-
2
-
-
21344446543
-
Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: A systematic review and metaanalysis of observational studies
-
Velayos FS, Terdiman JP, Walsh JM. Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am J Gastroenterol 2005;100:1345-53.
-
(2005)
Am J Gastroenterol
, vol.100
, pp. 1345-1353
-
-
Velayos, F.S.1
Terdiman, J.P.2
Walsh, J.M.3
-
3
-
-
84887000015
-
The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARgamma
-
Rousseaux C, El-Jamal N, Fumery M, Dubuquoy C, Romano O, Chatelain D, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARgamma. Carcinogenesis 2013;34:2580-6.
-
(2013)
Carcinogenesis
, vol.34
, pp. 2580-2586
-
-
Rousseaux, C.1
El-Jamal, N.2
Fumery, M.3
Dubuquoy, C.4
Romano, O.5
Chatelain, D.6
-
4
-
-
72949095645
-
Systematic review: Molecular chemoprevention of colorectal malignancy by mesalazine
-
Lyakhovich A, Gasche C. Systematic review: molecular chemoprevention of colorectal malignancy by mesalazine. Aliment Pharmacol Ther 2010;31:202-9.
-
(2010)
Aliment Pharmacol Ther
, vol.31
, pp. 202-209
-
-
Lyakhovich, A.1
Gasche, C.2
-
5
-
-
84884538411
-
Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells
-
Managlia E, Katzman RB, Brown JB, Barrett TA. Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells. Inflamm Bowel Dis 2013;19:2051-60.
-
(2013)
Inflamm Bowel Dis
, vol.19
, pp. 2051-2060
-
-
Managlia, E.1
Katzman, R.B.2
Brown, J.B.3
Barrett, T.A.4
-
6
-
-
33846231453
-
5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint
-
Luciani MG, Campregher C, Fortune JM, Kunkel TA, Gasche C. 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. Gastroenterology 2007;132:221-35.
-
(2007)
Gastroenterology
, vol.132
, pp. 221-235
-
-
Luciani, M.G.1
Campregher, C.2
Fortune, J.M.3
Kunkel, T.A.4
Gasche, C.5
-
7
-
-
75149198407
-
Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis
-
e1-3
-
Brown JB, Lee G, Managlia E, Grimm GR, Dirisina R, Goretsky T, et al. Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology 2010;138:595-605, e1-3.
-
(2010)
Gastroenterology
, vol.138
, pp. 595-605
-
-
Brown, J.B.1
Lee, G.2
Managlia, E.3
Grimm, G.R.4
Dirisina, R.5
Goretsky, T.6
-
8
-
-
33645101399
-
A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon
-
Kim H, Jeon H, Kong H, Yang Y, Choi B, Kim YM, et al. A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon. Mol Pharmacol 2006;69:1405-12.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1405-1412
-
-
Kim, H.1
Jeon, H.2
Kong, H.3
Yang, Y.4
Choi, B.5
Kim, Y.M.6
-
9
-
-
84892366425
-
Modulation of N-glycosylation by mesalamine facilitates membranous Ecadherin expression in colon epithelial cells
-
Khare V, Lang M, Dammann K, Campregher C, Lyakhovich A, Gasche C. Modulation of N-glycosylation by mesalamine facilitates membranous Ecadherin expression in colon epithelial cells. Biochem Pharmacol 2014;87:312-20.
-
(2014)
Biochem Pharmacol
, vol.87
, pp. 312-320
-
-
Khare, V.1
Lang, M.2
Dammann, K.3
Campregher, C.4
Lyakhovich, A.5
Gasche, C.6
-
10
-
-
84872026149
-
Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1
-
Khare V, Lyakhovich A, Dammann K, Lang M, Borgmann M, Tichy B, et al. Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochem Pharmacol 2013;85:234-44.
