PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner

Cellular and Molecular Life Sciences

Volumn 72, Issue 22, 2015, Pages 4399-4407

  Lindblad, Oscar ^a   Kazi, Julhash U ^a   Rönnstrand, Lars ^a   Sun, Jianmin ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Ba F3; Cancer; GDC0941; LY294002; Receptor tyrosine kinase; Signaling

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; STEM CELL FACTOR; 2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 2-(1H-INDAZOL-4-YL)-6-(4-METHANESULFONYLPIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YLTHIENO(3,2-D)PYRIMIDINE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MORPHOLINE DERIVATIVE; STEM CELL FACTOR RECEPTOR; SULFONAMIDE;

ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXON; GENE MUTATION; HUMAN; IN VITRO STUDY; MOLECULAR GENETICS; NONHUMAN; ONCOGENE C KIT; POINT MUTATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL TRANSFORMATION; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CHROMONES; HEK293 CELLS; HUMANS; INDAZOLES; INDOLES; MORPHOLINES; MUTATION, MISSENSE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STEM CELL FACTOR; SULFONAMIDES;

EID: 84945480952     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1944-9     Document Type: Article

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