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Volumn 37, Issue 4, 2016, Pages 4831-4840

miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells

Author keywords

Apoptosis; G2 M arrest; miR 449a; pRb E2F1; Prostate cancer; Radiosensitivity

Indexed keywords

MICRORNA; MICRORNA 449A; PEPTIDES AND PROTEINS; PROTEIN CDC25A; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; E2F1 PROTEIN, HUMAN; MIRN449 MICRORNA, HUMAN;

EID: 84945563545     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-4336-8     Document Type: Article
Times cited : (36)

References (45)
  • 1
    • 84920837701 scopus 로고    scopus 로고
    • Cancer statistics, 2015
    • PID: 25559415
    • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29. doi:10.3322/caac.21254.
    • (2015) CA Cancer J Clin , vol.65 , Issue.1 , pp. 5-29
    • Siegel, R.L.1    Miller, K.D.2    Jemal, A.3
  • 2
    • 84872815960 scopus 로고    scopus 로고
    • Radiosensitization in prostate cancer: mechanisms and targets
    • PID: 23351141
    • Palacios DA, Miyake M, Rosser CJ. Radiosensitization in prostate cancer: mechanisms and targets. BMC Urol. 2013;13:4. doi:10.1186/1471-2490-13-4.
    • (2013) BMC Urol , vol.13 , pp. 4
    • Palacios, D.A.1    Miyake, M.2    Rosser, C.J.3
  • 3
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • COI: 1:CAS:528:DC%2BD1MXhs1Kiuro%3D, PID: 19167326
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215–33. doi:10.1016/j.cell.2009.01.002.
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 4
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • COI: 1:CAS:528:DC%2BD1MXptFWjuw%3D%3D, PID: 18955434
    • Friedman RC, Farh KK-H, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92–105. doi:10.1101/gr.082701.108.
    • (2009) Genome Res , vol.19 , Issue.1 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.-H.2    Burge, C.B.3    Bartel, D.P.4
  • 6
    • 84907521787 scopus 로고    scopus 로고
    • microRNA expression and biogenesis in cellular response to ionizing radiation
    • COI: 1:CAS:528:DC%2BC2cXhs1eisrvL, PID: 24905898
    • Mao A, Liu Y, Zhang H, Di C, Sun C. microRNA expression and biogenesis in cellular response to ionizing radiation. DNA Cell Biol. 2014;33(10):667–79. doi:10.1089/dna.2014.2401.
    • (2014) DNA Cell Biol , vol.33 , Issue.10 , pp. 667-679
    • Mao, A.1    Liu, Y.2    Zhang, H.3    Di, C.4    Sun, C.5
  • 7
    • 84868629172 scopus 로고    scopus 로고
    • Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity
    • COI: 1:CAS:528:DC%2BC38Xhs1Wqsb7N, PID: 22798379
    • Zhao L, Bode AM, Cao Y, Dong Z. Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity. Carcinogenesis. 2012;33(11):2220–7. doi:10.1093/carcin/bgs235.
    • (2012) Carcinogenesis , vol.33 , Issue.11 , pp. 2220-2227
    • Zhao, L.1    Bode, A.M.2    Cao, Y.3    Dong, Z.4
  • 8
    • 34548814135 scopus 로고    scopus 로고
    • MicroRNAs and cell cycle regulation
    • Carleton M, Cleary MA, Linsley PS. MicroRNAs and cell cycle regulation. Cell Cycle. 2014;6(17):2127–32. doi:10.4161/cc.6.17.4641.
    • (2014) Cell Cycle , vol.6 , Issue.17 , pp. 2127-2132
    • Carleton, M.1    Cleary, M.A.2    Linsley, P.S.3
  • 9
    • 80052399265 scopus 로고    scopus 로고
    • MicroRNA-449 in cell fate determination
    • Lizé M, Klimke A, Dobbelstein M. MicroRNA-449 in cell fate determination. Cell Cycle. 2014;10(17):2874–82. doi:10.4161/cc.10.17.17181.
