Effects of pharmacotherapy on combat-related PTSD, anxiety, and depression: A systematic review and meta-regression analysis

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Puetz, Timothy W ^a   Youngstedt, Shawn D ^b,c,d   Herring, Matthew P ^e  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

^d CARL T HAYDEN VA MEDICAL CENTER   (United States)

^e UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; NEUROLEPTIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ANXIETY DISORDER; ARTICLE; DEPRESSION; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; EFFECT SIZE; HUMAN; META ANALYSIS; PATIENT COMPLIANCE; POSTTRAUMATIC STRESS DISORDER; PSYCHOPHARMACOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SOLDIER; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; VETERAN; ANXIETY; COMBAT DISORDERS; FEMALE; MALE; STRESS DISORDERS, POST-TRAUMATIC;

ANTIDEPRESSIVE AGENTS, TRICYCLIC; ANXIETY; COMBAT DISORDERS; DEPRESSION; FEMALE; HUMANS; MALE; STRESS DISORDERS, POST-TRAUMATIC; VETERANS;

EID: 84934989780     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126529     Document Type: Article

References (45)

1. th ed. Arlington, VA: American Psychiatric Press.
2. Smith T, Ryan MA, Wingard DL, Slymen DJ, Sallis JF, Kritz-Silverstein D, et al. (2008) New onset and persistent symptoms of post-traumatic stress disorder self reported after deployment and combat exposures: Prospective population based US military cohort study. BMJ. 2008; 336(7640): 366-371. doi: 10.1136/bmj.39430.638241.AE PMID: 18198395
3. Richardson LK, Frueh BC, Acierno R. Prevalence estimates of combat-related PTSD: A critical review. Aust N Z J Psychiatry. 2010; 44(1): 4-19. doi: 10.3109/00048670903393597 PMID: 20073563
4. United States Census Bureau. Veteran Status: 2012 American Community Survey 1-Year Estimates. 2012 American Community Survey. U.S. Census Bureau website. Available: http://factfinder2.census.gov. Accessed 31 December 2013.
5. Defense Manpower Data Center, Department of Defense. Contingency Tracking System: Deployment File Baseline Report, as of July 11, 2012.
6. nd Qtr FY 2013. Washington, DC: Author; 2013.
7. IOM (Institute of Medicine). Treatment for posttraumatic stress disorder in military and veteran populations: Final assessment. Washington, DC: The National Academies Press; 2014.
8. Mohamed S, Rosenheck RA. Pharmacotherapy of PTSD in the U.S. Department of Veterans Affairs: diagnostic- and symptom-guided drug selection. J Clin Psychiatry. 2008; 69(6): 959-65. PMID: 18588361
9. Steckler T, Risbrough V. Pharmacological treatment of PTSD-Established and new approaches. Neuropharmacol. 2012; 62(2): 617-627. doi: 10.1016/j.neuropharm.2011.06.012 PMID: 21736888
10. Stein MB, Kline NA, Matloff JL. Adjunctive olanzapine for SSRI-resistant combat-related PTSD: A double-blind, placebo-controlled study. Am J Psychiatry. 2002; 159(10): 1777-1779. PMID: 12359687
11. Kulka RA, Schelenger WE, Fairbank JA, Hough RL, Jordan BK, Marmar CR, et al. Trauma and the Vietnam War generation: Report of findings from the National Vietnam Veterans Readjustment Study. New York, NY: Brunner/Mazel; 1990.
12. Ahearn EP, Juergens T, Cordes T, Becker T, Krahn D. A review of atypical antipsychotic medications for posttraumatic stress disorder. Int Clin Psychopharmacol. 2011; 26(4): 193-200. doi: 10.1097/YIC.0b013e3283473738 PMID: 21597381
13. Berger W, Mendlowicz MV, Marques-Portella C, Kinrys G, Fontenelle LF, Marmar CR, et al. Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: A systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33(2): 169-180. doi: 10.1016/j.pnpbp.2008.12.004 PMID: 19141307
14. Stewart CL, Wrobel TA. Evaluation of the efficacy of pharmacotherapy and psychotherapy in treatment of combat-related post-traumatic stress disorder: A meta-analytic review of outcome studies. Mil Med. 2009; 174(5): 460-469. PMID: 20731275
15. Moher D, Liberati A, Tetzlaff J, Altman DG, Antes G, Atkins D, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann Internal Med. 2009; 151(4): 264-269. PMID: 19622511
16. Herring MP, O'Connor PJ, Dishman RK. The effect of exercise training on anxiety symptoms among patients. A systematic review. Arch Intern Med. 2010; 170(4): 321-331. doi: 10.1001/archinternmed.2009.530 PMID: 20177034
17. Herring MP, Puetz TW, O'Connor PJ, Dishman RK. Effect of exercise training on depressive symptoms among patients with a chronic illness. A systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2012; 172(2): 101-111. doi: 10.1001/archinternmed.2011.696 PMID: 22271118
18. Puetz TW, Herring MP. Differential effects of exercise on cancer-related fatigue during and following treatment. A meta-analysis. Am J Prev Med. 2012; 43(2): e1-e24. doi: 10.1016/j.amepre.2012.04.027 PMID: 22813691
