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Volumn 34, Issue 11, 2013, Pages 2580-2586

The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 5 ACETAMIDOSALICYLIC ACID; AZOXYMETHANE; ETOPOSIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

EID: 84887000015     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt245     Document Type: Article
Times cited : (33)

References (44)
  • 1
    • 73249137810 scopus 로고    scopus 로고
    • Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study
    • Leung,K. et al. (2010) Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study. Gastrointest. Endosc., 71, 111-117.
    • (2010) Gastrointest. Endosc , vol.71 , pp. 111-117
    • Leung, K.1
  • 2
    • 21344446543 scopus 로고    scopus 로고
    • Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies
    • Velayos,F.S. et al. (2005) Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am. J. Gastroenterol., 100, 1345-1353.
    • (2005) Am. J. Gastroenterol , vol.100 , pp. 1345-1353
    • Velayos, F.S.1
  • 3
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: a meta-analysis
    • Eaden,J.A. et al. (2001) The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut, 48, 526-535.
    • (2001) Gut , vol.48 , pp. 526-535
    • Eaden, J.A.1
  • 4
    • 0033623301 scopus 로고    scopus 로고
    • 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer
    • Brown,W.A. et al. (2000) 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig. Dis. Sci., 45, 1578-1584.
    • (2000) Dig. Dis. Sci , vol.45 , pp. 1578-1584
    • Brown, W.A.1
  • 5
    • 35948935272 scopus 로고    scopus 로고
    • 5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model
    • Ikeda,I. et al. (2007) 5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model. Clin. Cancer Res., 13, 6527-6531.
    • (2007) Clin. Cancer Res , vol.13 , pp. 6527-6531
    • Ikeda, I.1
  • 6
    • 57149109314 scopus 로고    scopus 로고
    • 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    • Clapper,M.L. et al. (2008) 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis. Inflamm. Bowel Dis., 14, 1341-1347.
    • (2008) Inflamm. Bowel Dis , vol.14 , pp. 1341-1347
    • Clapper, M.L.1
  • 7
    • 0033637218 scopus 로고    scopus 로고
    • Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis
    • Bantel,H. et al. (2000) Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am. J. Gastroenterol., 95, 3452-3457.
    • (2000) Am. J. Gastroenterol , vol.95 , pp. 3452-3457
    • Bantel, H.1
  • 8
    • 0032032469 scopus 로고    scopus 로고
    • Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
    • Wahl,C. et al. (1998) Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest., 101, 1163-1174.
    • (1998) J. Clin. Invest , vol.101 , pp. 1163-1174
    • Wahl, C.1
  • 9
    • 33845352518 scopus 로고    scopus 로고
    • Protein phosphatase 2A is required for mesalazinedependent inhibition of Wnt/beta-catenin pathway activity
    • Bos,C.L. et al. (2006) Protein phosphatase 2A is required for mesalazinedependent inhibition of Wnt/beta-catenin pathway activity. Carcinogenesis, 27, 2371-2382.
    • (2006) Carcinogenesis , vol.27 , pp. 2371-2382
    • Bos, C.L.1
  • 10
    • 77949770716 scopus 로고    scopus 로고
    • Mesalazine reduces mutations in transforming growth factor beta receptor II and activin type II receptor by improvement of replication fidelity in mononucleotide repeats
    • Campregher,C. et al. (2010) Mesalazine reduces mutations in transforming growth factor beta receptor II and activin type II receptor by improvement of replication fidelity in mononucleotide repeats. Clin. Cancer Res., 16, 1950-1956.
    • (2010) Clin. Cancer Res , vol.16 , pp. 1950-1956
    • Campregher, C.1
  • 11
    • 46949090796 scopus 로고    scopus 로고
    • Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase
    • Stolfi,C. et al. (2008) Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase. Carcinogenesis, 29, 1258-1266.
    • (2008) Carcinogenesis , vol.29 , pp. 1258-1266
    • Stolfi, C.1
  • 12
    • 72049122914 scopus 로고    scopus 로고
    • 5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells
    • Koelink,P.J. et al. (2010) 5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells. Cancer Lett., 287, 82-90.
    • (2010) Cancer Lett , vol.287 , pp. 82-90
    • Koelink, P.J.1
  • 13
    • 30844460628 scopus 로고    scopus 로고
    • Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells
    • Monteleone,G. et al. (2006) Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells. Cell Death Differ., 13, 202-211.
    • (2006) Cell Death Differ , vol.13 , pp. 202-211
    • Monteleone, G.1
  • 14
    • 0031671246 scopus 로고    scopus 로고
    • Differentiation and reversal of malignant changes in colon cancer through PPARgamma
    • Sarraf,P. et al. (1998) Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat. Med., 4, 1046-1052.
    • (1998) Nat. Med , vol.4 , pp. 1046-1052
    • Sarraf, P.1
  • 15
    • 20944445862 scopus 로고    scopus 로고
    • Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptorgamma
    • Rousseaux,C. et al. (2005) Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptorgamma. J. Exp. Med., 201, 1205-1215.
