UVB activates hypothalamic-pituitary-adrenal axis in C57BL/6 mice

Journal of Investigative Dermatology

Volumn 135, Issue 6, 2015, Pages 1638-1648

  Skobowiat, Cezary ^a   Slominski, Andrzej T ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ENDORPHIN; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; MELANOCORTIN 2 RECEPTOR; MESSENGER RNA; STEROID 11BETA MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UROCORTIN;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HOMEOSTASIS; HYPOPHYSECTOMY; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHAM PROCEDURE; STIMULATION; ULTRAVIOLET B RADIATION; ANIMAL; BRAIN; C57BL MOUSE; GENE EXPRESSION REGULATION; HYPOPHYSIS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; RADIATION RESPONSE; SKIN; ULTRAVIOLET RADIATION;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; BETA-ENDORPHIN; BRAIN; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; FEMALE; GENE EXPRESSION REGULATION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MICE; MICE, INBRED C57BL; PITUITARY GLAND; PITUITARY-ADRENAL SYSTEM; RNA, MESSENGER; SKIN; STEROID 11-BETA-HYDROXYLASE; ULTRAVIOLET RAYS; UROCORTINS;

EID: 84945456752     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.450     Document Type: Article

References (65)

1. Becklund BR, Severson KS, Vang SV et al. (2010) UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. Proc Natl Acad Sci USA 107:6418-23
2. Campbell C, Quinn AG, Angus B et al. (1993) Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation. Cancer Res 53:2697-9
3. Chakraborty AK, Funasaka Y, Slominski A et al. (1999) UV light and MSH receptors. Ann NY Acad Sci 885:100-16
4. Chrousos GP (2009) Stress and disorders of the stress system. Nat Rev Endocrinol 5:374-81
5. Cirillo N, Prime SS (2011) Keratinocytes synthesize and activate cortisol. J Cell Biochem 112:1499-505
6. Cohen S, Janicki-Deverts D, Doyle WJ et al. (2012) Chronic stress, glucocorti-coid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA 109:5995-9
7. Fell GL, Robinson KC, Mao J et al. (2014) Skin beta-endorphin mediates addiction to UV light. Cell 157:1527-34
8. Fritsche E, Schafer C, Calles C et al. (2007) Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci USA 104:8851-6
9. Hiramoto K, Yamate Y, Kobayashi H et al. (2013) Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone. Clin Exp Dermatol 38:71-6
10. Hiramoto K, Yamate Y, Sugiyama D et al. (2014) Tranexamic acid suppresses ultraviolet B eye irradiation-induced melanocyte activation by decreasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone. Photodermatol Photoimmunol Photomed 30:302-7
11. Hiramoto K, Yanagihara N, Sato EF et al. (2003) Ultraviolet B irradiation of the eye activates a nitric oxide-dependent hypothalamopituitary proopiome-lanocortin pathway and modulates functions of alpha-melanocyte-stimulating hormone-responsive cells. J Invest Dermatol 120:123-7
12. Holick MF (2003) Vitamin D: a millenium perspective. J Cell Biochem 88: 296-307
13. International Commission on Illumination (CIE) (1999) International Standard ISO 17166:1999(E)-CIE 007/E:1998, Erythema Reference Action Spectrum and Standard Erythema Dose. 1st edn. International Organization for Standardization (ISO): Geneva, Switzerland
14. Ito N, Ito T, Kromminga A et al. (2005) Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J 19:1332-4
15. Juzeniene A, Moan J (2012) Beneficial effects of UV radiation other than via vitamin D production. Dermatoendocrinology 4:109-17
16. Kirnbauer R, Kock A, Neuner P et al. (1991) Regulation of epidermal cell interleukin-6 production by UV light and corticosteroids. J Invest Dermatol 96:484-9
17. Kourosh AS, Harrington CR, Adinoff B (2010) Tanning as a behavioral addiction. Am J Drug Alcohol Abuse 36:284-90
18. Kripke ML (1994) Ultraviolet radiation and immunology: something new under the sun-presidential address. Cancer Res 54:6102-5
19. Krutmann J, Morita A, Chung JH (2012) Sun exposure: what molecular photodermatology tells us about its good and bad sides. J Invest Dermatol 132:976-84
20. McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87:873-904
21. Miller WL, Auchus RJ (2011) The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev 32:81-151
22. Muthusamy V, Piva TJ (2010) The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathways. Arch Dermatol Res 302:5-17
23. Ndiaye MA, Nihal M, Wood GS et al. (2013) Skin, reactive oxygen species, and circadian clocks. Antioxid Redox Signal 20:2982-96
24. Nolan BV, Taylor SL, Liguori A et al. (2009) Tanning as an addictive behavior: a literature review. Photodermatol Photoimmunol Photomed 25:12-9
25. O'Kane M, Murphy EP, Kirby B (2006) The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease. Exp Dermatol 15:143-53
26. Paus R, Theoharides TC, Arck PC (2006) Neuroimmunoendocrine circuitry of the 'brain-skin connection. Trends Immunol 27:32-9
27. Pawelek JM, Chakraborty AK, Osber MP et al. (1992) Molecular cascades in UV-induced melanogenesis: a central role for melanotropins? Pigment Cell Res 5:348-56
