Design of new phenothiazine-thiadiazole hybrids via molecular hybridization approach for the development of potent antitubercular agents

European Journal of Medicinal Chemistry

Volumn 106, Issue , 2015, Pages 75-84

  Ramprasad, Jurupula ^a   Nayak, Nagabhushana ^a   Dalimba, Udayakumar ^a  

^a NATIONAL INSTITUTE OF TECHNOLOGY KARNATAKA   (India)

Author keywords

1,3,4 Thiadiazole; Antimycobacterial activity; Cytotoxicity; Molecular docking; Mycobacterium tuberculosis; Phenothiazine

Indexed keywords

1 (2 CHLORO 10H PHENOTHIAZIN 10 YL) 2 [2 IMINO 5 (4 TOLYL) 1,3,4 THIADIAZOL 3(2H) YL] ETHANONE; 1 (2 CHLORO 10H PHENOTHIAZIN 10 YL) 2 [2 IMINO 5 METHYL 1, 3, 4 THIADIAZOL 3(2H)YL]ETHANONE; 1 (2 CHLORO 10H PHENOTHIAZIN 10 YL) 2 [2 IMINO 5 PROPYL 1,3,4 THIADIAZOL 3(2H) YL]ETHANONE; 1 (2 CHLORO 10H PHENOTHIAZIN 10 YL) 2 [5 (3,4 DIMETHOXYPHENYL) 2 IMINO 1,3,4-THIADIAZOL 3(2H) YL]ETHANONE; 1 (2 CHLORO 10H PHENOTHIAZIN 10 YL) 2 [5 (4 FLUOROPHENYL) 2 IMINO 1, 3, 4 THIADIAZOL 3(2H) YL]ETHANONE; 1 (2 CHLORO 10H PHENOTHIAZIN 10 YL) 2 [5(4 CHLOROPHENYL) 2 IMINO 1,3,4 THIADIAZOL 3(2H) YL] ETHANONE; 1,3,4 THIADIAZOLE DERIVATIVE; 2 (2 IMINO 5 PROPYL 1,3,4 THIADIAZOL 3(2H) YL] 1 (10H PHENOTHIAZIN 10 YL) ETHANONE; 2 (2 IMINO 5 PROPYL 1,3,4 THIADIAZOL 3(2H) YL] 1 [2 (TRIFLUOROMETHYL) 10H PHENOTHIAZIN 10 YL] ETHANONE; 2 AMINO 5 SUBSITUTED 1,3,4 THIADIAZOLE DERIVATIVE; 2 CHLORO 1 (10H PHENOTHIAZIN 10 YL)ETHANONE DERIVATIVE; 2 [2 IMINO 5 (4 TOLYL) 1,3,4 THIADIAZOL 3(2H) YL] 1 [2 (TRIFLUOROMETHYL) 10H PHENOTHIAZIN 10 YL] ETHANONE; 2 [2 IMINO 5 METHYL 1,3,4 THIADIAZOL 3(2H) YL] 1 (10H PHENOTHIAZIN 10 YL)ETHANONE; 2 [2 IMINO 5 METHYL 1,3,4 THIADIAZOL 3(2H) YL] 1 [2 (TRIFLUOROMETHYL) 10H PHENOTHIAZIN 10 YL] ETHANONE; 2 [5 (3,4 DIMETHOXYPHENYL) 2 IMINO 1,3,4-THIADIAZOL 3(2H) YL] 1 (10H PHENOTHIAZIN 10 YL) ETHANONE; 2 [5 (3,4 DIMETHOXYPHENYL) 2 IMINO 1,3,4-THIADIAZOL 3(2H) YL] 1 [2 (TRIFLUOROMETHYL) 10H PHENOTHIAZIN 10 YL]ETHANONE; 2 [5 (4 CHLOROPHENYL) 2 IMINO 1,3,4 THIADIAZOL 3(2H) YL] 1 (10H PHENOTHIAZIN 10 YL)ETHANONE; 2 [5 (4 CHLOROPHENYL) 2 IMINO 1,3,4 THIADIAZOL 3(2H) YL] 1 [2 (TRIFLUOROMETHYL) 10H PHENOTHIAZIN 10 YL]ETHANONE; 2 [5 (4 FFLUOROPHENYL) 2 IMINO 1,3,4 THIADIAZOL 3(2H) YL]1 (10H PHENOTHIAZINE 10 YL] ETHANONE; 2 [5 (4 FLUOROPHENYL) 2 IMINO 1,3,4 THIADIAZOL 3(2H) YL] 1 (10H PHENOTHIAZIN 10 YL) ETHANONE; 2 [5 (4 FLUOROPHENYL) 2 IMINO 1,3,4 THIADIAZOL 3(2H) YL] 1 [2 (TRIFLUOROMETHYL) 10H PHENOTHIAZIN 10 YL] ETHANONE; 2[(2 IMINO 5 PARA TOLYL 1,3,4 THIADIAZOL 3(2H) YL] 1 (10H PHENOTHIAZIN 10 YL) ETHANONE; CIPROFLOXACIN; ETHAMBUTOL; ISONIAZID; PHENOTHIAZINE DERIVATIVE; STREPTOMYCIN; THIADIAZOLE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; PHENOTHIAZINE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR HYBRIDIZATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VERO CELL LINE; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; DOSE RESPONSE; DRUG EFFECTS; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TEST; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; SYNTHESIS;

ANIMALS; ANTITUBERCULAR AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PHENOTHIAZINES; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; VERO CELLS;

EID: 84945972544     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.10.035     Document Type: Article

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