IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22phox and NOX4 activity in human articular chondrocytes

Osteoarthritis and Cartilage

Volumn 23, Issue 11, 2015, Pages 1972-1980

  Rousset, F ^a   Hazane Puch, F ^b   Pinosa, C ^a   Nguyen, M V C ^a   Grange, L ^b   Soldini, A ^b   Rubens Duval, B ^b   Dupuy, C ^c   Morel, F ^a   Lardy, B ^a,b  

^a UNIV GRENOBLE ALPES   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Chondrocytes; IL1b; MMPs; NADPH oxidase 4; Osteoarthritis; ROS

Indexed keywords

AGGRECANASE 1; COLLAGENASE 3; HEME OXYGENASE 1; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; PROTEIN P22PHOX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG; 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLINE-5-ONE; DNA; HAPTEN; NOX4 PROTEIN, HUMAN; OXAZOLE DERIVATIVE;

ADULT; AGED; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HIP OSTEOARTHRITIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; BIOSYNTHESIS; CELL CULTURE; CONFOCAL MICROSCOPY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SECRETION (PROCESS); TRANSCRIPTION INITIATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DNA; FEMALE; GENE EXPRESSION REGULATION; HAPTENS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; MALE; MATRIX METALLOPROTEINASES, SECRETED; MICROSCOPY, CONFOCAL; MIDDLE AGED; NADPH OXIDASE; OSTEOARTHRITIS, HIP; OXAZOLES; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84945313535     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.02.167     Document Type: Article

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