Keratinocytes synthesize and activate cortisol

Journal of Cellular Biochemistry

Volumn 112, Issue 6, 2011, Pages 1499-1505

  Cirillo, Nicola ^a   Prime, Stephen S ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

11 HSD; cortisol; glycyrrhetinic acid; keratinocytes; skin

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; CORTICOTROPIN RECEPTOR; CORTISONE; CYTOCHROME P450; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDERMIS CELL; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEROIDOGENESIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROCORTISONE; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, SMALL INTERFERING;

EID: 79954507291     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23081     Document Type: Article

References (34)

1. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE,. 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106: 761-771. (Pubitemid 18089976)
2. Bujalska IJ, Kumar S, Stewart PM,. 1997. Does central obesity reflect "Cushing's disease of the omentum "? Lancet 349: 1210-1213. (Pubitemid 27190044)
3. Bujalska IJ, Kumar S, Hewison M, Stewart PM,. 1999. Differentiation of adipose stromal cells: The roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase. Endocrinology 140: 3188-3196. (Pubitemid 30650636)
4. Bush IE,. 1969. 11β-Hydroxysteroid dehydrogenase: Contrast between studies in vivo and studies in vitro. Adv Biosci 3: 23-39.
5. Cirillo N, Femiano F, Gombos F, Lanza A,. 2006. Serum from pemphigus vulgaris reduces desmoglein 3 half-life and perturbs its de novo assembly to desmosomal sites in cultured keratinocytes. FEBS Lett 580: 3276-3281. (Pubitemid 43729682)
6. Cirillo N, Prime SS,. 2009. Desmosomal interactome in keratinocytes: A systems biology approach leading to an understanding of the pathogenesis of skin disease. Cell Mol Life Sci 66: 3517-3533.
7. Fusenig NE, Boukamp P,. 1998. Multiple stages and genetic alterations in immortalization, malignant transformation, and tumour progression of human skin keratinocytes. Mol Carcinog 23: 144-158. (Pubitemid 28535818)
8. Gronau S, Koenig GD, Jerg M, Riechelmann H,. 2002. 11β- Hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck. Clin Otolaryngol 27: 453-457. (Pubitemid 36042866)
9. Hammami MM, Siiteri PK,. 1991. Regulation of 11β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: Enzymatic modulation of glucocorticoid action. J Clin Endocrinol Metab 73: 326-334. (Pubitemid 21921877)
10. Hannen RF, Michael AE, Jaulim A, Bhogal R, Burrin JM, Philpott MP,. 2011. Steroid synthesis by primary human keratinocytes; implications for skin disease. Biochem Biophys Res Commun 404: 62-67.
11. Hardy R, Rabbitt EH, Filer A, Emery P, Hewison M, Stewart PM, Gittoes NJ, Buckley CD, Raza K, Cooper MS,. 2008. Local and systemic glucocorticoid metabolism in inflammatory arthritis. Ann Rheum Dis 67: 1204-1210.
12. Hardy RS, Filer A, Cooper MS, Parsonage G, Raza K, Hardie DL, Rabbitt EH, Stewart PM, Buckley CD, Hewison M,. 2006. Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: A mechanism for tissue-specific regulation of inflammation. Arthritis Res Ther 8: R108.
13. Hennebold JD, Daynes RA,. 1998. Inhibition of skin 11beta-hydroxysteroid dehydrogenase activity in vivo potentiates the anti-inflammatory actions of glucocorticoids. Arch Dermatol Res 290: 413-419. (Pubitemid 28431849)
14. Hengge UR, Ruzicka T, Schwartz RA, Cork MJ,. 2006. Adverse effects of topical glucocorticosteroids. J Am Acad Dermatol 54: 1-15.
15. Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, Kees F, Straub RH, Paus R,. 2005. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J 19: 1332-1334. (Pubitemid 41113740)
16. Jackson S, Gilchrist H, Nesbitt LT, Jr., 2007. Update on the dermatologic use of systemic glucocorticosteroids. Dermatol Ther 20: 187-205. (Pubitemid 350029309)
17. Jenkins JS,. 1966. The metabolism of cortisol by human extrahepatic tissues. J Endocrinol 34: 51-56.
18. John S, Johnson TA, Sung MH, Biddie SC, Trump S, Koch-Paiz CA, Davis SR, Walker R, Meltzer PS, Hager GL,. 2009. Kinetic complexity of the global response to glucocorticoid receptor action. Endocrinology 150: 1766-1774.
19. Lanza A, Cirillo N, Rossiello R, Rienzo M, Cutillo L, Casamassimi A, de Nigris F, Schiano C, Rossiello L, Femiano F, Gombos F, Napoli C,. 2008. Evidence of key role of Cdk2 overexpression in pemphigus vulgaris. J Biol Chem 283: 8736-8745.
20. Napoli C, de Nigris F, Sica V,. 2005. New advances in microarrays: Finding the genes causally involved in disease. Methods Mol Med 108: 215-233.
21. Nguyen VT, Arredondo J, Chernyavsky AI, Kitajima Y, Pittelkow M, Grando SA,. 2004. Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes. J Biol Chem 279: 2135-2146. (Pubitemid 38084487)
22. Odermatt A, Nashev LG,. 2010. The glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations. J Steroid Biochem Mol Biol 119: 1-13.
23. Osinski PA,. 1960. Steroid 11β-ol dehydrogenase in human placenta. Nature 187: 777.
24. Prime SS, Nixon SV, Crane IJ, Stone A, Matthews JB, Maitland NJ, Remnant L, Powell SK, Game SM, Scully C,. 1990. The behaviour of human oral squamous cell carcinoma in cell culture. J Pathol 160: 259-269. (Pubitemid 20115509)
25. Raza K, Hardy R, Cooper MS,. 2010. The 11{beta}-hydroxysteroid dehydrogenase enzymes-Arbiters of the effects of glucocorticoids in synovium and bone. Rheumatology (Oxford) 49: 2016-2023. DOI: 10.1093/rheumatology/keq212.
26. Stahn C, Buttgereit F,. 2008. Genomic and nongenomic effects of glucocorticoids. Nat Clin Pract Rheumatol 4: 525-533.
27. Slominski A, Ermak G, Hwang J, Chakraborty A, Mazurkiewicz JE, Mihm M,. 1995. Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin. FEBS Lett 374: 113-116.
28. Slominski A, Zbytek B, Szczesniewski A, Semak I, Kaminski J, Sweatman T, Wortsman J,. 2004. CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab 288: E701-6. (Pubitemid 40397204)
29. Slominski A, Wortsman J, Tuckey RC, Paus R,. 2007. Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol 265-266:143-149.
30. Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR,. 1990. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 335: l060-1063.
31. Tomlinson JW, Walker EA, Bujalska IJ, Drapper N, Lavery GG, Cooper MS, Hewison M, Stewart PM,. 2004. 11β-Hydroxysteroid dehydrogenase type 1: A tissue-specific regulator of glucocorticoid response. Endocr Rev 25: 831-866. (Pubitemid 39366049)
32. Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M,. 2011. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem. DOI: 10.1074/jbc.M110.188268.
33. Viau V,. 2002. Functional cross-talk between the hypothalamic-pituitary- gonadal and -adrenal axes. J Neuroendocrinol 14: 506-513. (Pubitemid 34537739)
34. Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC,. 2009. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest 119: 876-885.