    • (2014) Cell Cycle , vol.10 , Issue.17 , pp. 2874-2882
    • Lizé, M.1    Klimke, A.2    Dobbelstein, M.3
  • 10
    • 84964530800 scopus 로고    scopus 로고
    • Gallinas SC, Lizé M. MIR449A (microRNA 449a). Atlas Genet Cytogenet Oncol Haematol. 2013(3)
    • Gallinas SC, Lizé M. MIR449A (microRNA 449a). Atlas Genet Cytogenet Oncol Haematol. 2013(3). doi:10.4267/2042/48759.
  • 11
    • 84878466503 scopus 로고    scopus 로고
    • MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met
    • COI: 1:CAS:528:DC%2BC3sXpsFenu7o%3D, PID: 23734217
    • Luo W, Huang B, Li Z, Li H, Sun L, Zhang Q, et al. MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met. PLoS One. 2013;8(5), e64759. doi:10.1371/journal.pone.0064759.
    • (2013) PLoS One , vol.8 , Issue.5
    • Luo, W.1    Huang, B.2    Li, Z.3    Li, H.4    Sun, L.5    Zhang, Q.6
  • 12
    • 84893680111 scopus 로고    scopus 로고
    • Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells
    • COI: 1:CAS:528:DC%2BC3sXhvV2nsrrM, PID: 24211326
    • Ren XS, Yin MH, Zhang X, Wang Z, Feng SP, Wang GX, et al. Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells. Cancer Lett. 2014;344(2):195–203. doi:10.1016/j.canlet.2013.10.031.
    • (2014) Cancer Lett , vol.344 , Issue.2 , pp. 195-203
    • Ren, X.S.1    Yin, M.H.2    Zhang, X.3    Wang, Z.4    Feng, S.P.5    Wang, G.X.6
  • 13
    • 64949190804 scopus 로고    scopus 로고
    • miR-449a targets HDAC-1 and induces growth arrest in prostate cancer
    • COI: 1:CAS:528:DC%2BD1MXisVOrtrk%3D, PID: 19252524
    • Noonan EJ, Place RF, Pookot D, Basak S, Whitson JM, Hirata H, et al. miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene. 2009;28(14):1714–24. doi:10.1038/onc.2009.19.
    • (2009) Oncogene , vol.28 , Issue.14 , pp. 1714-1724
    • Noonan, E.J.1    Place, R.F.2    Pookot, D.3    Basak, S.4    Whitson, J.M.5    Hirata, H.6
  • 14
    • 84927931838 scopus 로고    scopus 로고
    • MicroRNA-449a inhibits proliferation and induces apoptosis by directly repressing E2F3 in gastric cancer
    • COI: 1:CAS:528:DC%2BC2MXnsVWjurw%3D, PID: 25871967
    • Li X, Li H, Zhang R, Liu J. MicroRNA-449a inhibits proliferation and induces apoptosis by directly repressing E2F3 in gastric cancer. Cell Physiol Biochem. 2015;35(5):2033–42. doi:10.1159/000374010.
    • (2015) Cell Physiol Biochem , vol.35 , Issue.5 , pp. 2033-2042
    • Li, X.1    Li, H.2    Zhang, R.3    Liu, J.4
  • 15
    • 84923368809 scopus 로고    scopus 로고
    • MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein
    • COI: 1:CAS:528:DC%2BC2cXitVShsrfO, PID: 25487955
    • Yao Y, Ma J, Xue Y, Wang P, Li Z, Hu Y, et al. MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein. Mol Oncol. 2015;9(3):640–56. doi:10.1016/j.molonc.2014.11.003.
    • (2015) Mol Oncol , vol.9 , Issue.3 , pp. 640-656
    • Yao, Y.1    Ma, J.2    Xue, Y.3    Wang, P.4    Li, Z.5    Hu, Y.6
  • 16
    • 84930521497 scopus 로고    scopus 로고
    • microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest
    • PID: 25760387
    • Zhao Z, Ma X, Sung D, Li M, Kosti A, Lin G, et al. microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. RNA Biol. 2015;12(5):538–54. doi:10.1080/15476286.2015.1023495.
