메뉴 건너뛰기




Volumn 8, Issue 11, 2015, Pages 1093-1101

PAK1 promotes intestinal tumor initiation

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AZOXYMETHANE; BETA CATENIN; CYCLIN D1; DEXTRAN SULFATE; MYC PROTEIN; P21 ACTIVATED KINASE 1; PROTEIN KINASE B; WNT PROTEIN; DEXTRAN; MESALAZINE; P21 ACTIVATED KINASE; PAK1 PROTEIN, MOUSE;

EID: 84946111149     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-15-0205-T     Document Type: Article
Times cited : (13)

References (42)
  • 1
    • 79955564023 scopus 로고    scopus 로고
    • Intestinal inflammation and cancer
    • Ullman TA, Itzkowitz SH. Intestinal inflammation and cancer. Gastroenterology 2011;140:1807-16.
    • (2011) Gastroenterology , vol.140 , pp. 1807-1816
    • Ullman, T.A.1    Itzkowitz, S.H.2
  • 2
    • 21344446543 scopus 로고    scopus 로고
    • Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: A systematic review and metaanalysis of observational studies
    • Velayos FS, Terdiman JP, Walsh JM. Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am J Gastroenterol 2005;100:1345-53.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1345-1353
    • Velayos, F.S.1    Terdiman, J.P.2    Walsh, J.M.3
  • 3
    • 84887000015 scopus 로고    scopus 로고
    • The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARgamma
    • Rousseaux C, El-Jamal N, Fumery M, Dubuquoy C, Romano O, Chatelain D, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARgamma. Carcinogenesis 2013;34:2580-6.
    • (2013) Carcinogenesis , vol.34 , pp. 2580-2586
    • Rousseaux, C.1    El-Jamal, N.2    Fumery, M.3    Dubuquoy, C.4    Romano, O.5    Chatelain, D.6
  • 4
    • 72949095645 scopus 로고    scopus 로고
    • Systematic review: Molecular chemoprevention of colorectal malignancy by mesalazine
    • Lyakhovich A, Gasche C. Systematic review: molecular chemoprevention of colorectal malignancy by mesalazine. Aliment Pharmacol Ther 2010;31:202-9.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 202-209
    • Lyakhovich, A.1    Gasche, C.2
  • 5
    • 84884538411 scopus 로고    scopus 로고
    • Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells
    • Managlia E, Katzman RB, Brown JB, Barrett TA. Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells. Inflamm Bowel Dis 2013;19:2051-60.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2051-2060
    • Managlia, E.1    Katzman, R.B.2    Brown, J.B.3    Barrett, T.A.4
  • 6
    • 33846231453 scopus 로고    scopus 로고
    • 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint
    • Luciani MG, Campregher C, Fortune JM, Kunkel TA, Gasche C. 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. Gastroenterology 2007;132:221-35.
    • (2007) Gastroenterology , vol.132 , pp. 221-235
    • Luciani, M.G.1    Campregher, C.2    Fortune, J.M.3    Kunkel, T.A.4    Gasche, C.5
  • 7
    • 75149198407 scopus 로고    scopus 로고
    • Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis
    • e1-3
    • Brown JB, Lee G, Managlia E, Grimm GR, Dirisina R, Goretsky T, et al. Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology 2010;138:595-605, e1-3.
    • (2010) Gastroenterology , vol.138 , pp. 595-605
    • Brown, J.B.1    Lee, G.2    Managlia, E.3    Grimm, G.R.4    Dirisina, R.5    Goretsky, T.6
  • 8
    • 33645101399 scopus 로고    scopus 로고
    • A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon
    • Kim H, Jeon H, Kong H, Yang Y, Choi B, Kim YM, et al. A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon. Mol Pharmacol 2006;69:1405-12.
    • (2006) Mol Pharmacol , vol.69 , pp. 1405-1412
    • Kim, H.1    Jeon, H.2    Kong, H.3    Yang, Y.4    Choi, B.5    Kim, Y.M.6
  • 9
    • 84892366425 scopus 로고    scopus 로고
    • Modulation of N-glycosylation by mesalamine facilitates membranous Ecadherin expression in colon epithelial cells
    • Khare V, Lang M, Dammann K, Campregher C, Lyakhovich A, Gasche C. Modulation of N-glycosylation by mesalamine facilitates membranous Ecadherin expression in colon epithelial cells. Biochem Pharmacol 2014;87:312-20.
    • (2014) Biochem Pharmacol , vol.87 , pp. 312-320
    • Khare, V.1    Lang, M.2    Dammann, K.3    Campregher, C.4    Lyakhovich, A.5    Gasche, C.6
  • 10
    • 84872026149 scopus 로고    scopus 로고
    • Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1
    • Khare V, Lyakhovich A, Dammann K, Lang M, Borgmann M, Tichy B, et al. Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochem Pharmacol 2013;85:234-44.
    • (2013) Biochem Pharmacol , vol.85 , pp. 234-244
