The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways

Journal of Applied Toxicology

Volumn 35, Issue 12, 2015, Pages 1550-1556

  Takumi, Shota ^a,b   Okamura, Kazuyuki ^a   Yanagisawa, Hiroyuki ^b   Sano, Tomoharu ^a   Kobayashi, Yayoi ^a   Nohara, Keiko ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 methylcytosine (5meC); Active DNA demethylation; Hepatic DNA methylation; Methyl deficient diet; Tet family proteins; Thymine DNA glycosylase (Tdg)

Indexed keywords

5 METHYLCYTOSINE; 8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; APE1 PROTEIN; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; APURINIC ACID; APURINIC APYRIMIDINIC ENDONUCLEASE 1; DNA; DNA GLYCOSYLASE MUTY; DNA GLYCOSYLASE MUTY 1; DNA GLYCOSYLTRANSFERASE; DNA GLYCOSYLTRANSFERASE 1; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; HEME OXYGENASE 1; MESSENGER RNA; PROTEIN; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SINGLE STRANDED SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE 1; TET METHYLCYTOSINE DIOXYGENASE 2; TET METHYLCYTOSINE DIOXYGENASE 3; THYMINE DNA GLYCOSYLASE; UNCLASSIFIED DRUG; 5-HYDROXYMETHYLCYTOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; CYTOSINE; DEOXYGUANOSINE; METHIONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SHAPE; CONTROLLED STUDY; DEMETHYLATION; DIET; DIET INDUCED HEPATIC STEATOSIS; DNA DAMAGE; DNA EXTRACTION; DNA METHYLATION; DOWN REGULATION; ENZYME INHIBITION; EXCISION REPAIR; FATTY LIVER; GENE FREQUENCY; LIVER WEIGHT; MALE; METHIONINE CHOLINE DEFICIENT DIET; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE LEVEL; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; COMPLICATION; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; VITAMIN DEFICIENCY;

5-METHYLCYTOSINE; ANIMALS; CHOLINE DEFICIENCY; CYTOSINE; DEOXYGUANOSINE; DNA METHYLATION; FATTY LIVER; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; METHIONINE; MICE, INBRED C57BL; OXIDATIVE STRESS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE;

EID: 84945483017     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3117     Document Type: Article

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