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 234-244
-
-
Khare, V.1
Lyakhovich, A.2
Dammann, K.3
Lang, M.4
Borgmann, M.5
Tichy, B.6
-
11
-
-
84863968373
-
Molecular pathways: Targeting p21-activated kinase 1 signaling in cancer-opportunities, challenges, and limitations
-
Eswaran J, Li DQ, Shah A, Kumar R. Molecular pathways: targeting p21-activated kinase 1 signaling in cancer-opportunities, challenges, and limitations. Clin Cancer Res 2012;18:3743-9.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3743-3749
-
-
Eswaran, J.1
Li, D.Q.2
Shah, A.3
Kumar, R.4
-
12
-
-
84902292389
-
Tracing PAKs from GI inflammation to cancer
-
Dammann K, Khare V, Gasche C. Tracing PAKs from GI inflammation to cancer. Gut 2014;63:1173-84.
-
(2014)
Gut
, vol.63
, pp. 1173-1184
-
-
Dammann, K.1
Khare, V.2
Gasche, C.3
-
13
-
-
84857364721
-
A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells
-
Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, et al. A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells. Oncogene 2012;31:1001-12.
-
(2012)
Oncogene
, vol.31
, pp. 1001-1012
-
-
Zhu, G.1
Wang, Y.2
Huang, B.3
Liang, J.4
Ding, Y.5
Xu, A.6
-
14
-
-
84862781182
-
Phosphorylation of beta-catenin at serine 663 regulates its transcriptional activity
-
Park MH, Kim DJ, You ST, Lee CS, Kim HK, Park SM, et al. Phosphorylation of beta-catenin at serine 663 regulates its transcriptional activity. Biochem Biophys Res Commun 2012;419:543-9.
-
(2012)
Biochem Biophys Res Commun
, vol.419
, pp. 543-549
-
-
Park, M.H.1
Kim, D.J.2
You, S.T.3
Lee, C.S.4
Kim, H.K.5
Park, S.M.6
-
15
-
-
0034733041
-
Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1
-
Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH. Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem 2000;275:19693-9.
-
(2000)
J Biol Chem
, vol.275
, pp. 19693-19699
-
-
Frost, J.A.1
Swantek, J.L.2
Stippec, S.3
Yin, M.J.4
Gaynor, R.5
Cobb, M.H.6
-
16
-
-
80053294770
-
Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation
-
Selyunin AS, Alto NM. Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation. Small GTPases 2011;2:217-21.
-
(2011)
Small GTPases
, vol.2
, pp. 217-221
-
-
Selyunin, A.S.1
Alto, N.M.2
-
17
-
-
84938118568
-
PAK1 modulates a PPARgamma/NF-kappaB cascade in intestinal inflammation
-
Dammann K, Khare V, Lang M, Claudel T, Harpain F, Granofszky N, et al. PAK1 modulates a PPARgamma/NF-kappaB cascade in intestinal inflammation. Biochim Biophys Acta 2015;1853:2349-60.
-
(2015)
Biochim Biophys Acta
, vol.1853
, pp. 2349-2360
-
-
Dammann, K.1
Khare, V.2
Lang, M.3
Claudel, T.4
Harpain, F.5
Granofszky, N.6
-
18
-
-
84927759580
-
Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer
-
Khare V, Dammann K, Asboth M, Krnjic A, Jambrich M, Gasche C. Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer. Inflamm Bowel Dis 2015;21:287-96.
-
(2015)
Inflamm Bowel Dis
, vol.21
, pp. 287-296
-
-
Khare, V.1
Dammann, K.2
Asboth, M.3
Krnjic, A.4
Jambrich, M.5
Gasche, C.6
-
19
-
-
2542452838
-
Pak-1 expression increases with progression of colorectal carcinomas to metastasis
-
Carter JH, Douglass LE, Deddens JA, Colligan BM, Bhatt TR, Pemberton JO, et al. Pak-1 expression increases with progression of colorectal carcinomas to metastasis. Clin Cancer Res 2004;10:3448-56.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3448-3456
-
-
Carter, J.H.1
Douglass, L.E.2
Deddens, J.A.3
Colligan, B.M.4
Bhatt, T.R.5
Pemberton, J.O.6
-
20
-
-
84856336786
-
P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth
-
He H, Huynh N, Liu KH, Malcontenti-Wilson C, Zhu J, Christophi C, et al. P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth. Cancer Lett 2012;317:65-71.