28. Roloff B, Fechner K, Slominski A et al. (1998) Hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin. FASEB J 12:287-97
29. Schauer E, Trautinger F, Kock A et al. (1994) Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes. J Clin Invest 93:2258-62
30. Schiller M, Brzoska T, Bohm M et al. (2004) Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopio-melanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo. J Invest Dermatol 122:468-76
31. Schwarz A, Navid F, Sparwasser T et al. (2011) In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity. J Allergy Clin Immunol 128:826-33
32. Schwarz A, Navid F, Sparwasser T et al. (2012) 1, 25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression. J Invest Dermatol 132:2762-9
33. Schwarz T, Luger TA (1989) Effect of UV irradiation on epidermal cell cytokine production. J Photochem Photobiol B 4:1-13
34. Selye H (1976) The Stress of Life. Revised edn. McGraw-Hill Book Company: New York, NY, p 515
35. Skobowiat C, Dowdy JC, Sayre RM et al. (2011) Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab 301:E484-93
36. Skobowiat C, Nejati R, Lu L et al. (2013a) Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses. Gene 530:1-7
37. Skobowiat C, Sayre RM, Dowdy JC et al. (2013b) Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo. Br J Dermatol 168:595-601
38. Slominski A, Baker J, Ermak G et al. (1996a) Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes. FEBS Lett 399:175-6
39. Slominski A, Botchkareva NV, Botchkarev VA et al. (1998) Hair cycle-dependent production of ACTH in mouse skin. Biochim Biophys Acta 1448:147-52
40. Slominski A, Ermak G, Hwang J et al. (1996b) The expression of proopiome-lanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin. Biochim Biophys Acta 1289:247-51
41. Slominski A, Gomez-Sanchez CE, Foecking MF et al. (2000a) Active steroido-genesis in the normal rat skin. Biochim Biophys Acta 1474:1-4
42. Slominski A, Paus R (1993) Melanogenesis is coupled to murine anagen: toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol 101:90 S-97
43. Slominski A, Paus R, Mazurkiewicz J (1992) Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia 48:50-4
44. Slominski A, Pawelek J (1998) Animals under the sun: effects of ultraviolet radiation on mammalian skin. Clin Dermatol 16:503-15
45. Slominski A, Pisarchik A, Tobin DJ et al. (2004) Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 145:941-50
46. Slominski A, Roloff B, Curry J et al. (2000b) The skin produces urocortin. J Clin Endocrinol Metab 85:815-23
47. Slominski A, Wortsman J (2000) Neuroendocrinology of the skin. Endocr Rev 21:457-87
48. Slominski A, Wortsman J, Luger T et al. (2000c) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80:979-1020
49. Slominski A, Wortsman J, Pisarchik A et al. (2001) Cutaneous expression of corticotropin releasing hormone (CRH), urocortin, and CRH receptors. FASEB J 15:1678-93
50. Slominski A, Wortsman J, Tuckey RC et al. (2007) Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol 265-266:143-9
51. Slominski A, Zbytek B, Nikolakis G et al. (2013a) Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol 137:107-23
52. Slominski A, Zbytek B, Semak I et al. (2005a) CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol 162:97-102
53. Slominski A, Zbytek B, Szczesniewski A et al. (2005b) CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab 288:E701-6
54. Slominski A, Zbytek B, Szczesniewski A et al. (2006a) Cultured human dermal fibroblasts do produce cortisol. J Invest Dermatol 126:1177-8
55. Slominski A, Zbytek B, Zmijewski M et al. (2006b) Corticotropin releasing hormone and the skin. Front Biosci 11:2230-48
56. Slominski AT, Botchkarev V, Choudhry M et al. (1999) Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?" Ann NY Acad Sci 885:287-311
57. Slominski AT, Manna PR, Tuckey RC (2014) Cutaneous glucocorticosteroido-genesis: securing local homeostasis and the skin integrity. Exp Dermatol 23:369-74
58. Slominski AT, Zmijewski MA, Skobowiat C et al. (2012) Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol 212, v, vii1-115
59. Slominski AT, Zmijewski MA, Zbytek B et al. (2013b) Key role of CRF in the skin stress response system. Endocr Rev 34:827-84
60. Smith SM, Vale WW (2006) The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialog Clin Neurosci 8:383-95
61. Turnbull AV, Rivier CL (1999) Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 79:1-71
62. Vale W, Spiess J, Rivier C et al. (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213:1394-7
63. Vink AA, Moodycliffe AM, Shreedhar V et al. (1997) The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers. Proc Natl Acad Sci USA 94:5255-60
64. Vukelic S, Stojadinovic O, Pastar I et al. (2011) Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem 286:10265-75
65. Zbytek B, Wortsman J, Slominski A (2006) Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol 20:2539-47