Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

Analytica Chimica Acta

Volumn 898, Issue , 2015, Pages 85-92

  Chen, Yongli ^a,c   Gao, Dan ^b   Liu, Hongxia ^b   Lin, Shuo ^c   Jiang, Yuyang ^a,b  

^a Tsinghua University   (China)

^b TSINGHUA UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Anticancer drug screening; Cell apoptosis; Microfluidic chip; Signaling pathway; Tumor spheroid

Indexed keywords

CELL DEATH; CELL SIGNALING; CHEMOTHERAPY; CYTOTOXICITY; FLUIDIC DEVICES; MICROFLUIDICS; PHYSIOLOGY; SIGNALING; TUMORS;

ANTICANCER DRUG; CELL APOPTOSIS; MICROFLUIDIC CHIP; SIGNALING PATHWAYS; TUMOR SPHEROID;

DIAGNOSIS;

CASPASE 3; CASPASE 7; CASPASE 8; DOXORUBICIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; ANTINEOPLASTIC AGENT;

APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RESPONSE; DRUG SCREENING; DRUG SENSITIVITY; EQUIPMENT DESIGN; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; LABORATORY DEVICE; MICROFLUIDIC ANALYSIS; MICROPLATE READER; MICROWELL BASED MICROFLUIDIC CHIP; MULTICELLULAR SPHEROID; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR SPHEROID; DRUG EFFECTS; LAB ON A CHIP; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; LAB-ON-A-CHIP DEVICES; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR;

EID: 84945945315     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2015.10.006     Document Type: Article

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