    • Khare, V.1    Lyakhovich, A.2    Dammann, K.3    Lang, M.4    Borgmann, M.5    Tichy, B.6
  • 11
    • 84863968373 scopus 로고    scopus 로고
    • Molecular pathways: Targeting p21-activated kinase 1 signaling in cancer-opportunities, challenges, and limitations
    • Eswaran J, Li DQ, Shah A, Kumar R. Molecular pathways: targeting p21-activated kinase 1 signaling in cancer-opportunities, challenges, and limitations. Clin Cancer Res 2012;18:3743-9.
    • (2012) Clin Cancer Res , vol.18 , pp. 3743-3749
    • Eswaran, J.1    Li, D.Q.2    Shah, A.3    Kumar, R.4
  • 12
    • 84902292389 scopus 로고    scopus 로고
    • Tracing PAKs from GI inflammation to cancer
    • Dammann K, Khare V, Gasche C. Tracing PAKs from GI inflammation to cancer. Gut 2014;63:1173-84.
    • (2014) Gut , vol.63 , pp. 1173-1184
    • Dammann, K.1    Khare, V.2    Gasche, C.3
  • 13
    • 84857364721 scopus 로고    scopus 로고
    • A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells
    • Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, et al. A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells. Oncogene 2012;31:1001-12.
    • (2012) Oncogene , vol.31 , pp. 1001-1012
    • Zhu, G.1    Wang, Y.2    Huang, B.3    Liang, J.4    Ding, Y.5    Xu, A.6
  • 15
    • 0034733041 scopus 로고    scopus 로고
    • Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1
    • Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH. Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem 2000;275:19693-9.
    • (2000) J Biol Chem , vol.275 , pp. 19693-19699
    • Frost, J.A.1    Swantek, J.L.2    Stippec, S.3    Yin, M.J.4    Gaynor, R.5    Cobb, M.H.6
  • 16
    • 80053294770 scopus 로고    scopus 로고
    • Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation
    • Selyunin AS, Alto NM. Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation. Small GTPases 2011;2:217-21.
    • (2011) Small GTPases , vol.2 , pp. 217-221
    • Selyunin, A.S.1    Alto, N.M.2
  • 18
    • 84927759580 scopus 로고    scopus 로고
    • Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer
    • Khare V, Dammann K, Asboth M, Krnjic A, Jambrich M, Gasche C. Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer. Inflamm Bowel Dis 2015;21:287-96.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 287-296
    • Khare, V.1    Dammann, K.2    Asboth, M.3    Krnjic, A.4    Jambrich, M.5    Gasche, C.6
  • 20
    • 84856336786 scopus 로고    scopus 로고
    • P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth
    • He H, Huynh N, Liu KH, Malcontenti-Wilson C, Zhu J, Christophi C, et al. P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth. Cancer Lett 2012;317:65-71.
    • (2012) Cancer Lett , vol.317 , pp. 65-71
    • He, H.1    Huynh, N.2    Liu, K.H.3    Malcontenti-Wilson, C.4    Zhu, J.5    Christophi, C.6
  • 22
    • 58149401317 scopus 로고    scopus 로고
    • Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/-mast cells
    • McDaniel AS, Allen JD, Park SJ, Jaffer ZM, Michels EG, Burgin SJ, et al. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/-mast cells. Blood 2008;112:4646-54.
    • (2008) Blood , vol.112 , pp. 4646-4654
    • McDaniel, A.S.1    Allen, J.D.2    Park, S.J.3    Jaffer, Z.M.4    Michels, E.G.5    Burgin, S.J.6
  • 23
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993;69:238-49.
    • (1993) Lab Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3    Sedergran, D.J.4
  • 24
    • 29744461120 scopus 로고    scopus 로고
    • Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice
    • Suzuki R, Kohno H, Sugie S, Nakagama H, Tanaka T. Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis 2006;27:162-9.
    • (2006) Carcinogenesis , vol.27 , pp. 162-169
    • Suzuki, R.1    Kohno, H.2    Sugie, S.3    Nakagama, H.4    Tanaka, T.5
  • 26
    • 55549119209 scopus 로고    scopus 로고
    • Scaffolding function of PAK in the PDK1-Akt pathway
    • Higuchi M, Onishi K, Kikuchi C, Gotoh Y. Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 2008;10:1356-64.
    • (2008) Nat Cell Biol , vol.10 , pp. 1356-1364
    • Higuchi, M.1    Onishi, K.2    Kikuchi, C.3    Gotoh, Y.4
  • 28
    • 84868677242 scopus 로고    scopus 로고
    • 5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer
    • Baan B, Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, et al. 5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. Gut 2012;61:1708-15.
    • (2012) Gut , vol.61 , pp. 1708-1715
    • Baan, B.1    Dihal, A.A.2    Hoff, E.3    Bos, C.L.4    Voorneveld, P.W.5    Koelink, P.J.6
  • 29
