-
1
-
-
67650445156
-
Toxicology for the twenty-first century
-
Hartung,T. (2009) Toxicology for the twenty-first century. Nature, 460, 208-212.
-
(2009)
Nature
, vol.460
, pp. 208-212
-
-
Hartung, T.1
-
2
-
-
37449019721
-
Value of rodent carcinogenesis bioassays
-
Ward,J.M. (2008) Value of rodent carcinogenesis bioassays. Toxicol. Appl. Pharmacol., 226, 212.
-
(2008)
Toxicol. Appl. Pharmacol.
, vol.226
, pp. 212
-
-
Ward, J.M.1
-
3
-
-
26944448621
-
Which drugs cause cancer?
-
Knight,A. et al. (2005) Which drugs cause cancer? For. BMJ, 331, E389-E391.
-
(2005)
For. BMJ
, vol.331
-
-
Knight, A.1
-
4
-
-
33645561835
-
Animal carcinogenicity studies: implications for the REACH system
-
Knight,A. et al. (2006) Animal carcinogenicity studies: implications for the REACH system. Altern. Lab. Anim., 34 (suppl. 1), 139-147.
-
(2006)
Altern. Lab. Anim.
, vol.34
, Issue.SUPPL. 1
, pp. 139-147
-
-
Knight, A.1
-
5
-
-
84861138534
-
QSAR and QM/MM approaches applied to drug metabolism prediction
-
Braga,R.C. et al. (2012) QSAR and QM/MM approaches applied to drug metabolism prediction. Mini Rev. Med. Chem., 12, 573-582.
-
(2012)
Mini Rev. Med. Chem.
, vol.12
, pp. 573-582
-
-
Braga, R.C.1
-
6
-
-
84860663501
-
An overview of values for the threshold of toxicological concern
-
Hennes,E.C. (2012) An overview of values for the threshold of toxicological concern. Toxicol. Lett., 211, 296-303.
-
(2012)
Toxicol. Lett.
, vol.211
, pp. 296-303
-
-
Hennes, E.C.1
-
7
-
-
3242791873
-
Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling
-
van Delft,J.H. et al. (2004) Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling. Carcinogenesis, 25, 1265-1276.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1265-1276
-
-
van Delft, J.H.1
-
8
-
-
19644365314
-
Comparison of supervised clustering methods to discriminate genotoxic from non-genotoxic carcinogens by gene expression profiling
-
van Delft,J.H. et al. (2005) Comparison of supervised clustering methods to discriminate genotoxic from non-genotoxic carcinogens by gene expression profiling. Mutat. Res., 575, 17-33.
-
(2005)
Mutat. Res.
, vol.575
, pp. 17-33
-
-
van Delft, J.H.1
-
9
-
-
61449164867
-
Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
-
Ellinger-Ziegelbauer,H. et al. (2009) Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity. Toxicol. Lett., 186, 36-44.
-
(2009)
Toxicol. Lett.
, vol.186
, pp. 36-44
-
-
Ellinger-Ziegelbauer, H.1
-
10
-
-
2142825650
-
Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins
-
Hu,T. et al. (2004) Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins. Mutat. Res., 549, 5-27.
-
(2004)
Mutat. Res.
, vol.549
, pp. 5-27
-
-
Hu, T.1
-
11
-
-
34247128690
-
Characterization of DNA reactive and non- DNA reactive anticancer drugs by gene expression profiling
-
Le Fevre,A.C. et al. (2007) Characterization of DNA reactive and non- DNA reactive anticancer drugs by gene expression profiling. Mutat. Res., 619, 16-29.
-
(2007)
Mutat. Res.
, vol.619
, pp. 16-29
-
-
Le Fevre, A.C.1
-
12
-
-
34548382555
-
Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals
-
Li,H.H. et al. (2007) Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals. Mutat. Res., 623, 98-108.
-
(2007)
Mutat. Res.
, vol.623
, pp. 98-108
-
-
Li, H.H.1
-
13
-
-
78149369706
-
Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds
-
Mathijs,K. et al. (2010) Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds. Mutagenesis, 25, 561-568.
-
(2010)
Mutagenesis
, vol.25
, pp. 561-568
-
-
Mathijs, K.1
-
14
-
-
33748302750
-
Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells
-
Tsujimura,K. et al. (2006) Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells. Cancer Sci., 97, 1002-1010.