19. Puetz TW, Morley CA, Herring MP. Effects of creative arts therapies on psychological symptoms and quality of life in patients with cancer. JAMA Intern Med. 2013173(11): 960-969.
20. Betthauser LM, Bahraini N, Krengel MH, Brenner LA. Self-report measures to identify post-traumatic stress disorder and/or mild traumatic brain injury and associated symptoms in military veterans of Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF). Neuropsychol Rev. 2012; 22(1): 35-53. doi: 10.1007/s11065-012-9191-4 PMID: 22350740
21. Hedges LV, Olkin I. Statistical Methods for Meta-analysis. New York, NY: Academic Press; 1985.
22. Monnelly DP, Ciraul DA, Knapp C, Keane T. Low-dose risperidone as adjunctive therapy for irritable aggression in Posttraumatic Stress Disorder. J Clin Psychopharmacol. 2003; 23(2): 193-196. PMID: 12640221
23. Rosenthal R. Meta-analytic Procedures for Social Research. London, England: Sage Publications; 1991.
24. Schnurr PP, Friedman MJ, Foy DW, Shea MT, Hsieh FY, Lavori PW, et al. Randomized trial of trauma-focused group therapy for Posttraumatic Stress Disorder. Results from a department of veterans affairs cooperative study. Arch Gen Psychiatry. 2003; 60: 481-489. PMID: 12742869
25. Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbe KA. Incorporating variations in the quality of individual randomized trials into meta-analysis. J Clin Epidemiol. 1992; 43: 255-265.
26. Jüni P, Witschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trials for meta-analysis. JAMA. 1999; 282(11): 1054-60. PMID: 10493204
27. Lipsey MW, Wilson DB. Practical Meta-analysis. Newbury Park, CA: Sage; 2001.
28. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414): 557-60. PMID: 12958120
29. Egger M, Davey-Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109): 629-34. PMID: 9310563
30. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994; 50(4): 1088-1101. PMID: 7786990
31. Gleser LJ, Olkin I. Stochastically dependent effect sizes. In: Cooper H, Hedges LV, eds. The Handbook of Research Synthesis. New York, NY: Sage; pp. 339-55; 1994.
32. Preacher KJ, Curran PJ, Bauer DJ. Computational tools for probing interactions in multiple linear regression, multilevel modeling, and latent curve analysis. J Educ Behav Stat. 2006; 31(4): 437-48.
33. Lazar AA, Zerbe GO. Solution for determining the significance region using the Johnson-Neyman type procedure in generalized linear (mixed) models. J Educ Behav Stat. 2001; 36(6): 699-719.
34. Stein DJ, Ipser J, McAnda N. Pharmacotherapy of posttraumatic stress disorder: A review of meta-analyses and treatment guidelines. CNS Spectr. 2009; 14:1(Suppl 1): 25-31.
35. Ipser JC, Stein DJ. Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD). Int J Neuropsychopharmacol. 2012; 15: 825-840. doi: 10.1017/S1461145711001209 PMID: 21798109
36. Baldwin D, Woods R, Lawson R, Taylor D. Efficacy of drug treatments for generalised anxiety disorder: Systematic review and meta-analysis. BMJ. 2001; 342: d1199.
37. Cook RJ, Sackett DL. The number needed to treat: A clinically useful measure of treatment effect. BMJ. 1995; 310(6977): 452-54. PMID: 7873954
38. Krystal JH, Neumeister A. Noradrenergic and serotonergic mechanisms in the neurobiology of post-traumatic stress disorder and resilience. Brain Res. 2009; 1293: 13-23. doi: 10.1016/j.brainres.2009.03.044 PMID: 19332037
39. Celik C, Ozdemir B, Ozmenler KN, Yelboga Z, Balikci A, Doruk A, et al. Efficacy of paroxetine and amitriptyline in combat related posttraumatic stress disorder: An open-label comparative study. Bull Clin Psychopharmacol. 2011; 21(3): 179-85.
40. O'Donnell ML, Creamer M, Pattison P. Posttraumatic stress disorder and depression following trauma: Understanding Comorbidity. Am J Psychiatry. 2004; 161(8): 1390-1396. PMID: 15285964
41. Blanchard EB, Buckley TC, Hickling EJ, Taylor AE. Posttraumatic stress disorder and comorbid major depression: Is the correlation an illusion? J Anxiety Disord. 1998; 12(1): 21-37. PMID: 9549607
42. Erickson DJ, Wolfe J, King DW, King LA, Sharkansky EJ. Posttraumatic stress disorder and depression symptomatology in a sample of Gulf War veterans: a prospective analysis. J Consult Clin Psychol. 2001; 69(1): 41-9. PMID: 11302276
43. Hidalgo RB, Davidson JRT. Selective serotonin reuptake inhibitors in post-traumatic stress disorder. J Psychopharmacol. 2000; 14(1): 70-76. PMID: 10757257
44. Asnis GM, Kohn SR, Henderson M, Brown NL. SSRIs versus non-SSRIs in post-traumatic stress disorder. An update with recommendations. Drugs. 2004; 64(4): 383-404. PMID: 14969574
45. Campbell DG, Felker BL, Liu CF, Yano EM, Kirchner JE, Chan D, et al. Prevalence of depression-PTSD comorbidity: Implications for clinical practice guidelines and primary care-based interventions. J Gen Intern Med. 2007; 22(6): 711-718. PMID: 17503104