Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion

Toxicology in Vitro

Volumn 23, Issue 3, 2009, Pages 486-499

  Jennings, Paul ^a   Aydin, Sonia ^a   Bennett, Jason ^b   McBride, Rachael ^b   Weiland, Christina ^c   Tuite, Niamh ^b   Gruber, Leonhard N ^a   Perco, Paul ^e   Gaora, Peadar Ó ^b   Ellinger Ziegelbauer, Heidrun ^c   Ahr, Hans Juergen ^c   Kooten, Cees Van ^d   Daha, Mohamed R ^d   Prieto, Pilar ^f   Ryan, Michael P ^b   Pfaller, Walter ^a   McMorrow, Tara ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c BAYER PHARMA AG   (Germany)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF VIENNA   (Austria)

^f JOINT RESEARCH CENTRE   (Italy)

Author keywords

Cell culture medium; CsA; Cyclosporine A; DNA microarray; Epithelial; Glucose; HK 2; Lactate; Proximal tubule; Renal; Transcriptomics

Indexed keywords

CYCLOSPORIN A; GLYCOPROTEIN GP 96; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN B9; HEAT SHOCK PROTEIN C10; HEAT SHOCK PROTEIN C3; PROTEIN DNAJ; PROTEIN P53; TRANSCRIPTOME; UNCLASSIFIED DRUG; WNT PROTEIN;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA METABOLISM; DNA REPLICATION; DRUG EXPOSURE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMETHOD COMPARISON; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MICROARRAY ANALYSIS; MITOSIS; REPRODUCIBILITY; RNA HYBRIDIZATION; RNA ISOLATION; TOXICITY TESTING;

ANIMAL TESTING ALTERNATIVES; CELL LINE; CLUSTER ANALYSIS; CYCLOSPORINE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TUBULES, PROXIMAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER;

EID: 60849138779     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.12.023     Document Type: Article

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