-
(2012)
Cancer Lett
, vol.317
, pp. 65-71
-
-
He, H.1
Huynh, N.2
Liu, K.H.3
Malcontenti-Wilson, C.4
Zhu, J.5
Christophi, C.6
-
21
-
-
84877617487
-
Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
-
Lang M, Borgmann M, Oberhuber G, Evstatiev R, Jimenez K, Dammann KW, et al. Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling. Mol Cancer 2013;12:41.
-
(2013)
Mol Cancer
, vol.12
, pp. 41
-
-
Lang, M.1
Borgmann, M.2
Oberhuber, G.3
Evstatiev, R.4
Jimenez, K.5
Dammann, K.W.6
-
22
-
-
58149401317
-
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/-mast cells
-
McDaniel AS, Allen JD, Park SJ, Jaffer ZM, Michels EG, Burgin SJ, et al. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/-mast cells. Blood 2008;112:4646-54.
-
(2008)
Blood
, vol.112
, pp. 4646-4654
-
-
McDaniel, A.S.1
Allen, J.D.2
Park, S.J.3
Jaffer, Z.M.4
Michels, E.G.5
Burgin, S.J.6
-
23
-
-
0027224059
-
Clinicopathologic study of dextran sulfate sodium experimental murine colitis
-
Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993;69:238-49.
-
(1993)
Lab Invest
, vol.69
, pp. 238-249
-
-
Cooper, H.S.1
Murthy, S.N.2
Shah, R.S.3
Sedergran, D.J.4
-
24
-
-
29744461120
-
Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice
-
Suzuki R, Kohno H, Sugie S, Nakagama H, Tanaka T. Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis 2006;27:162-9.
-
(2006)
Carcinogenesis
, vol.27
, pp. 162-169
-
-
Suzuki, R.1
Kohno, H.2
Sugie, S.3
Nakagama, H.4
Tanaka, T.5
-
25
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker N, Ridgway RA, Van Es JH, Van De Wetering M, Begthel H, Van Den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457:608-11.
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
Van Es, J.H.3
Van De Wetering, M.4
Begthel, H.5
Van Den Born, M.6
-
28
-
-
84868677242
-
5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer
-
Baan B, Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, et al. 5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. Gut 2012;61:1708-15.
-
(2012)
Gut
, vol.61
, pp. 1708-1715
-
-
Baan, B.1
Dihal, A.A.2
Hoff, E.3
Bos, C.L.4
Voorneveld, P.W.5
Koelink, P.J.6
-
29
-
-
39649094305
-
Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: A clinical review and update
-
Rubin DT, Cruz-Correa MR, Gasche C, Jass JR, Lichtenstein GR, Montgomery EA, et al. Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update. Inflamm Bowel Dis 2008;14:265-74.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 265-274
-
-
Rubin, D.T.1
Cruz-Correa, M.R.2
Gasche, C.3
Jass, J.R.4
Lichtenstein, G.R.5
Montgomery, E.A.6
-
32
-
-
84863756127
-
Wnt signaling, stem cells, and cancer of the gastrointestinal tract
-
Schepers A, Clevers H. Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harbor Perspect Biol 2012;4:a007989.
-
(2012)
Cold Spring Harbor Perspect Biol
, vol.4
, pp. a007989
-
-
Schepers, A.1
Clevers, H.2
-
33
-
-
0026562404
-
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
-
Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992;256:668-70.