    • (2015) RNA Biol , vol.12 , Issue.5 , pp. 538-554
    • Zhao, Z.1    Ma, X.2    Sung, D.3    Li, M.4    Kosti, A.5    Lin, G.6
  • 17
    • 80051752361 scopus 로고    scopus 로고
    • E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation
    • Yang G, Lu X, Wang L, Bian Y, Fu H, Wei M, et al. E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation. Cell Cycle. 2014;10(16):2703–13. doi:10.4161/cc.10.16.15928.
    • (2014) Cell Cycle , vol.10 , Issue.16 , pp. 2703-2713
    • Yang, G.1    Lu, X.2    Wang, L.3    Bian, Y.4    Fu, H.5    Wei, M.6
  • 18
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F induces quiescent cells to S phase
    • Johson DG, Schwarz JK, Cress WD, Nevins JR. Expression of transcription factor E2F induces quiescent cells to S phase. Nature. 1993;365:349–52.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 19
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • COI: 1:CAS:528:DC%2BD3sXlt1CktL0%3D, PID: 12853964
    • Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 2003;424(6945):223–8.
    • (2003) Nature , vol.424 , Issue.6945 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 20
    • 21144441497 scopus 로고    scopus 로고
    • Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy
    • COI: 1:CAS:528:DC%2BD2MXks1OhtL4%3D, PID: 15930274
    • Mayhew CN, Bosco E, Fox SR, Okaya T, Tarapore P, Schwemberger SJ, et al. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Res. 2005;65(11):4568–77.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4568-4577
    • Mayhew, C.N.1    Bosco, E.2    Fox, S.R.3    Okaya, T.4    Tarapore, P.5    Schwemberger, S.J.6
  • 21
    • 84875945038 scopus 로고    scopus 로고
    • p15(PAF) is an Rb/E2F-regulated S-phase protein essential for DNA synthesis and cell cycle progression
    • COI: 1:CAS:528:DC%2BC3sXmt1Gmur8%3D, PID: 23593430
    • Chang CN, Feng MJ, Chen YL, Yuan RH, Jeng YM. p15(PAF) is an Rb/E2F-regulated S-phase protein essential for DNA synthesis and cell cycle progression. PLoS One. 2013;8(4), e61196. doi:10.1371/journal.pone.0061196.
    • (2013) PLoS One , vol.8 , Issue.4
    • Chang, C.N.1    Feng, M.J.2    Chen, Y.L.3    Yuan, R.H.4    Jeng, Y.M.5
  • 22
    • 19444369864 scopus 로고    scopus 로고
    • p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2
    • COI: 1:CAS:528:DC%2BD2MXkslOgurw%3D, PID: 15827088
    • Jackson MW, Agarwal MK, Yang J, Bruss P, Uchiumi T, Agarwal ML, et al. p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2. J Cell Sci. 2005;118(Pt 9):1821–32. doi:10.1242/jcs.02307.
    • (2005) J Cell Sci , vol.118 , pp. 1821-1832
    • Jackson, M.W.1    Agarwal, M.K.2    Yang, J.3    Bruss, P.4    Uchiumi, T.5    Agarwal, M.L.6
  • 23
    • 33846547172 scopus 로고    scopus 로고
    • RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene
    • COI: 1:CAS:528:DC%2BD2sXos12qtg%3D%3D, PID: 16862181
    • Eguchi T, Takaki T, Itadani H, Kotani H. RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene. Oncogene. 2007;26(4):509–20. doi:10.1038/sj.onc.1209810.
    • (2007) Oncogene , vol.26 , Issue.4 , pp. 509-520
    • Eguchi, T.1    Takaki, T.2    Itadani, H.3    Kotani, H.4
  • 24
    • 0033150314 scopus 로고    scopus 로고
    • Hypophosphorylated retinoblastoma protein is associated with G2 arrest in esophageal squamous cell carcinoma
    • COI: 1:CAS:528:DyaK1MXjtFKhtrc%3D, PID: 10334897
    • Rigberg DA, Kim FS, Sebastian JL, Kazanjian KK, McFadden DW. Hypophosphorylated retinoblastoma protein is associated with G2 arrest in esophageal squamous cell carcinoma. J Surg Res. 1999;84(1):101–5. doi:10.1006/jsre.1999.5617.