    • 39649094305 scopus 로고    scopus 로고
    • Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: A clinical review and update
    • Rubin DT, Cruz-Correa MR, Gasche C, Jass JR, Lichtenstein GR, Montgomery EA, et al. Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update. Inflamm Bowel Dis 2008;14:265-74.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 265-274
    • Rubin, D.T.1    Cruz-Correa, M.R.2    Gasche, C.3    Jass, J.R.4    Lichtenstein, G.R.5    Montgomery, E.A.6
  • 31
    • 84255173556 scopus 로고    scopus 로고
    • Wnt signaling and colon carcinogenesis: Beyond APC
    • Najdi R, Holcombe RF, Waterman ML. Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog 2011;10:5.
    • (2011) J Carcinog , vol.10 , pp. 5
    • Najdi, R.1    Holcombe, R.F.2    Waterman, M.L.3
  • 32
    • 84863756127 scopus 로고    scopus 로고
    • Wnt signaling, stem cells, and cancer of the gastrointestinal tract
    • Schepers A, Clevers H. Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harbor Perspect Biol 2012;4:a007989.
    • (2012) Cold Spring Harbor Perspect Biol , vol.4 , pp. a007989
    • Schepers, A.1    Clevers, H.2
  • 33
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992;256:668-70.
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.3    Preisinger, A.C.4    Moser, A.R.5    Luongo, C.6
  • 35
    • 0037472647 scopus 로고    scopus 로고
    • Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells
    • Mazumdar A, Kumar R. Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. FEBS Lett 2003;535:6-10.
    • (2003) FEBS Lett , vol.535 , pp. 6-10
    • Mazumdar, A.1    Kumar, R.2
  • 36
    • 84867625987 scopus 로고    scopus 로고
    • Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells
    • Gu S, Kounenidakis M, Schmidt EM, Deshpande D, Alkahtani S, Alarifi S, et al. Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells. Cell Signal 2013;25:66-73.
    • (2013) Cell Signal , vol.25 , pp. 66-73
    • Gu, S.1    Kounenidakis, M.2    Schmidt, E.M.3    Deshpande, D.4    Alkahtani, S.5    Alarifi, S.6
  • 37
    • 20944445862 scopus 로고    scopus 로고
    • Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma
    • Rousseaux C, Lefebvre B, Dubuquoy L, Lefebvre P, Romano O, Auwerx J, et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med 2005;201:1205-15.
    • (2005) J Exp Med , vol.201 , pp. 1205-1215
    • Rousseaux, C.1    Lefebvre, B.2    Dubuquoy, L.3    Lefebvre, P.4    Romano, O.5    Auwerx, J.6
  • 38
    • 84862816551 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of PAK4 modulates beta-catenin intracellular translocation and signaling
    • Li Y, Shao Y, Tong Y, Shen T, Zhang J, Li Y, et al. Nucleo-cytoplasmic shuttling of PAK4 modulates beta-catenin intracellular translocation and signaling. Biochim Biophys Acta 2012;1823:465-75.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 465-475
    • Li, Y.1    Shao, Y.2    Tong, Y.3    Shen, T.4    Zhang, J.5    Li, Y.6
  • 39
    • 45349108467 scopus 로고    scopus 로고
    • COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells
    • Pham H, Vincenti R, Slice LW. COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells. Biochim Biophys Acta 2008;1779:408-13.
    • (2008) Biochim Biophys Acta , vol.1779 , pp. 408-413
    • Pham, H.1    Vincenti, R.2    Slice, L.W.3
  • 40
    • 77956640958 scopus 로고    scopus 로고
    • Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression
    • Wu R, Abramson AL, Symons MH, Steinberg BM. Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression. Int J Cancer 2010;127:2230-7.
    • (2010) Int J Cancer , vol.127 , pp. 2230-2237
    • Wu, R.1    Abramson, A.L.2    Symons, M.H.3    Steinberg, B.M.4
  • 41
    • 14944380553 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling
    • Paccani SR, Patrussi L, Ulivieri C, Masferrer JL, D'Elios MM, Baldari CT. Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling. Blood 2005;105:2042-8.
    • (2005) Blood , vol.105 , pp. 2042-2048
    • Paccani, S.R.1    Patrussi, L.2    Ulivieri, C.3    Masferrer, J.L.4    D'Elios, M.M.5    Baldari, C.T.6
  • 42
    • 63849230362 scopus 로고    scopus 로고
    • p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
    • Allen JD, Jaffer ZM, Park SJ, Burgin S, Hofmann C, Sells MA, et al. p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood 2009;113:2695-705.
    • (2009) Blood , vol.113 , pp. 2695-2705
    • Allen, J.D.1    Jaffer, Z.M.2    Park, S.J.3    Burgin, S.4    Hofmann, C.5    Sells, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.