-
(1992)
Science
, vol.256
, pp. 668-670
-
-
Su, L.K.1
Kinzler, K.W.2
Vogelstein, B.3
Preisinger, A.C.4
Moser, A.R.5
Luongo, C.6
-
34
-
-
33846988274
-
Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse
-
Ignatenko NA, Holubec H, Besselsen DG, Blohm-Mangone KA, Padilla-Torres JL, Nagle RB, et al. Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse. Cancer Biol Ther 2006;5:1658-64.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 1658-1664
-
-
Ignatenko, N.A.1
Holubec, H.2
Besselsen, D.G.3
Blohm-Mangone, K.A.4
Padilla-Torres, J.L.5
Nagle, R.B.6
-
35
-
-
0037472647
-
Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells
-
Mazumdar A, Kumar R. Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. FEBS Lett 2003;535:6-10.
-
(2003)
FEBS Lett
, vol.535
, pp. 6-10
-
-
Mazumdar, A.1
Kumar, R.2
-
36
-
-
84867625987
-
Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells
-
Gu S, Kounenidakis M, Schmidt EM, Deshpande D, Alkahtani S, Alarifi S, et al. Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells. Cell Signal 2013;25:66-73.
-
(2013)
Cell Signal
, vol.25
, pp. 66-73
-
-
Gu, S.1
Kounenidakis, M.2
Schmidt, E.M.3
Deshpande, D.4
Alkahtani, S.5
Alarifi, S.6
-
37
-
-
20944445862
-
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma
-
Rousseaux C, Lefebvre B, Dubuquoy L, Lefebvre P, Romano O, Auwerx J, et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med 2005;201:1205-15.
-
(2005)
J Exp Med
, vol.201
, pp. 1205-1215
-
-
Rousseaux, C.1
Lefebvre, B.2
Dubuquoy, L.3
Lefebvre, P.4
Romano, O.5
Auwerx, J.6
-
38
-
-
84862816551
-
Nucleo-cytoplasmic shuttling of PAK4 modulates beta-catenin intracellular translocation and signaling
-
Li Y, Shao Y, Tong Y, Shen T, Zhang J, Li Y, et al. Nucleo-cytoplasmic shuttling of PAK4 modulates beta-catenin intracellular translocation and signaling. Biochim Biophys Acta 2012;1823:465-75.
-
(2012)
Biochim Biophys Acta
, vol.1823
, pp. 465-475
-
-
Li, Y.1
Shao, Y.2
Tong, Y.3
Shen, T.4
Zhang, J.5
Li, Y.6
-
39
-
-
45349108467
-
COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells
-
Pham H, Vincenti R, Slice LW. COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells. Biochim Biophys Acta 2008;1779:408-13.
-
(2008)
Biochim Biophys Acta
, vol.1779
, pp. 408-413
-
-
Pham, H.1
Vincenti, R.2
Slice, L.W.3
-
40
-
-
77956640958
-
Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression
-
Wu R, Abramson AL, Symons MH, Steinberg BM. Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression. Int J Cancer 2010;127:2230-7.
-
(2010)
Int J Cancer
, vol.127
, pp. 2230-2237
-
-
Wu, R.1
Abramson, A.L.2
Symons, M.H.3
Steinberg, B.M.4
-
41
-
-
14944380553
-
Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling
-
Paccani SR, Patrussi L, Ulivieri C, Masferrer JL, D'Elios MM, Baldari CT. Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling. Blood 2005;105:2042-8.
-
(2005)
Blood
, vol.105
, pp. 2042-2048
-
-
Paccani, S.R.1
Patrussi, L.2
Ulivieri, C.3
Masferrer, J.L.4
D'Elios, M.M.5
Baldari, C.T.6
-
42
-
-
63849230362
-
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
-
Allen JD, Jaffer ZM, Park SJ, Burgin S, Hofmann C, Sells MA, et al. p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood 2009;113:2695-705.
-
(2009)
Blood
, vol.113
, pp. 2695-2705
-
-
Allen, J.D.1
Jaffer, Z.M.2
Park, S.J.3
Burgin, S.4
Hofmann, C.5
Sells, M.A.6
|