav. Brain Res. 1374 2011 82 89
29. J.L. McGaugh Memory - a century of consolidation Science 287 2000 248 251
30. G.A. Mickley, J.D. Lovelace, S.T. Farrell, and K.S. Chang The intensity of a festal taste aversion is modulated by the anesthesia used during conditioning Dev. Brain Res. 85 1995 119 127
31. G.A. Mickley, D.R. Remmers-Roeber, C.M. Dengler, C.A. McMullen, C.L. Kenmuir, B. Girdler, C. Crouse, and C. Walker Simple behavioral methods to assess the effect of drugs or toxins on sensory experience J. Neurosci. Methods 115 2002 85 92
32. G.A. Mickley, M.A. Schaldach, K.J. Snyder, S.A. Balogh, T. Len, K. Neimanis, P. Goulis, and et al. Ketamine blocks a conditioned taste aversion (CTA) in neonate rats Physiol. Behav. 64 1998 381 390
33. N.L. Moore, S. Gauchan, and R.F. Genovese Adolescent traumatic stress experience results in less robust conditioned fear and post-extinction fear cue responses in adult rats Pharmacol. Biochem. Behav. 120 2014 17 24
34. M. Moosavi, G.Y. Khales, K. Rastegar, and A. Zarifkar The effects of sub-anesthetic and anesthetic ketamine on water maze memory acquisition, consolidation and retrieval Eur. J. Pharmacol. 677 2012 107 110
35. C.J.A. Morgan, L. Muetzelfeldt, and H.V. Curran Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls Addiction 104 2009 77 87
36. J.W. Murrough, A.M. Perez, S. Pillemer, J. Stern, M.K. Parides, M. aan het Rot, and et al. Rapid and longer-term antidepressant effects of repeated ketamine infusions treatment-resistant major depression Biol. Psychiatry 74 2013 250 256
37. J.W. Newcomer, N.B. Farber, V. Jevtovic-Todorovic, G. Selke, A.K. Melson, A.K. Hershey, S. Craft, and J.W. Olney Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis Neuropsychopharmacology 20 1999 106 118
38. A. Parwani, M.A. Weiler, T.A. Blaxton, D. Warfel, M. Hardin, K. Frey, and A.C. Lahti The effects of a subanesthetic dose of ketamine on verbal memory in humans Psychopharmacology 183 2005 265 274
39. A. Perugini, M. Laing, N. Berretta, G. Aicardi, and Z.I. Bashir Synaptic plasticity from amygdala to perirhinal cortex: a possible mechanism for emotional enhancement of visual recognition memory? Eur. J. Neurosci. 36 2012 2421 2427
40. C.L. Pickens, B.M. Navarre, and S.G. Nair Incubation of conditioned fear in the conditioned suppression model in rats: role of food restriction conditions, length of conditioned stimulus, and generality to conditioned freezing Neuroscience 169 2010 1501 1510
41. C.Y. Pietersen, F.J. Bosker, F. Postema, D.S. Fokkema, J. Korf, and J.A. den Boer Ketamine administration disturbs behavioral and distributed neural correlates of fear conditioning in the rat Prog. Neuro-Psychopharmacol. Biol. Psychiatry 30 2006 1209 1218
42. N. Pitsikas, and A. Boultadakis Pre-training administration of anesthetic ketamine differentially affects rats' spatial and non-spatial recognition memory Neuropharmacology 57 2009 1 7
43. A. Plunkett, A. Turabi, and I. Wilkinson Battlefield analgesia: a brief review of current trends and concepts in the treatment of pain in the US military casualties from the conflicts in Iraq and Afghanistan Pain Manag. 2 2012 231 238
44. R.B. Price, M.T. Nock, D.S. Charney, and S.J. Mathew Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression Biol. Psychiatry 66 2009 522 526
45. T.W. Puetz, S.D. Youngstedt, and M.P. Herring Effects of pharmacotherapy on combat-related PTSD, anxiety, and depression: a systematic review and meta-regression analysis PLoS One 10 2015 1 18
46. V. Rau, J.P. DeCola, and M.S. Fanselow Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder Defensive Behav. 29 2005 1207 1223
47. P. Richardson, and L. Mustard The management of pain in the burns unit Burns 35 2009 921 936
48. E. Santini, R.U. Muller, and G.J. Quirk Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory J. Neurosci. 21 2001 9009 9017
49. C.L. Shaffer, S.M. Osgood, D.L. Smith, J. Liu, and P.E. Trapa Enhancing ketamine translational pharmacology via receptor occupancy normalization Neuropharmacology 86 2014 174 180
50. C.R. Schuster, W.S. Dockens, and J.H. Woods Behavioral variables affecting the development of amphetamine tolerance Psychopharmacologia 9 1966 170 182
51. M. Shimoyama, N. Shimoyama, A.L. Gorman, K.J. Elliott, and C.E. Inturrisi Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine Pain 81 1999 85 93
52. A.B. Storsve, G.P. McNally, and R. Richardson US habituation, like CS extinction, produces a decrement in conditioned fear responding that is NMDA depended and subject to renewal and reinstatement Neurobiol. Learn. Mem. 93 2010 463 471
53. D. Veilleux-Lemieux, A. Castel, D. Carrier, F. Beaudry, and P. Vachon Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats J. Am. Assoc. Lab. Anim. Sci. 52 2013 567 570
54. D-aspartate receptors Brain Res. 1621 2015 5 16
55. J.H. Wang, Y. Fu, F.A.W. Wilson, and Y.Y. Ma Ketamine affects memory consolidation: differential effects in T-maze and passive avoidance paradigms in mice Neuroscience 140 2006 993 1002
56. H. Welzl, B. Alessandri, and K. Battig The formation of a new gustatory memory trace in rats is prevented by the noncompetitive NMDA antagonist ketamine Psychobiology 18 1990 43 47
57. P.F. White, R.R. Johnston, and C.R. Pudwill Interaction of ketamine and halothane in rats Anesthesiology 42 1975 179 186
58. P.F. White, M.P. Marietta, C.R. Pudwill, W.L. Way, and A.J. Trevor Effects of halothane anesthesia on the biodisposition of ketamine in rats J. Pharmacol. Exp. Ther. 196 1976 545 555
59. P.F. White, W.L. Way, and A.J. Trevor Ketamine - its pharmacology and therapeutic uses Anesthesiology 56 1982 119 136
60. C.A. Zarate Jr., J.B. Singh, P.J. Carlson, N.E. Brutsche, R. Ameli, D.A. Luckenbaugh, D.S. Charney, and H.K. Manji A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression Arch. Gen. Psychiatry 63 2006 856 864