Directed evolution of the Escherichia coli cAMP receptor protein at the cAMP pocket

Journal of Biological Chemistry

Volumn 290, Issue 44, 2015, Pages 26587-26596

  Gunasekara, Sanjiva M ^a   Hicks, Matt N ^a   Park, Jin ^a   Brooks, Cory L ^a   Serate, Jose ^b   Saunders, Cameron V ^a   Grover, Simranjeet K ^a   Goto, Joy J ^a   Lee, Jin Won ^c   Youn, Hwan ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; EVOLUTIONARY ALGORITHMS;

CAMP RECEPTOR PROTEINS; CONSERVED RESIDUES; DIRECTED EVOLUTION; MULTIPLE EVOLUTIONARY STRATEGIES;

PROTEINS;

ASPARAGINE; CYCLIC AMP BINDING PROTEIN; SERINE; THREONINE; BACTERIAL DNA; CODON; CRP PROTEIN, E COLI; CYCLIC AMP; ESCHERICHIA COLI PROTEIN; PROTEIN BINDING;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CODON; CONTROLLED STUDY; DIRECTED MOLECULAR EVOLUTION; DNA BINDING; DNA SEQUENCE; ESCHERICHIA COLI; GENETIC CONSERVATION; HYDROGEN BOND; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; ALLOSTERISM; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR MODEL; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; CODON; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC AMP RECEPTOR PROTEIN; DIRECTED MOLECULAR EVOLUTION; DNA, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, BACTERIAL; HYDROGEN BONDING; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE; THREONINE; TRANSCRIPTION, GENETIC;

EID: 84946052668     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.678474     Document Type: Article

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