    • (1999) J Surg Res , vol.84 , Issue.1 , pp. 101-105
    • Rigberg, D.A.1    Kim, F.S.2    Sebastian, J.L.3    Kazanjian, K.K.4    McFadden, D.W.5
  • 25
    • 70350111289 scopus 로고    scopus 로고
    • miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A
    • COI: 1:CAS:528:DC%2BD1MXhtlCktbvL, PID: 19833767
    • Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, et al. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 2009;23(20):2388–93. doi:10.1101/gad.1819009.
    • (2009) Genes Dev , vol.23 , Issue.20 , pp. 2388-2393
    • Yang, X.1    Feng, M.2    Jiang, X.3    Wu, Z.4    Li, Z.5    Aau, M.6
  • 26
    • 76749102887 scopus 로고    scopus 로고
    • E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis
    • COI: 1:CAS:528:DC%2BC3cXhvFCrs7w%3D, PID: 19960022
    • Lize M, Pilarski S, Dobbelstein M. E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. Cell Death Differ. 2010;17(3):452–8. doi:10.1038/cdd.2009.188.
    • (2010) Cell Death Differ , vol.17 , Issue.3 , pp. 452-458
    • Lize, M.1    Pilarski, S.2    Dobbelstein, M.3
  • 27
    • 84866485589 scopus 로고    scopus 로고
    • Dynamical behaviors of Rb-E2F pathway including negative feedback loops involving miR449
    • COI: 1:CAS:528:DC%2BC38XhsVWlsbnE, PID: 23028477
    • Yan F, Liu H, Hao J, Liu Z. Dynamical behaviors of Rb-E2F pathway including negative feedback loops involving miR449. PLoS One. 2012;7(9), e43908. doi:10.1371/journal.pone.0043908.
    • (2012) PLoS One , vol.7 , Issue.9
    • Yan, F.1    Liu, H.2    Hao, J.3    Liu, Z.4
  • 28
    • 84890116115 scopus 로고    scopus 로고
    • Dynamic analysis of the combinatorial regulation involving transcription factors and microRNAs in cell fate decisions
    • COI: 1:CAS:528:DC%2BC3sXht1als7%2FL, PID: 23845991
    • Yan F, Liu H, Liu Z. Dynamic analysis of the combinatorial regulation involving transcription factors and microRNAs in cell fate decisions. Biochim Biophys Acta. 2014;1844(1 Pt B):248–57. doi:10.1016/j.bbapap.2013.06.022.
    • (2014) Biochim Biophys Acta , vol.1844 , Issue.1 , pp. 248-257
    • Yan, F.1    Liu, H.2    Liu, Z.3
  • 29
    • 0023598614 scopus 로고
    • Computer programs for the analysis of cellular survival data
    • COI: 1:STN:280:DyaL1c%2FmvFSqtA%3D%3D, PID: 3685260
    • Albright N. Computer programs for the analysis of cellular survival data. Radiat Res. 1987;112(2):331–40.
    • (1987) Radiat Res , vol.112 , Issue.2 , pp. 331-340
    • Albright, N.1
  • 30
    • 3042661957 scopus 로고    scopus 로고
    • Role of cell cycle in mediating sensitivity to radiotherapy
    • PID: 15234026
    • Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys. 2004;59(4):928–42. doi:10.1016/j.ijrobp.2004.03.005.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , Issue.4 , pp. 928-942
    • Pawlik, T.M.1    Keyomarsi, K.2
  • 31
    • 12544252991 scopus 로고    scopus 로고
    • Cell lines used in prostate cancer research: a compendium of old and new lines--part 1
    • COI: 1:STN:280:DC%2BD2M%2FhslagtA%3D%3D, PID: 15643172
    • Sobel RE, Sadar MD. Cell lines used in prostate cancer research: a compendium of old and new lines--part 1. J Urol. 2005;173(2):342–59. doi:10.1097/01.ju.0000141580.30910.57.
