Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 39, 2009, Pages 16604-16609

  Sharma, Hitesh ^a   Yu, Shaoning ^b   Kong, Jilie ^b   Wang, Jimin ^a   Steitz, Thomas A ^a,c  

^a YALE UNIVERSITY   (United States)

^b FUDAN UNIVERSITY   (China)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Allostery; cAMP; Helix turn helix; Transcription activator

Indexed keywords

APO CYCLIC AMP BINDING PROTEIN; CYCLIC AMP BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; NONHUMAN; PRIORITY JOURNAL;

APOPROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC AMP RECEPTOR PROTEIN; DNA; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

ESCHERICHIA COLI;

EID: 70349734666     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908380106     Document Type: Article

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