Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1855-1862

  Limonciel, Alice ^a   Aschauer, Lydia ^a   Wilmes, Anja ^a   Prajczer, Sinikka ^a   Leonard, Martin O ^b   Pfaller, Walter ^a   Jennings, Paul ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

BALB 3T3; Cell culture; Cell stress; HepaRG; Lactate; Oxidative stress; RPTEC TERT1; Toxicity

Indexed keywords

AMIODARONE; BIOLOGICAL MARKER; BUFLOMEDIL; CADMIUM CHLORIDE; CEFALORIDINE; CIDOFOVIR; CYCLOSPORIN A; DICLOFENAC; LACTIC ACID; TROGLITAZONE;

ANIMAL CELL; ARTICLE; CARBOHYDRATE SYNTHESIS; CELL DEATH; CELL STRESS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOSE CALCULATION; DOSE TIME EFFECT RELATION; DRUG EXPOSURE; FIBROBLAST; GLYCOLYSIS; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY TUBULE CELL; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; REPEATED DRUG DOSE;

3T3 CELLS; ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL MARKERS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG TOXICITY; HUMANS; LACTIC ACID; MICE; TOXICITY TESTS;

EID: 82655174039     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.05.018     Document Type: Article

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