    • (2005) J Urol , vol.173 , Issue.2 , pp. 342-359
    • Sobel, R.E.1    Sadar, M.D.2
  • 32
    • 0025068887 scopus 로고
    • Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene
    • COI: 1:CAS:528:DyaK3cXhsFKjt78%3D
    • Bookstein R, Shew JY, Chen PL, Scully P, Lee WH. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science (New York, NY). 1990;247(4943):712–5.
    • (1990) Science (New York, NY) , vol.247 , Issue.4943 , pp. 712-715
    • Bookstein, R.1    Shew, J.Y.2    Chen, P.L.3    Scully, P.4    Lee, W.H.5
  • 33
    • 84896715260 scopus 로고    scopus 로고
    • Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma
    • COI: 1:CAS:528:DC%2BC2cXivVejt7g%3D, PID: 24323898
    • Tan HL, Sood A, Rahimi HA, Wang W, Gupta N, Hicks J, et al. Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma. Clin Cancer Res. 2014;20(4):890–903. doi:10.1158/1078-0432.CCR-13-1982.
    • (2014) Clin Cancer Res , vol.20 , Issue.4 , pp. 890-903
    • Tan, H.L.1    Sood, A.2    Rahimi, H.A.3    Wang, W.4    Gupta, N.5    Hicks, J.6
  • 34
    • 0025940113 scopus 로고
    • Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles
    • COI: 1:STN:280:DyaK3MzjvFWlsQ%3D%3D, PID: 1873816
    • Isaacs WB, Carter BS, Ewing CM. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. Cancer Res. 1991;51(17):4716–20.
    • (1991) Cancer Res , vol.51 , Issue.17 , pp. 4716-4720
    • Isaacs, W.B.1    Carter, B.S.2    Ewing, C.M.3
  • 35
    • 0037567586 scopus 로고    scopus 로고
    • Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells
    • COI: 1:CAS:528:DC%2BD3sXkt1aitro%3D, PID: 12782597
    • Gurova KV, Rokhlin OW, Budanov AV, Burdelya LG, Chumakov PM, Cohen MB, et al. Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells. Cancer Res. 2003;63(11):2905–12.
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2905-2912
    • Gurova, K.V.1    Rokhlin, O.W.2    Budanov, A.V.3    Burdelya, L.G.4    Chumakov, P.M.5    Cohen, M.B.6
  • 37
    • 84923068196 scopus 로고    scopus 로고
    • MiR-449a functions as a tumor suppressor in endometrial cancer by targeting CDC25A
    • COI: 1:CAS:528:DC%2BC2cXhsFOrsL%2FP, PID: 24993091
    • Ye W, Xue J, Zhang Q, Li F, Zhang W, Chen H, et al. MiR-449a functions as a tumor suppressor in endometrial cancer by targeting CDC25A. Oncol Rep. 2014;32(3):1193–9. doi:10.3892/or.2014.3303.
    • (2014) Oncol Rep , vol.32 , Issue.3 , pp. 1193-1199
    • Ye, W.1    Xue, J.2    Zhang, Q.3    Li, F.4    Zhang, W.5    Chen, H.6
  • 38
    • 84896724947 scopus 로고    scopus 로고
    • miR-449a regulates proliferation and chemosensitivity to cisplatin by targeting cyclin D1 and BCL2 in SGC7901 cells
    • COI: 1:CAS:528:DC%2BC3sXhvVaksrjO, PID: 24248414
    • Hu J, Fang Y, Cao Y, Qin R, Chen Q. miR-449a regulates proliferation and chemosensitivity to cisplatin by targeting cyclin D1 and BCL2 in SGC7901 cells. Dig Dis Sci. 2014;59(2):336–45. doi:10.1007/s10620-013-2923-3.