    • (2005) J. Exp. Med , vol.201 , pp. 1205-1215
    • Rousseaux, C.1
  • 16
    • 3042815666 scopus 로고    scopus 로고
    • Antineoplastic effects of peroxisome proliferator- activated receptor gamma agonists
    • Grommes,C. et al. (2004) Antineoplastic effects of peroxisome proliferator- activated receptor gamma agonists. Lancet Oncol., 5, 419-429.
    • (2004) Lancet Oncol , vol.5 , pp. 419-429
    • Grommes, C.1
  • 17
    • 0037309496 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice
    • Osawa,E. et al. (2003) Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology, 124, 361-367.
    • (2003) Gastroenterology , vol.124 , pp. 361-367
    • Osawa, E.1
  • 18
    • 0034242215 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) gamma: a new target for the treatment of inflammatory bowel disease
    • Dubuquoy,L. et al. (2000) Peroxisome proliferator-activated receptor (PPAR) gamma: a new target for the treatment of inflammatory bowel disease. Gastroenterol. Clin. Biol., 24, 719-724.
    • (2000) Gastroenterol. Clin. Biol , vol.24 , pp. 719-724
    • Dubuquoy, L.1
  • 19
    • 0037010478 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases
    • Dubuquoy,L. et al. (2002) Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet, 360, 1410-1418.
    • (2002) Lancet , vol.360 , pp. 1410-1418
    • Dubuquoy, L.1
  • 20
    • 0025243656 scopus 로고
    • Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion
    • Staerk Laursen,L. et al. (1990) Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion. Gut, 31, 1271-1276.
    • (1990) Gut , vol.31 , pp. 1271-1276
    • Staerk Laursen, L.1
  • 21
    • 0032701176 scopus 로고    scopus 로고
    • Rectal and colonic mesalazine concentration in ulcerative colitis: oral vs. oral plus topical treatment
    • Frieri,G. et al. (1999) Rectal and colonic mesalazine concentration in ulcerative colitis: oral vs. oral plus topical treatment. Aliment. Pharmacol. Ther., 13, 1413-1417.
    • (1999) Aliment. Pharmacol. Ther , vol.13 , pp. 1413-1417
    • Frieri, G.1
  • 22
    • 0022649091 scopus 로고
    • Tumor measurement in the nude mouse
    • Euhus,D.M. et al. (1986) Tumor measurement in the nude mouse. J. Surg. Oncol., 31, 229-234.
    • (1986) J. Surg. Oncol , vol.31 , pp. 229-234
    • Euhus, D.M.1
  • 23
    • 0032516640 scopus 로고    scopus 로고
    • Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility
    • Papanikolaou,A. et al. (1998) Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility. Cancer Lett., 130, 29-34.
    • (1998) Cancer Lett , vol.130 , pp. 29-34
    • Papanikolaou, A.1
  • 24
    • 59249098280 scopus 로고    scopus 로고
    • Colorectal cancer surveillance in inflammatory bowel disease: the search continues
    • Ahmadi,A. et al. (2009) Colorectal cancer surveillance in inflammatory bowel disease: the search continues. World J. Gastroenterol., 15, 61-66.
    • (2009) World J. Gastroenterol , vol.15 , pp. 61-66
    • Ahmadi, A.1
  • 25
    • 39649094305 scopus 로고    scopus 로고
    • Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update
    • Rubin,D.T. et al. (2008) Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update. Inflamm. Bowel Dis., 14, 265-274.
    • (2008) Inflamm. Bowel Dis , vol.14 , pp. 265-274
    • Rubin, D.T.1
  • 26
    • 33750797496 scopus 로고    scopus 로고
    • Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis
    • Rubin,D.T. et al. (2006) Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis. Clin. Gastroenterol. Hepatol., 4, 1346-1350.
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 1346-1350
    • Rubin, D.T.1
  • 27
    • 84863665380 scopus 로고    scopus 로고
    • Colorectal cancer chemoprevention by mesalazine and its derivatives
    • Stolfi,C. et al. (2012) Colorectal cancer chemoprevention by mesalazine and its derivatives. J. Biomed. Biotechnol., 2012, 980458.
    • (2012) J. Biomed. Biotechnol , vol.2012 , pp. 980458
    • Stolfi, C.1
  • 28
    • 37849007849 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid
    • Stolfi,C. et al. (2008) Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid. Biochem. Pharmacol., 75, 668-676.
    • (2008) Biochem. Pharmacol , vol.75 , pp. 668-676
    • Stolfi, C.1
  • 29
    • 0037355174 scopus 로고    scopus 로고
    • Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells
    • Reinacher-Schick,A. et al. (2003) Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells. Carcinogenesis, 24, 443-451.
    • (2003) Carcinogenesis , vol.24 , pp. 443-451
    • Reinacher-Schick, A.1
  • 30
    • 0031882916 scopus 로고    scopus 로고
    • Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
    • Chan,T.A. et al. (1998) Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc. Natl Acad. Sci. USA, 95, 681-686.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 681-686
    • Chan, T.A.1
  • 31
    • 49349100984 scopus 로고    scopus 로고
    • PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells
    • Schwab,M. et al. (2008) PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. Carcinogenesis, 29, 1407-1414.