-
(2006)
Cancer Sci.
, vol.97
, pp. 1002-1010
-
-
Tsujimura, K.1
-
15
-
-
84865188988
-
A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo
-
Magkoufopoulou,C. et al. (2012) A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis, 33, 1421-1429.
-
(2012)
Carcinogenesis
, vol.33
, pp. 1421-1429
-
-
Magkoufopoulou, C.1
-
16
-
-
33749335282
-
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb,J. et al. (2006) The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science, 313, 1929-1935.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
-
17
-
-
84870326718
-
Applications of Connectivity Map in drug discovery and development
-
Qu,X.A. et al. (2012) Applications of Connectivity Map in drug discovery and development. Drug Discov. Today, 17, 1289-1298.
-
(2012)
Drug Discov. Today
, vol.17
, pp. 1289-1298
-
-
Qu, X.A.1
-
18
-
-
33747830764
-
Hepatocellular carcinoma pathogenesis: from genes to environment
-
Farazi,P.A. et al. (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer, 6, 674-687.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 674-687
-
-
Farazi, P.A.1
-
19
-
-
50649089207
-
RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays
-
Marioni,J.C. et al. (2008) RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays. Genome Res., 18, 1509-1517.
-
(2008)
Genome Res.
, vol.18
, pp. 1509-1517
-
-
Marioni, J.C.1
-
20
-
-
78649445529
-
A comparative analysis of liver transcriptome suggests divergent liver function among human, mouse and rat
-
Yu,Y. et al. (2010) A comparative analysis of liver transcriptome suggests divergent liver function among human, mouse and rat. Genomics, 96, 281-289.
-
(2010)
Genomics
, vol.96
, pp. 281-289
-
-
Yu, Y.1
-
21
-
-
70449571951
-
Comprehensive gene and microRNA expression profiling reveals a role for microRNAs in human liver development
-
Tzur,G. et al. (2009) Comprehensive gene and microRNA expression profiling reveals a role for microRNAs in human liver development. PLoS One, 4, e7511.
-
(2009)
PLoS One
, vol.4
-
-
Tzur, G.1
-
22
-
-
80052356895
-
Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database
-
Uehara,T. et al. (2011) Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database. Toxicol. Appl. Pharmacol., 255, 297-306.
-
(2011)
Toxicol. Appl. Pharmacol.
, vol.255
, pp. 297-306
-
-
Uehara, T.1
-
23
-
-
69449085763
-
sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures
-
Zhang,S.D. et al. (2009) sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures. BMC Bioinformatics, 10, 236.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 236
-
-
Zhang, S.D.1
-
24
-
-
34748920495
-
Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online)
-
Hsu,C.N. et al. (2007) Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online). BMC Bioinformatics, 8, 66.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 66
-
-
Hsu, C.N.1
-
25
-
-
0038786861
-
Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma
-
Capurro,M. et al. (2003) Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology, 125, 89-97.
-
(2003)
Gastroenterology
, vol.125
, pp. 89-97
-
-
Capurro, M.1
-
26
-
-
41649107645
-
Analysis of the mechanisms mediating tumorspecific changes in gene expression in human liver tumors
-
Acevedo,L.G. et al. (2008) Analysis of the mechanisms mediating tumorspecific changes in gene expression in human liver tumors. Cancer Res., 68, 2641-2651.
-
(2008)
Cancer Res.
, vol.68
, pp. 2641-2651
-
-
Acevedo, L.G.1
-
27
-
-
77957833984
-
Cancer biomarkers: can we turn recent failures into success?
-
Diamandis,E.P. (2010) Cancer biomarkers: can we turn recent failures into success? J. Natl Cancer Inst., 102, 1462-1467.
-
(2010)
J. Natl Cancer Inst.
, vol.102
, pp. 1462-1467
-
-
Diamandis, E.P.1
-
28
-
-
13444283596
-
Bias as a threat to the validity of cancer molecularmarker research
-
Ransohoff,D.F. (2005) Bias as a threat to the validity of cancer molecularmarker research. Nat. Rev. Cancer, 5, 142-149.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 142-149
-
-
Ransohoff, D.F.1
|