    • (2014) Dig Dis Sci , vol.59 , Issue.2 , pp. 336-345
    • Hu, J.1    Fang, Y.2    Cao, Y.3    Qin, R.4    Chen, Q.5
  • 39
    • 84870809468 scopus 로고    scopus 로고
    • miR-449a regulates the chondrogenesis of human mesenchymal stem cells through direct targeting of lymphoid enhancer-binding factor-1
    • COI: 1:CAS:528:DC%2BC38Xhsl2mu7jE, PID: 22769578
    • Paik S, Jung HS, Lee S, Yoon DS, Park MS, Lee JW. miR-449a regulates the chondrogenesis of human mesenchymal stem cells through direct targeting of lymphoid enhancer-binding factor-1. Stem Cells Dev. 2012;21(18):3298–308. doi:10.1089/scd.2011.0732.
    • (2012) Stem Cells Dev , vol.21 , Issue.18 , pp. 3298-3308
    • Paik, S.1    Jung, H.S.2    Lee, S.3    Yoon, D.S.4    Park, M.S.5    Lee, J.W.6
  • 40
    • 79954507936 scopus 로고    scopus 로고
    • miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells
    • PID: 20948989
    • Noonan EJ, Place RF, Basak S, Pookot D, Li LC. miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget. 2010;1(5):349–58.
    • (2010) Oncotarget , vol.1 , Issue.5 , pp. 349-358
    • Noonan, E.J.1    Place, R.F.2    Basak, S.3    Pookot, D.4    Li, L.C.5
  • 41
    • 84876249943 scopus 로고    scopus 로고
    • MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells
    • COI: 1:CAS:528:DC%2BC3sXmvVCkurk%3D, PID: 23614048
    • Liu YJ, Lin YF, Chen YF, Luo EC, Sher YP, Tsai MH, et al. MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells. PLoS One. 2013;8(4), e62383. doi:10.1371/journal.pone.0062383.
    • (2013) PLoS One , vol.8 , Issue.4
    • Liu, Y.J.1    Lin, Y.F.2    Chen, Y.F.3    Luo, E.C.4    Sher, Y.P.5    Tsai, M.H.6
  • 42
    • 0033110171 scopus 로고    scopus 로고
    • Cell cycle regulation after exposure to ionizing radiation
    • COI: 1:STN:280:DyaK1M3nsVOjtQ%3D%3D, PID: 10341340
    • Teyssier F, Bay JO, Dionet C, Verrelle P. Cell cycle regulation after exposure to ionizing radiation. Bull Cancer. 1999;86(4):345–57.
    • (1999) Bull Cancer , vol.86 , Issue.4 , pp. 345-357
    • Teyssier, F.1    Bay, J.O.2    Dionet, C.3    Verrelle, P.4
  • 43
    • 78651277873 scopus 로고    scopus 로고
    • Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis
    • COI: 1:CAS:528:DC%2BC3MXkt1eqsA%3D%3D, PID: 20933570
    • Kim SY, Yang ES, Lee YS, Lee J, Park JW. Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis. Biochimie. 2011;93(2):269–76. doi:10.1016/j.biochi.2010.09.020.
    • (2011) Biochimie , vol.93 , Issue.2 , pp. 269-276
    • Kim, S.Y.1    Yang, E.S.2    Lee, Y.S.3    Lee, J.4    Park, J.W.5
  • 44
    • 84872815960 scopus 로고    scopus 로고
    • Palacions MMaCJR. Radiosensitization in prostate cancer mechanisms and targets
    • Diego A. Palacions MMaCJR. Radiosensitization in prostate cancer mechanisms and targets. BMC Urol. 2013;13(4):1472490. doi:10.1186/1471-2490-13-4.
    • (2013) BMC Urol , vol.13 , Issue.4 , pp. 1472490
    • Diego, A.1
  • 45
    • 0032146778 scopus 로고    scopus 로고
    • Radiation-induced apoptosis mediated by retinoblastoma protein
    • COI: 1:CAS:528:DyaK1cXltFyju70%3D, PID: 9699655
    • Bowen C, Spiegel S, Gelmann EP. Radiation-induced apoptosis mediated by retinoblastoma protein. Cancer Res. 1998;58(15):3275–81.
    • (1998) Cancer Res , vol.58 , Issue.15 , pp. 3275-3281
    • Bowen, C.1    Spiegel, S.2    Gelmann, E.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.