Tranexamic acid suppresses ultraviolet B eye irradiation-induced melanocyte activation by decreasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone

Photodermatology Photoimmunology and Photomedicine

Volumn 30, Issue 6, 2014, Pages 302-307

  Hiramoto, Keiichi ^a,b   Yamate, Yurika ^b   Sugiyama, Daijiro ^c   Takahashi, Yumi ^c   Mafune, Eiichi ^c  

^a SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Dopa positive melanocyte; Prohormone convertase 2; Tranexamic acid; Ultraviolet B; melanocyte stimulating hormone

Indexed keywords

AGOUTI PROTEIN; ALPHA INTERMEDIN; AMINO ACID; BETA ENDORPHIN; CORTICOTROPIN; CYSTEINE; FIBROBLAST GROWTH FACTOR 2; MELANOCORTIN RECEPTOR AGONIST; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 2; SUBTILISIN; TRANEXAMIC ACID;

ADENOHYPOPHYSIS; ALUMINUM FOIL; ANIMAL EXPERIMENT; ARTICLE; BODY SURFACE; CELL ACTIVATION; CONTROLLED STUDY; HYPOPHYSECTOMY; HYPOPHYSIS; IRRADIATION; MALE; MELANOCYTE; MOUSE; NONHUMAN; ULTRAVIOLET B RADIATION; WATER TREATMENT; ANIMAL; BLOOD; CYTOLOGY; DBA MOUSE; ENZYMOLOGY; EYE; METABOLISM; RADIATION RESPONSE; SURGERY; ULTRAVIOLET RADIATION;

ALPHA-MSH; ANIMALS; EYE; MALE; MELANOCYTES; MICE; MICE, INBRED DBA; PITUITARY GLAND; PROPROTEIN CONVERTASE 2; TRANEXAMIC ACID; ULTRAVIOLET RAYS;

EID: 84911986281     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/phpp.12131     Document Type: Article

References (19)

1. Abiko Y, Iwamoto M. Plasminogen-Plasmin system. VII. Potentiation of antifibrinolytic action of a synthetic inhibitor, tranexamic acid, by alpha 2-macroglobulin antiplasmin. Biochim Biophys Acta 1970; 214: 411-418.
2. Chang WC, Shi GY, Chow YH etal. Human plasma induces a receptor-mediated arachidonate release coupled with G protein in endothelial cells. Am J Physiol 1993; 264: 271-281.
3. Weide I, Tippler B, Syrovets T, Simmet T. Plasma is a specific stimulus of the 5-lipoxygenase pathway of human peripheral monocytes. Thromb Heamost 1996; 76: 561-568.
4. Liao LL, Pang GY. Effect observation of acidum tranexamicum on treating chloasma. Chin J Dermatovenereol 2006; 20: 675-676.
5. Li D, Shi Y, Li M, Liu J, Feng X. Tranexamic acid can treat ultraviolet radiation-induced pigmentation in guinea pigs. Eur J Dermatol 2010; 20: 289-292.
6. Wang N, Zhang L, Miles L, Hoover-Plow J. Plasminogen regulates pro-opiomelanocortin processing. J Thromb Haemost 2004; 2: 785-796.
7. Falcone DJ, McCaffrey TA, Haimovitz-Friedman A, Vergilio JA, Nicholson AC. Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation. J Biol Chem 1993; 268: 11951-11958.
8. Zhang XY, Yang XH etal. Study of inhibitory effect of acidum tranexamicum on melanin synthesis. Chin J Dermatovenerol Integr Tradi West Med 2003; 2: 227-229.
9. Hiramoto K, Yanagihara N, Sato EF, Inoue M. Ultraviolet B irradiation of the eye activates a nitric oxide-dependent hypothalamopituitary proopiomelanocortin pathway and modulates functions of α-Melanocyte-Stimulating hormone-responsive cells. J Invest Dermatol 2003; 120: 123-127.
10. Jimbow K, Uesugi T. New melanogenesis and photobiological processes in activation and proliferation of precursor melanocytes after UV-exposure: ultrastructural differentiation of precursor melanocytes from Langerhans cells. J Invest Dermatol 1982; 78: 108-115.
11. Catania A, Lipton JM. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 1993; 14: 564-576.
12. Takahashi A, Yasuda S, Mizuno N. Determination of the action spectrum for UV-induced plasminogen activator synthesis in mouse keratinocytes in vitro. J Dermatol Sci 1992; 4: 11-17.
13. Nakano T, Fujita H, Kikuchi N, Arita H. Plasmin converts pro-form of group 1 phospholipase A2 into receptor binding, active forms. Biochem Biophys Res Commun 1994; 198: 10-15.
14. Naldini L, Tamagnone L, Vigna E etal. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 1992; 11: 4825-4833.
15. Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH. alpha-MSH, and beta-endorphin. Endocr 2009; 35: 429-437.
16. Castro MG, Morrison E. Post-translational processing of proopiomelanocortin in the pituitary and in the Brain. Crit Rev Neurobiol 1997; 11: 35-57.
17. Smith AI, Funder JW. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev 1988; 9: 159-179.
18. Corner J, Chun J, Harter D, Axel R. Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1. Proc Natl Acad Sci USA 1991; 88: 6834-6838.
19. Thomas L, Leduc R, Thorne BA, Smeekens SP, Steiner DF, Thomas G. Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Proc Natl Acad Sci USA 1991; 88: 5297-5301.