    • (2008) Carcinogenesis , vol.29 , pp. 1407-1414
    • Schwab, M.1
  • 32
    • 34249781974 scopus 로고    scopus 로고
    • Mesalazine downregulates c-Myc in human colon cancer cells. A key to its chemopreventive action?
    • Chu,E.C. et al. (2007) Mesalazine downregulates c-Myc in human colon cancer cells. A key to its chemopreventive action? Aliment. Pharmacol. Ther., 25, 1443-1449.
    • (2007) Aliment. Pharmacol. Ther , vol.25 , pp. 1443-1449
    • Chu, E.C.1
  • 33
    • 0035866756 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats
    • Tanaka,T. et al. (2001) Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res., 61, 2424-2428.
    • (2001) Cancer Res , vol.61 , pp. 2424-2428
    • Tanaka, T.1
  • 34
    • 67650109585 scopus 로고    scopus 로고
    • 5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model
    • Koelink,P.J. et al. (2009) 5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model. Carcinogenesis, 30, 1217-1224.
    • (2009) Carcinogenesis , vol.30 , pp. 1217-1224
    • Koelink, P.J.1
  • 35
    • 0031694577 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferatoractivated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
    • Lefebvre,A.M. et al. (1998) Activation of the peroxisome proliferatoractivated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat. Med., 4, 1053-1057.
    • (1998) Nat. Med , vol.4 , pp. 1053-1057
    • Lefebvre, A.M.1
  • 36
    • 0031667938 scopus 로고    scopus 로고
    • Activators of the nuclear receptor PPARgamma enhance colon polyp formation
    • Saez,E. et al. (1998) Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat. Med., 4, 1058-1061.
    • (1998) Nat. Med , vol.4 , pp. 1058-1061
    • Saez, E.1
  • 37
    • 0037109043 scopus 로고    scopus 로고
    • APC-dependent suppression of colon carcinogenesis by PPARgamma
    • Girnun,G.D. et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc. Natl Acad. Sci. USA, 99, 13771-13776.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13771-13776
    • Girnun, G.D.1
  • 38
    • 0036730017 scopus 로고    scopus 로고
    • A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer
    • Kulke,M.H. et al. (2002) A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J., 8, 395-399.
    • (2002) Cancer J , vol.8 , pp. 395-399
    • Kulke, M.H.1
  • 39
    • 0037847511 scopus 로고    scopus 로고
    • Impaired expression of peroxisome proliferatoractivated receptor gamma in ulcerative colitis
    • Dubuquoy,L. et al. (2003) Impaired expression of peroxisome proliferatoractivated receptor gamma in ulcerative colitis. Gastroenterology, 124, 1265-1276.
    • (2003) Gastroenterology , vol.124 , pp. 1265-1276
    • Dubuquoy, L.1
  • 40
    • 0033980980 scopus 로고    scopus 로고
    • Colorectal cancer prevention in ulcerative colitis: a case-control study
    • Eaden,J. et al. (2000) Colorectal cancer prevention in ulcerative colitis: a case-control study. Aliment. Pharmacol. Ther., 14, 145-153.
    • (2000) Aliment. Pharmacol. Ther , vol.14 , pp. 145-153
    • Eaden, J.1
  • 41
    • 25144459131 scopus 로고    scopus 로고
    • 5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study
    • van Staa,T.P. et al. (2005) 5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study. Gut, 54, 1573-1578.
    • (2005) Gut , vol.54 , pp. 1573-1578
    • Van Staa, T.P.1
  • 42
    • 84866076674 scopus 로고    scopus 로고
    • 5-Aminosalicylic acid is not protective against colorectal cancer in inflammatory bowel disease: a meta-analysis of nonreferral populations
    • Nguyen,G.C. et al. (2012) 5-Aminosalicylic acid is not protective against colorectal cancer in inflammatory bowel disease: a meta-analysis of nonreferral populations. Am. J. Gastroenterol., 107, 1298-1304.
    • (2012) Am. J. Gastroenterol , vol.107 , pp. 1298-1304
    • Nguyen, G.C.1
  • 43
    • 0347994976 scopus 로고    scopus 로고
    • Does the use of 5-aminosalicylates in inflammatory bowel disease prevent the development of colorectal cancer?
    • Bernstein,C.N. et al. (2003) Does the use of 5-aminosalicylates in inflammatory bowel disease prevent the development of colorectal cancer? Am. J. Gastroenterol., 98, 2784-2788.
    • (2003) Am. J. Gastroenterol , vol.98 , pp. 2784-2788
    • Bernstein, C.N.1
  • 44
    • 34247564971 scopus 로고    scopus 로고
    • 5-Aminosalicylic acid therapy and the risk of colorectal cancer among patients with inflammatory bowel disease
    • Terdiman,J.P. et al. (2007) 5-Aminosalicylic acid therapy and the risk of colorectal cancer among patients with inflammatory bowel disease. Inflamm. Bowel Dis., 13, 367-371.
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 367-371
    • Terdiman, J.P.1


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