Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 5, 2007, Pages 1346-1348

  Bate, Aaron B ^a   Kalin, Jay H ^a   Fooksman, Eric M ^a   Amorose, Erica L ^a   Price, Cristofer M ^a   Williams, Heather M ^a   Rodig, Michael J ^a   Mitchell, Miguel O ^a   Cho, Sang Hyun ^b   Wang, Yuehong ^b   Franzblau, Scott G ^b  

^a SALISBURY UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antitubercular; Chlorpromazine; Promazine; Promethazine; Quaternized; Triflupromazine

Indexed keywords

BROMINE DERIVATIVE; PHENOTHIAZINE; PROMAZINE; PROMETHAZINE; TRIFLUPROMAZINE; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; DRUG ACTIVITY; DRUG POTENCY; ELECTRON TRANSPORT; GROWTH INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; VERO CELL;

ANTITUBERCULAR AGENTS; CHLORPROMAZINE; MYCOBACTERIUM TUBERCULOSIS; PROMAZINE; PROMETHAZINE; QUATERNARY AMMONIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIFLUPROMAZINE;

MYCOBACTERIUM TUBERCULOSIS;

EID: 33846929918     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.091     Document Type: Article

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